Results 251 to 260 of about 4,323,150 (379)

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

Network pharmacology and molecular docking to explore the potential mechanism of Codonopsis pilosula delaying aging. [PDF]

Medicine (Baltimore)
Liu J, Zhang X, Jing X, Wang W, Li K.
europepmc   +1 more source

Identification of the antiepileptic racetam binding site in the vesicle synaptic protein 2A by molecular dynamics and docking simulations

, 2015
José eCorrea-Basurto, Roberto I. eCuevas-Hernández, Bryan V. ePhillips-Farfán, Marlet eMartínez-Archundia, Antonio eRomo-Mancillas, Gema L. eRamírez-Salinas, Óscar A. ePérez-González, José eTrujillo-Ferrara, Julieta Griselda Mendoza‐Torreblanca   +8 more
openalex   +1 more source

Solubility enhancement and controlled release of anti-viral drug ribavirin via modified β-cyclodextrin inclusion complex nanofibers: experimental and molecular docking studies

Naushad Ahmad, Sonaimuthu Mohandoss, Kuppu Sakthi Velu, Ramachandran Srinivasan, Prasanta Ray Bagdi, Prathap Somu, Dipak Haldar   +6 more
openalex   +1 more source

Evaluation of Fifteen 5,6-Dihydrotetrazolo[1,5-c]quinazolines Against Nakaseomyces glabrata: Integrating In Vitro Studies, Molecular Docking, QSAR, and In Silico Toxicity Assessments [PDF]

Lyudmyla Antypenko, Oleksii Antypenko, Alina Fominichenko, Iryna Karnaukh, С. І. Коваленко, Mieko Arisawa   +5 more
openalex   +1 more source

Novel Antifungal Scaffold Targeting Tubulin Overcomes Sclerotinia Sclerotiorum Resistance

Advanced Science, EarlyView.
Addressing pesticide resistance, novel chromone‐acylhydrazone hybrids targeting fungal tubulin are synthesized. Compound G24 potently inhibited S. sclerotiorum (EC50 = 0.21µg mL−1) and demonstrated enhanced field performance via microencapsulation, offering a sustainable strategy against resistance and for global food security.
Lihui Shao, Xianqun Hu, Ying Wu, Xiang Zhou, Bo Zhang, Song Yang   +5 more
wiley   +1 more source

Molecular mechanism of bisphenol A in promoting esophageal carcinoma based on network toxicology and molecular docking. [PDF]

Medicine (Baltimore)
Hou M, Jia H, Liu C, Wang C.
europepmc   +1 more source

Novel pyrazole-coumarin-linked 1,2,3-triazole conjugates: Synthesis, biological evaluation and molecular docking study

Mininath K. Bhalmode, Mubarak H. Shaikh, Karan Waghmare, Krishna V. Lathi, Nilam D. Bansode, Dhananjay H. More, Ambadas B. Rode, Jaiprakash Sanghshetti, Vijay M. Khedkar, Manoj V. Mane, Bapurao B. Shingate   +10 more
openalex   +1 more source

Network pharmacology and molecular docking study on the potential mechanism of Tongqiao–Biyan granule in treatment of allergic rhinitis [PDF]

Zheying Song, Yujuan Yang, Zhaoxue Zhai, Yu Zhang, Xicheng Song   +4 more
openalex   +1 more source

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

Advanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang, Mengqing Sun, Heng Dong, Xiaoting Zhang, Jingbo Zhang, Zhengguo Zhang, Mengjie Ni, Lina Li, Yunxin Pei, Xiaoyu Chen, Qian Li, Fangtian Bu, Jiacheng Huang, Liangyu Jiang, Zhuting Fang, Xuliang Chen, Jianxiang Chen, Yiting Qiao, Tian Xie   +18 more
wiley   +1 more source