Results 201 to 210 of about 410,977 (285)

TREM2 Drives Neutrophil Extracellular Traps‐Induced Dendritic Cell Maturation and Contributes to Lupus Progression

Advanced Science, EarlyView.
TREM2 recognizes NETs‐derived MPO to promote DC maturation and antigen presentation, thereby exacerbating the autoimmune response in SLE. Mechanistically, TREM2 activation triggers the DAP12/SYK/ERK cascade and enhances NETs internalization by DCs, which in turn activates the cGAS/STING signaling pathway.
Jingxian Shu, Jiabi Liang, Linda Zeng, Shuping Zhong, Xueling Fang, Yating Xu, Yongjian Wu, Xi Huang   +7 more
wiley   +1 more source

Exploring the Therapeutic Potential of Ginseng in Diabetic Retinopathy: A Network Pharmacology and Molecular Docking Study. [PDF]

Appl Bionics Biomech
Fu Y, Liu C, Xu G, Zhou C.
europepmc   +1 more source

Molecular docking and molecular dynamic simulation studies to identify potential terpenes against Internalin A protein of Listeria monocytogenes

K Deepasree, Subhashree Venugopal
openalex   +1 more source

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source

Molecular docking and dynamics simulation of antimicrobial peptides against adhesion proteins of peri-implant pathogens. [PDF]

Sci Rep
Sasany R, Alizadeh A, Mosaddad SA, Diaz P.   +3 more
europepmc   +1 more source

Structural analysis of catalase from two Musa accessions, FHIA18 and Williams, and from Ravenala madagascariensis [PDF]

, 2008
Jaufeerally-Fakim, Y., Khroyratty, S.S.S., Souza, M.T.   +2 more
core   +1 more source

A GLUTAMATE CYSTEINE LIGASE Gene StGSH1 Regulated by StERF10 Enhanced Glutathione Accumulation and Adaptation to Low Phosphorus Stress in Potato

Advanced Science, EarlyView.
The StERF10‐StGSH1 module coordinates glutathione (GSH) biosynthesis under low‐phosphorus stress. The low‐phosphate‐induced AP2/ERF transcription factor StERF10 directly activates the transcription of StGSH1 and enhances GSH accumulation. Consequently, GSH scavenges reactive oxygen species and provides sulfur for sulfolipid synthesis, facilitating the ...
Xiaocheng Tian, Mingjun Li, Xiaojia Huang, Markus Wirtz, Xiaohui Zheng, Shilong Fan, Jiang Tian, Shaoqun Liu, Zhonghua Liu, Hongbo Zhao   +9 more
wiley   +1 more source

Mechanistic decoding of triclosan-induced endometriosis via network toxicology, Mendelian randomization, and molecular docking. [PDF]

BMC Pharmacol Toxicol
Xu B, Li M, Zhao X, Qin Y, Zhao Y.
europepmc   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Network pharmacology and molecular docking analysis of Yishenqingzhuo oral liquid for chronic kidney disease. [PDF]

Medicine (Baltimore)
Zhao A, Qiu Y, Chen B, Dai S, Zhang W.
europepmc   +1 more source