Results 201 to 210 of about 4,323,150 (379)

HPD is an m6A Methyltransferase that Protects Colorectal Cancer Cells from Ferroptotic Cell Death by m6A Methylating SLC7A11/GPX4

Advanced Science, EarlyView.
This study reveals that the tyrosine metabolic enzyme HPD functions as a previously uncharacterized, METTL3‐independent m6A methyltransferase. It promotes colorectal tumor progression by coordinately regulating the SLC7A11/GPX4 axis to suppress ferroptosis.
Jiyan Wang, Xintong Dai, Huanle Liu, Saiwei Hua, Hongkai Chang, Huanran Sun, Mingming Sun, Huifang Zhao, Kemin Ni, Fei Xie, Yaya Qiao, Qingle Gao, Chenxi Yu, Qijun Zhang, Jianshuang Guo, Chunze Zhang, Shuai Zhang, Changliang Shan   +17 more
wiley   +1 more source

Immunomodulatory effects of QsCATH on macrophages: transcriptomic insights and molecular docking analysis. [PDF]

Sci Rep
Qiao F, Qian XY, Wu JL, Wang ZX, Feng YK, Chen J.   +5 more
europepmc   +1 more source

TREM2 Drives Neutrophil Extracellular Traps‐Induced Dendritic Cell Maturation and Contributes to Lupus Progression

Advanced Science, EarlyView.
TREM2 recognizes NETs‐derived MPO to promote DC maturation and antigen presentation, thereby exacerbating the autoimmune response in SLE. Mechanistically, TREM2 activation triggers the DAP12/SYK/ERK cascade and enhances NETs internalization by DCs, which in turn activates the cGAS/STING signaling pathway.
Jingxian Shu, Jiabi Liang, Linda Zeng, Shuping Zhong, Xueling Fang, Yating Xu, Yongjian Wu, Xi Huang   +7 more
wiley   +1 more source

Unraveling the mechanisms of nicotine-induced osteoporosis via network toxicology, bioinformatics, and molecular docking. [PDF]

Tob Induc Dis
Xu S, Wang G, Liu J, Zhang X, Dong X, Liang J, Bai T.   +6 more
europepmc   +1 more source

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source

Correction: Microplastic exposure and allergic rhinitis: Network toxicology, and molecular docking insights. [PDF]

PLoS One
Wang Y, Xu D.
europepmc   +1 more source

A Molecular Bridge-Like Binding Mode of Buspirone to Bsa: Multispectroscopic and Molecular Docking Investigation

, 2022
Shakuntala S. Sawant, Vidya Patil, Sandip Labade, Chandrakant Khilare   +3 more
openalex   +1 more source

A GLUTAMATE CYSTEINE LIGASE Gene StGSH1 Regulated by StERF10 Enhanced Glutathione Accumulation and Adaptation to Low Phosphorus Stress in Potato

Advanced Science, EarlyView.
The StERF10‐StGSH1 module coordinates glutathione (GSH) biosynthesis under low‐phosphorus stress. The low‐phosphate‐induced AP2/ERF transcription factor StERF10 directly activates the transcription of StGSH1 and enhances GSH accumulation. Consequently, GSH scavenges reactive oxygen species and provides sulfur for sulfolipid synthesis, facilitating the ...
Xiaocheng Tian, Mingjun Li, Xiaojia Huang, Markus Wirtz, Xiaohui Zheng, Shilong Fan, Jiang Tian, Shaoqun Liu, Zhonghua Liu, Hongbo Zhao   +9 more
wiley   +1 more source

Molecular Docking as a Key Driver of Biocontrol for Agri-Food Security. [PDF]

BioTech (Basel)
Iñiguez-Luna MI, Cadena-Zamudio JD, Ramírez-Mosqueda MA, Aguirre-Noyola JL, Cadena-Zamudio DA, Cadena-Iñiguez J, Armenta-Medina A.   +6 more
europepmc   +1 more source

Molecular Dynamics and Docking Studies on Acetylcholinesterase (AChE) Inhibitors [PDF]

, 2018
Rejwan Ali, Mostafa Sadoqi, Simon Geir Møller, Allal Boutajangout, Mihaly Mezei   +4 more
openalex   +1 more source