Results 91 to 100 of about 410,977 (285)

Cytotoxic Evaluation, Molecular Docking, and 2D-QSAR Studies of Dihydropyrimidinone Derivatives as Potential Anticancer Agents [PDF]

, 2022
Reem Altaf, Humaira Nadeem, Umair Ilyas, Jamshed Iqbal, Rehan Zafar Paracha, Hajra Zafar, Ana Cláudia Paiva‐Santos, Muhammad Sulaiman, Faisal Raza   +8 more
openalex   +1 more source

Host‐Guest Inclusion Chemistry From Supramolecular Architecture Enabling Anti‐Biofouling Surfaces for Oesophagus Stents

Advanced Functional Materials, EarlyView.
A slippery coating with exceptional anti‐biofouling performance is developed using biocompatible materials for oesophagus stents. Host‐guest inclusion complex formation capabilities of FDA‐approved supramolecules, cyclodextrins are exploited, which significantly enhances the stability of the surface.
Jianhui Zhang, Haowei Wang, Sourabh Dogra, Xiaoye Zhao, Wenqing Chen, Arpan Gupta, Manish K. Tiwari, Vikramjeet Singh   +7 more
wiley   +1 more source

In Silico Approaches for Rational Drug Design and Potential Enzyme Inhibitors Discovery: A Mini-Review [PDF]

Journal of Advanced Biomedical Sciences
The field of drug design has undergone remarkable advancements with the advent of in silico methods, which utilize computational approaches that accelerate the discovery and development of novel therapeutics.
Morteza Sadeghi, Mehran Miroliaei, Mustafa Ghanadian   +2 more
doaj  

Uses of Molecular Docking Simulations in Elucidating Synergistic, Additive, and/or Multi-Target (SAM) Effects of Herbal Medicines

Molecules
The philosophy of herbal medicines is that they contain multiple active components that target many aspects of a given disease. This is in line with the recent multiple-target strategy adopted due to shortcomings with the previous “magic bullet”, single ...
Sean P. Rigby
doaj   +1 more source

Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family [PDF]

, 2014
Kinesins are responsible for a wide variety of microtubule-based, ATP-dependent functions. Their motor domain drives these activities but the molecular adaptations that specify these diverse and essential cellular activities are poorly understood.
Goulet, Adeline, Grossmann, S.P., Jung, Y., Major, J., Moores, Carolyn A., Rosenfeld, S.S.   +5 more
core   +3 more sources

Molecular Targets and Mechanisms of Hedyotis diffusa-Scutellaria barbata Herb Pair for the Treatment of Colorectal Cancer Based on Network Pharmacology and Molecular Docking [PDF]

, 2022
Zhenpeng Yang, Shuai Lu, Huazhen Tang, Jinxiu Qu, Bing Wang, Yuying Wang, Guofeng Pan, Benqiang Rao   +7 more
openalex   +1 more source

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

Evaluation of a novel virtual screening strategy using receptor decoy binding sites [PDF]

, 2016
Virtual screening is used in biomedical research to predict the binding affinity of a large set of small organic molecules to protein receptor targets.
Kukol, A., Kukol, A., Patel, H., Patel, H.   +3 more
core   +2 more sources

The Anisotropic Adsorption of De Novo Allosteric Two‐Component Protein Fibers on Mica Surfaces

Advanced Functional Materials, EarlyView.
In this study, the interfacial behavior of de novo designed proteins that self‐assemble into tubular architectures with distinct morphologies — small (S), large (L), and helical (H) fibers — at the muscovite mica‐water interface is explored using in situ AFM. Abstract Protein adsorption at solid–liquid interfaces underlies many biomedical and materials
Chenyang Shi, Hao Shen, Yuna Bae, Jaeyoung Heo, Shuai Zhang, Lehan Yao, David Baker, James J De Yoreo   +7 more
wiley   +1 more source

Clinical, immunological and molecular findings of patients with DOCK‐8 deficiency from India [PDF]

, 2023
Vijaya Gowri, Akshaya Chougule, Maya Gupta, Prasad Taur, Vaishnavi V. Iyengar, Meena Sivasankaran, Deenadayalan Munirathnam, Sushma Krishna, Umair Ahmed Bargir, Aparna Dalvi, Priyanka Setia, Neha Jodhawat, Shweta Shinde, Shakuntala Prabhu, Minnie Bodhanwala, Manisha Madkaikar, Mukesh Desai   +16 more
openalex   +1 more source