Results 251 to 260 of about 4,335,438 (378)

TriCON: A Carbon‐Based Triple‐Modal Nanoplatform for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
We developed TriCON, a triple‐modality nanotherapeutic platform, to treat pancreatic ductal adenocarcinoma (PDAC) by synergizing gene editing, chemotherapy, and immunotherapy. TriCON utilizes CRISPR/Cas9 to target the poliovirus receptor (PVR), combined with nano‐encapsulated doxorubicin and checkpoint blockade. This approach achieved significant tumor
Xinyu Peng, Jiaxing Huang, Shengnan Lv, Jian Zhang, Liangliang Zhang, Huan Liu, Yan Liu, Zhen‐An Qiao, Feng Wei, Bao‐Lian Su   +9 more
wiley   +1 more source

Thienopyrimidine scaffolds as promising antimicrobial agents: synthesis, biological evaluation, DFT analysis and molecular docking. [PDF]

RSC Adv
Sayed M, Naguib MA, Mohammed AAK, Hassanien R, Tolba MS, Ahmed M.   +5 more
europepmc   +1 more source

Revealing the active ingredients and mechanism of P. sibiricumm in non-small-cell lung cancer based on UPLC-Q-TOF-MS/MS, network pharmacology, and molecular docking

Kaili Guo, Yu Jiang, Wei Qiao, Panpan Yuan, Miao Xue, Jiping Liu, Wei Hao, Bin Wang, Xingmei Zhu   +8 more
openalex   +1 more source

Structural analysis of catalase from two Musa accessions, FHIA18 and Williams, and from Ravenala madagascariensis [PDF]

, 2008
Jaufeerally-Fakim, Y., Khroyratty, S.S.S., Souza, M.T.   +2 more
core   +1 more source

Molecular Docking and Molecular Dynamics [PDF]

, 2019
openaire   +1 more source

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

Advanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen, Jindi Huang, Cong Liu, Shipeng Zhang, Xinze Li, Zhang Zhang, Tie‐Gen Chen, Ling Wang   +7 more
wiley   +1 more source

Exploring the mechanism of cytisine in treating respiratory depression following venomous snake bites based on network pharmacology and molecular docking

Shi‐Ling Sun
openalex   +1 more source

Synthesis, Characterization, Antimicrobial Assessments, Potential Antioxidant and Molecular Docking Studies of Polyfunctional Substituted Azoles, Azines, and their Analogs linked Sulfamethoxazole moiety [PDF]

Ibrahim A. Mousa, Awatef M. Elmaghraby, Hatem E. Gaffer, Marwan Zakariya Yahya, Abdallah M. A. Hassane, Abdel Haleem M. Hussein   +5 more
openalex   +1 more source

Transient Antiskyrmion‐Mediated Topological Transitions in Isotropic Magnets

Advanced Science, EarlyView.
A transient antiskyrmion‐mediated pathway that drives repeated stripe‐to‐skyrmion transitions is revealed, producing a net increase in topological charge in isotropic Dzyaloshinskii–Moriya interaction films. Experiments and simulations identify the antiskyrmion as a metastable excitation, enabling stochastic bitstream generation for probabilistic ...
Bingqian Dai, Tianyi Wang, Albert Lee, Shijie Xu, Zhongjian Bian, Xinyue Zhu, Puyang Huang, Aadi Chaturvedi, Yaochen Li, Yang Cheng, Qingyuan Shu, Haoran He, Hanshen Huang, Lixuan Tai, Kin Wong, Jinbo Yang, Anjan Soumyanarayanan, Zhaochu Luo, Kang L. Wang   +18 more
wiley   +1 more source

Molecular docking and pharmacokinetics of benzimidazole-based FtsZ inhibitors for tuberculosis. [PDF]

Sci Rep
Sonwane PN, Kumbhare MR.
europepmc   +1 more source