Results 181 to 190 of about 7,339,385 (306)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Diagnosis of Tuberculous Meningitis: Integrating Clinical Assessment and Molecular Diagnostics. [PDF]

Diagnostics (Basel)
Leiva-Ordoñez JE, Quintero B.
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Validation of Dried Saliva for Molecular Diagnostics. [PDF]

ACS Meas Sci Au
Mora AC, Sogn AK, Tierney AJ, Tzavaras E, Singh ML, Mahn Arteaga G, Omenetto FG, Papas A, Mace CR.   +8 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Fibroblast Transcriptomics in Molecular Diagnostics of a Comprehensive Dystonia Cohort. [PDF]

Ann Neurol
Saparov A, Dzinovic I, Brunet T, Yépez VA, Hölzlwimmer F, Indelicato E, Assmann B, Badmann S, Ballhausen D, Berweck S, Brechtmann F, Brugger M, Derderian K, Distelmaier F, Harrer P, Harvanova D, Havrankova P, Jaroszynski AK, Kolnikova M, Kopajtich R, Koy A, Krygier M, Kunc L, Kusikova K, Maier O, Mazurkiewicz-Bełdzińska M, Mertes C, Oberlack A, Roser T, Sitzberger A, Sorrentino U, Stehr AM, Vill K, Wagner M, Prokisch H, Boesch S, Necpal J, Jech R, Winkelmann J, Graf E, Gagneur J, Skorvanek M, Zech M.   +42 more
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Stewardship of Molecular Diagnostics in Transplant Viral Infections. [PDF]

Transpl Infect Dis
Sugden S, Reynoso D, Mathew R, Loeffelholz M.   +3 more
europepmc   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

Beyond the Globe: Molecular Diagnostics of Optic Nerve, Orbital, and Adnexal Neoplasms. [PDF]

Transl Vis Sci Technol
Dankberg A, Yu G, Rodriguez FJ.
europepmc   +1 more source