Results 181 to 190 of about 4,335,438 (378)

Cytotoxic Evaluation, Molecular Docking, and 2D-QSAR Studies of Dihydropyrimidinone Derivatives as Potential Anticancer Agents [PDF]

, 2022
Reem Altaf, Humaira Nadeem, Umair Ilyas, Jamshed Iqbal, Rehan Zafar Paracha, Hajra Zafar, Ana Cláudia Paiva‐Santos, Muhammad Sulaiman, Faisal Raza   +8 more
openalex   +1 more source

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source

Uncovering the molecular targets of phytocannabinoids: mechanistic insights from inverse molecular docking fingerprint approaches

Frontiers in Pharmacology
IntroductionAmong diverse chemical profile of Cannabis sativa L., over 100 phytocannabinoids have been identified. The major cannabinoids Δ-9-THC and CBD are well-studied, with approved palliative and therapeutic applications such as appetite stimulation,
Vid Ravnik, Marko Jukič, Marko Jukič, Veronika Furlan, Uroš Maver, Uroš Maver, Jan Rožanc, Urban Bren, Urban Bren, Urban Bren   +9 more
doaj   +1 more source

Applications of Molecular Docking in Natural Products-Based Drug Discovery

Scientific African, 2023
Isaac Asiamah, S. Obiri, Woasiedem Tamekloe, F. A. Armah, L. S. Borquaye   +4 more
semanticscholar   +1 more source

Gut Bacteria Improve Depressive Symptoms by Degrading Cortisol into Androgen

Advanced Science, EarlyView.
Chronic stress is an important risk factor for stress‐related disorders such as depression. Stress hormone cortisol is essential for the pathogenesis of stress‐related disorders such as depression. Some gut microbiota degraded cortisol, and improve depressive symptoms.
Xiong Wang, Qing Wu, Hao‐Long Zeng, Yin Shen, Hong‐Han Zhang, Jun Gong, Qi Zhang, Jia‐Zhao Xie, Da‐Wei Ye, Zi‐Yong Sun, Zhong‐Chun Liu, Li‐Ming Cheng, Di Li   +12 more
wiley   +1 more source

Synthesis, In silico Molecular Docking Studies and antimicrobial evaluation of Some New Anthracene Derivatives Tagged with Arylidene, Pyridine, Oxazole, and Chromene Moieties as Promising Inhibitors of Bacterial DNA gyrase

, 2022
Hemat M. Dardeer, Ahmed E. Taha, Arafat Toghan, Aboubakr H. Abdelmonsef, M Schiel, G Silbestri, M Alvarez, C Domini, R Gujjarappa, M Albratty, H Alhazmi, A Abu-Hashem, U Fathy, M Gouda, S Mishra, S Patel, C Halpani, T Orlando, P Salbego, F Farias, G Weimer, J Copetti, H Bonacorso, N Zanatta, M Hoerner, J Bern, M Martins, H Rashdan, A Abdel-Aziem, D El-Naggar, S Nabil, M Kasthuri, C Li, K Verma, O Russell, L Dickson, L Mccormick, L Bassit, F Amblard, R Schinazi, M Asif, M Imran, Abida, Y Nayak, S Gaonkar, E Saleh, H Trivedi, V Joshi, B Patel, L Turones, A Martins, L Moreira, S Da, J Fajemiroye, E Costa, A Moustafa, H El-Sayed, S El Rayes, H Morsy, S Abd-Allah, H Ismail, Abd El-Aal, M, Y Wu, Z Guo, W Deng, J Wang, Sd, S Dasari, S Tondepu, L Vadali, N Seelam, T Yakantham, R Sreenivasulu, G Alluraiah, M Tej, R Ramesh Raju, H Saadati-Moshtaghin, B Maleki, R Tayebee, S Kahrobaei, F Abbasinohoji, A Donaire-Arias, A Montagut, R Puig De La Bellacasa, R Estrada-Tejedor, J Teixid, J Borrell, G Singh, ; Diksha, Mohit, P Acharya, D Jethava, M Vasava, Z Bhavsar, M Bhoi, D Rajani, H Patel, S Jindal, K Meena   +99 more
openalex   +1 more source

Curcumin Suppresses Lead-Induced Inflammation and Memory Loss in Mouse Model and In Silico Molecular Docking [PDF]

, 2022
Suksan Changlek, Mohammad Nasiruddin Rana, Moe Pwint Phyu, Naymul Karim, Hideyuki J. Majima, Jitbanjong Tangpong   +5 more
openalex   +1 more source

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

Advanced Science, EarlyView.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu, Xinlin Xu, Yue Tong, Min Wang, Feng Ge, Min Wu, Yunlong Wang, Gang Chen, Xilan Yu, Shanshan Li   +9 more
wiley   +1 more source

New insights in series of ligands used as SARS-CoV-2 virus inhibitors within molecular docking, molecular quantum similarity, and chemical reactivity indices frameworks

, 2022
Alejandro Morales‐Bayuelo
openalex   +1 more source

HPD is an m6A Methyltransferase that Protects Colorectal Cancer Cells from Ferroptotic Cell Death by m6A Methylating SLC7A11/GPX4

Advanced Science, EarlyView.
This study reveals that the tyrosine metabolic enzyme HPD functions as a previously uncharacterized, METTL3‐independent m6A methyltransferase. It promotes colorectal tumor progression by coordinately regulating the SLC7A11/GPX4 axis to suppress ferroptosis.
Jiyan Wang, Xintong Dai, Huanle Liu, Saiwei Hua, Hongkai Chang, Huanran Sun, Mingming Sun, Huifang Zhao, Kemin Ni, Fei Xie, Yaya Qiao, Qingle Gao, Chenxi Yu, Qijun Zhang, Jianshuang Guo, Chunze Zhang, Shuai Zhang, Changliang Shan   +17 more
wiley   +1 more source