Results 231 to 240 of about 410,977 (285)

MSC Membrane‐Coated circPROSC‐siRNA Nanoparticles for Ameliorating Craniosynostosis by Inhibiting Premature Suture Ossification

Advanced Science, EarlyView.
CircPROSC promotes craniosynostosis by sponging miR‐6815‐5p, thereby activating WNT3A/β‐catenin signaling and enhancing RUNX2‐mediated osteogenesis. Targeted silencing of circPROSC with MSC membrane–coated siRNA nanoparticles (MM@Lipo/si‐circPROSC) delivered postnatally into cranial sutures attenuates premature suture closure in Twist1+/– mice ...
Zhenkun Weng, Xiu Chen, Jin Xu, Qing Yan, Jian Jiao, Qian Liu, Aihua Gu   +6 more
wiley   +1 more source

Searching for Hypoglycemic Compounds from Brazilian Medicinal Plants Through UPLC-HRMS and Molecular Docking. [PDF]

Plants (Basel)
Batista EM, Freire GA, Martins CBR, Xavier Filho RRB, Silva GSD, Alencar NMN, Ribeiro PRV, Martins NF, Milhome YA, Santos HSD, Frederico MJS, Oliveira LS, Canuto KM.   +12 more
europepmc   +1 more source

In silico identification of potential inhibitors for the universal stress G4LZI3 protein from Schistosoma mansoni using molecular docking and molecular dynamics simulation analyses

Lihle Mahamba, Mustafa Alhaji Isa, Abidemi Paul Kappo   +2 more
openalex   +1 more source

EM2, a Natural Product MST1/2 Kinase Activator, Suppresses Non‐Small Cell Lung Cancer via Hippo Pathway Activation

Advanced Science, EarlyView.
EM2 directly binds to and activates MST1/2, enhancing their kinase activity and sequentially promoting LATS phosphorylation, which increases YAP phosphorylation. Consequently, YAP nuclear translocation is suppressed, leading to reduced transcription of downstream targets CTGF and CYR61, ultimately exerting a robust inhibitory effect on NSCLC cell ...
Siyu Yang, Huayan Xie, Qiang Lin, Liujin Zhou, Junxi Liu, Zekai Fang, Ziling Tang, Ruijie Yuan, Jinxuan Su, Sijia Li, Wenlin Wang, Mingyu Pan, Hao Wang, Xiaoyong Dai, Guocai Wang, Yubo Zhang   +15 more
wiley   +1 more source

Molecular Docking of Detoxification Enzymes from <i>Oides leucomelaena</i> with Volatiles of Star Anise. [PDF]

Biology (Basel)
Yang Y, Zhang Z, Ma H, Hu L, Li K, Zhao N, Liu L, Zhou J.   +7 more
europepmc   +1 more source

Novel Al(OH)3 and Ti/Fe@Al(OH)3 nano catalyzed of N-(3-((E)-3-(4-Adamant-1-yl)-phenyl) acryloyl) phenyl) quinoline-2-carboxamide Synthesis and its Molecular Docking, Quantum chemical Studies

C. Thirumurugan, R. Thirumalaisamy, Appaswami Lalitha, P. Vadivel, Selva Kumar Ramasamy, Kalandar Ameer, Ramalingam Karthik Raja, Shyam Kumar Rajaram, Ponmurugan Karuppiah   +8 more
openalex   +1 more source

Targeting NRP1 in Endothelial Cells Facilitates the Normalization of Scar Vessels and Prevents Fibrotic Scarring

Advanced Science, EarlyView.
Scars exhibit vascular abnormal alterations, including upregulated NRP1 expression in endothelial cells, increased vascular density and branching, compromised vessel wall integrity, and incomplete pericyte coverage. Therapeutic targeting of NRP1 through hydrogel spray delivery offers a promising approach to normalize aberrant vasculature and prevent ...
Yu Wang, Xin Zhou, Min Liu, Meimei Huang, Peirong Chen, Xinying Li, Fangchao Xue, Wenyan Zhao, Di Liu, Lang Li, Yuangang Lu, Wen Zeng   +11 more
wiley   +1 more source

Network Pharmacology and Molecular Docking Reveal Neuroprotective Potential of <i>Ligusticum wallichii</i> in Alzheimer's Disease Therapy. [PDF]

Neuropsychiatr Dis Treat
Zhou C, Peng Y.
europepmc   +1 more source

Identification of a novel and high affinity MIF inhibitor via structure-based pharmacophore modelling, molecular docking, molecular dynamics simulations, and biological evaluation

Shang Zhu, Shudan Yang, Yao Chen, Miaomiao Niu, Jun Wang, Jindong Li, Xuehua Pu   +6 more
openalex   +1 more source

Phytochemical Analysis of Semen Hoveniae and Its Potential Mechanism Against Alcoholic Liver Disease via an Integrated Approach Combining UHPLC‐Q‐TOF MS, Network Pharmacology, and Molecular Docking [PDF]

Min Li, Zhuo‐chun Wei, Feng‐Xiang Zhang, Haijun Li   +3 more
openalex   +1 more source