Results 221 to 230 of about 410,977 (285)

A Novel FGFR3‐Targeting Antibody‐Drug Conjugate Induces Tumor Cell Apoptosis through the cGAS–STING Pathway in Bladder Cancer

Advanced Science, EarlyView.
LZU‐WZLYCS01 is a novel FGFR3‐targeting ADC for bladder cancer with 7‐ethyl‐9‐fluorocamptothecin (A2) as its cytotoxic payload. LZU‐WZLYCS01 intracellularly releases A2, which targets MAD2L1 to activate the cGAS‐STING pathway and induce tumor cell apoptosis.
Shu Cui, Xiongfei Luo, Guangrui Fan, Jingqi Jiang, Yingru Wang, Enguang Yang, Jinpeng Ma, Ze Zhang, Yuhan Wang, Juan Wang, Dengtuo Wang, Hanzhang Wang, Liang Cheng, Junqiang Tian, Zhilong Dong, Yingqian Liu, Zhiping Wang   +16 more
wiley   +1 more source

Mechanisms of Okanin against wound healing based on network pharmacology, molecular docking and molecular dynamics simulation. [PDF]

Sci Rep
Zhao C, Li Y, Lin J, Chen Y, Zeng J, Wang Z, You Z, Chen Y, Zhang W, Huang J, Xie Y, Wu X, Shi R, Wang J.   +13 more
europepmc   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Development, Molecular Docking, and Anti-Anemia Potential of Polyherbal Formulation. [PDF]

Biology (Basel)
Bharati D, Nirhali S, Puri A, Mohite P, Singh S.   +4 more
europepmc   +1 more source

CSN6 Promotes Pancreatic Cancer Progression and Gemcitabine Resistance via Antagonizing DCAF1‐Mediated Ubiquitination of NPM1

Advanced Science, EarlyView.
COP9 signalosome subunit 6 (CSN6) promotes the auto‐ubiquitination and degradation of DDB1‐CUL4 associated factor 1 (DCAF1), thereby antagonizing DCAF1‐mediated ubiquitination of Nucleophosmin (NPM1). This stabilization of NPM1 enhances the ribosome biogenesis process and the translation of specific gemcitabine‐resistance proteins, ultimately driving ...
Yijing Zhang, Han Gao, Aiwen Tang, Haiwen Lyu, Zongmin Fan, Jiahui Guo, Yuzhi Wang, Hairong Yi, Qihao Pan, Haidan Luo, Baifu Qin, Boyu Zhang, Xiangqi Meng, Qingxin Liu, Mong‐Hong Lee   +14 more
wiley   +1 more source

Exploring the mechanism of PFTrDA on human hepatic metabolic diseases based on network toxicology and molecular docking. [PDF]

Sci Rep
Li Z, Guo C, Wang T, Weng L.
europepmc   +1 more source

A review of phytochemical-based antiepileptic agents: Insights from molecular docking studies

Shibani Raut, Akshya Ku Mishra
openalex   +1 more source

Quantification of Antibiotic Diffusion in Biofilms Using Gold Nanostar Surface‐enhanced Raman Spectroscopy

Advanced Science, EarlyView.
Gold nanostar‐enhanced Raman spectroscopy (SERS) enables real‐time, label‐free tracking of levofloxacin diffusion in intact biofilms. Nanostars embedded 16 µm below the surface detect drug arrival over time, revealing the impact of the biofilm matrix on antibiotic transport. Abstract The increased resistance to antibiotics shown by bacteria in biofilms
Wafaa Aljuhani, Yingrui Zhang, Matthew P. Wylie, Colin P. McCoy, Steven E. J. Bell   +4 more
wiley   +1 more source

Synthesis, antimicrobial evaluation, and computational investigation of new triazine-based compounds via DFT and molecular docking. [PDF]

Sci Rep
Hussain AO, Hassan AY, Abdel-Aziem A, Abou-Amra ES.   +3 more
europepmc   +1 more source

α-Glucosidase inhibitory activity, molecular docking, QSAR and ADMET properties of novel 2-amino-phenyldiazenyl-4H-chromene derivatives

, 2016
Onkara Perumal, Sagar Vijay Kumar Peddakotla, Lingala Suresh, G. V. P. Chandramouli, Y. Pydisetty   +4 more
openalex   +1 more source