Results 231 to 240 of about 4,190,416 (396)

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Synthesis, Binding Affinity, and Molecular Docking Analysis of New Benzofuranone Derivatives as Potential Antipsychotics [PDF]

, 2008
Reyes Aranda, Karen Villalba, Enrique Raviña, Christian F. Masaguer, José Brea, Filipe Areias, Eduardo Domínguez, Jana Selent, Laura López, Ferrán Sanz, Manuel Pastor, Marı́a Isabel Loza   +11 more
openalex   +1 more source

Pharmacological Dissection Identifies Retatrutide Overcomes the Therapeutic Barrier of Obese TNBC Treatments through Suppressing the Interplay between Glycosylation and Ubiquitylation of YAP

Advanced Science, Volume 12, Issue 11, March 20, 2025.
This study reveals that obesity‐driven metabolic dysfunction enhances YAP O‐GlcNAcylation, facilitating its stabilization by preventing ubiquitylation and degradation via EIF3H, thereby driving TNBC progression and chemoresistance. Retatrutide disrupts this axis by suppressing O‐GlcNAcylation, restoring YAP ubiquitylation, and enhancing degradation ...
Xin Cui, Yueming Zhu, Lidan Zeng, Mengyuan Zhang, Amad Uddin, Theresa W. Gillespie, Lauren E. McCullough, Shaying Zhao, Mylin A. Torres, Yong Wan   +9 more
wiley   +1 more source

Docking problem between 3-dimensional electron microscopic image and atomic model : An approach to solution by molecular dynamics analysis

, 2003
Kazuki Noda, Takuo Yasunaga
openalex   +2 more sources

Molecular Modeling and Docking Analysis of Entamoeba histolytica Glyceraldehyde‐3 Phosphate Dehydrogenase, A Potential Target Enzyme for Anti‐Protozoal Drug Development [PDF]

, 2008
Shailza Singh, Balwant K. Malik, Durlabh Kumar Sharma   +2 more
openalex   +1 more source

Geniposidic Acid Targeting FXR “S332 and H447” Mediated Conformational Change to Upregulate CYPs and miR‐19a‐3p to Ameliorate Drug‐Induced Liver Injury

Advanced Science, Volume 12, Issue 15, April 17, 2025.
Drug abuse exacerbates cholesterol and bile acids burden, causing liver injury. Geniposidic acid targets FXR Ser332 and His447, together with SRC2‐3 recruitment and activated FXR nuclear translocation. Geniposidic acid‐activated FXR can upregulate CYPs to accelerate bile acids clearance and activate miR‐19a‐3p to suppress LXR‐mediated cholesterol ...
Minqi Fan, Yuanhang Xu, Bingxin Wu, Jiachan Long, Caihong Liu, Zuhui Liang, Rong Zhang, Zhongqiu Liu, Caiyan Wang   +8 more
wiley   +1 more source

Inhibition of Aberrant Activated Fibroblast‐Like Synoviocytes in Rheumatoid Arthritis by Leishmania Peptide via the Regulation of Fatty Acid Synthesis Metabolism

Advanced Science, EarlyView.
LACK156‐173 is internalized into RA‐FLSs via CAPN2‐mediated endocytosis and inhibits the aggressive phenotype of RA‐FLSs by restoring dysregulated fatty acid synthesis metabolism mediated by overexpressed FASN. The findings suggest that targeting the restoration of fatty acid metabolism could potentially alleviate synovial invasion and joint damage in ...
Jianling Su, Xuemei Fan, Yaoyao Zou, Guangtao Fu, Shiqi Feng, Xiaoxue Wang, Yongmei Yu, Lin Li, Zhenhua Bian, Rongrong Huang, Linmang Qin, Jiping Chen, Qin Zeng, Kai Yan, Caiyue Gao, Zhexiong Lian, Xin Li, Yang Li   +17 more
wiley   +1 more source

Modelling the structure of latexin–carboxypeptidase A complex based on chemical cross-linking and molecular docking

, 2005
Dmitri Mouradov, A.C.C. Craven, Jade K. Forwood, Jack U. Flanagan, Raquel García-Castellanos, F. Xavier Gomis‐Rüth, David Hume, Jennifer L. Martin, Boštjan Kobe, Thomas Huber   +9 more
openalex   +2 more sources

An efficient and accurate molecular alignment and docking technique using ab initio quality scoring [PDF]

, 2008
László Füsti-Molnár, Kenneth M. Merz
openalex   +1 more source

Elevated SPARC Disrupts the Intestinal Barrier Integrity in Crohn's Disease by Interacting with OTUD4 and Activating the MYD88/NF‐κB Pathway

Advanced Science, Volume 12, Issue 11, March 20, 2025.
This study reveals that SPARC activates the MYD88/NF‐κB/MLCK/MLC2 pathway by interacting directly with OTUD4, leading to intestinal barrier damage. In addition, the METTL3‐YTHDF1 axis promotes SPARC expression. Therefore, targeting SPARC or the OTUD4/MYD88/NF‐κB/MLCK/MLC2 axis may provide new insights into the molecular basis of CD and may serve as an ...
Jiayu Wang, Yuxin He, Xingchao Zhu, Jinghan Zhu, Zilin Deng, Huan Zhang, Yanjun Chen, Guangbo Zhang, Tongguo Shi, Weichang Chen   +9 more
wiley   +1 more source