Results 101 to 110 of about 4,323,150 (379)

Substrate specificity provides insights into the sugar donor recognition mechanism of O-GlcNAc transferase (OGT). [PDF]

, 2013
O-Linked β-N-acetylglucosaminyl transferase (OGT) plays an important role in the glycosylation of proteins, which is involved in various cellular events.
Chen, Xi, Chen, Yi, Li, Lei, Liu, Pi, Liu, Xiaoyan, Ma, Xiaofeng, Muthana, Musleh M, Sun, Hong, Wang, Peng G, Yan, Hui, Zhang, Lianwen, Zhou, Feng   +11 more
core   +2 more sources

Tomatidine and Patchouli Alcohol as Inhibitors of SARS-CoV-2 Enzymes (3CLpro, PLpro and NSP15) by Molecular Docking and Molecular Dynamics Simulations

International Journal of Molecular Sciences, 2021
Considering the current dramatic and fatal situation due to the high spreading of SARS-CoV-2 infection, there is an urgent unmet medical need to identify novel and effective approaches for prevention and treatment of Coronavirus disease (COVID 19) by re ...
Rafat Zrieq, I. Ahmad, Mejdi Snoussi, E. Noumi, M. Iriti, F. Algahtani, H. Patel, Mohd Saeed, M. Tasleem, S. Sulaiman, Kaïss Aouadi, Adel Kadri   +11 more
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Demonstrating molecule docking skills through e-module based on blended learning of a la carte model on higher education

JPBI (Jurnal Pendidikan Biologi Indonesia)
Blended learning in higher education is evolving to be more personalized, diverse, innovative, student-centered, and high-quality. It presents an opportunity to redesign and enhance curricula.
Hanum Isfaeni, S. Supriyatin, Reza Mahardika, Mutiara Hasna Putri Suri, Sekar Darmastuti   +4 more
doaj   +1 more source

Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity. [PDF]

, 2019
Kinesin force generation involves ATP-induced docking of the neck linker (NL) along the motor core. However, the roles of the proposed steps of NL docking, cover-neck bundle (CNB) and asparagine latch (N-latch) formation, during force generation are ...
Budaitis, Breane G, Grant, Barry J, Jariwala, Shashank, Lang, Matthew J, Reinemann, Dana N, Scarabelli, Guido, Schimert, Kristin I, Sept, David, Verhey, Kristen J   +8 more
core   +1 more source

Rule-based Modelling and Tunable Resolution [PDF]

, 2009
We investigate the use of an extension of rule-based modelling for cellular signalling to create a structured space of model variants. This enables the incremental development of rule sets that start from simple mechanisms and which, by a gradual ...
Russ Harmer, S. Barry Cooper, Vincent Danos   +2 more
core   +5 more sources

Exploring the mechanisms underlying the therapeutic effect of Salvia miltiorrhiza in diabetic nephropathy using network pharmacology and molecular docking

Bioscience Reports, 2021
The mechanisms underlying the therapeutic effect of Salvia miltiorrhiza (SM) on diabetic nephropathy (DN) were examined using a systematic network pharmacology approach and molecular docking.
Lili Zhang, Lin Han, Xinmiao Wang, Yu Wei, Jinghui Zheng, Linhua Zhao, X. Tong   +6 more
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Introducing a two‐dimensional graph of docking score difference vs. similarity of ligand‐receptor interactions

Indonesian Journal of Biotechnology, 2021
Observation of molecular docking results was generally performed by analyzing the docking score and the interacting amino acid residues separately either in tables or graphs.
Mohammad Rizki Fadhil Pratama, Hadi Poerwono, Siswandono Siswodihardjo   +2 more
doaj   +1 more source

The Versatile Molecular Complex Component LC8 Promotes Several Distinct Steps of Flagellar Assembly [PDF]

, 2012
LC8 is present in various molecular complexes. However, its role in these complexes remains unclear. We discovered that although LC8 is a subunit of the radial spoke (RS) complex in Chlamydomonas flagella, it was undetectable in the RS precursor that is ...
Anjali Gupta, Barbar, Bergen, Bloch, Dennis R. Diener, DiBella, Diener, Diener, Dymek, Dymek, Espindola, Fejtova, Gaillard, Hall, Harris, Heuser, Huang, Jaffrey, Jivan, Joel L. Rosenbaum, Johnson, Kamiya, Kindle, King, LeDizet, Liang, Lightcap, Lin, Lo, Lo, Luo, Naisbitt, Navarro-Lérida, Nicastro, Patel-King, Pazour, Pazour, Pfister, Pigino, Pinfen Yang, Piperno, Piperno, Porter, Priyanka Sivadas, Puthalakath, Qin, Rodríguez-Crespo, Rompolas, Sakato, Segal, Stelter, Summers, Tan, Warner, Wei, Williams, Wirschell, Yang, Yang, Yang, Yang, Yang   +61 more
core   +2 more sources