Results 261 to 270 of about 4,190,416 (396)

Molecular Docking Studies and Anti−Snake Venom Metalloproteinase Activity of Thai Mango Seed Kernel Extract [PDF]

, 2009
Pimolpan Pithayanukul, Jiraporn Leanpolchareanchai, Patchreenart Saparpakorn   +2 more
openalex   +1 more source

Aging‐induced Alternation in the Gut Microbiota Impairs Host Antibacterial Defense

Advanced Science, Volume 12, Issue 12, March 27, 2025.
Bacterial infections in older individuals often result in worse outcomes, but the mechanisms remain unclear. This study reveals that aging‐induced alterations in gut microbiota impair host antibacterial defense mechanisms, and exacerbate the consequences of bacterial infections.
Peng Gu, Rongjuan Wei, Ruofan Liu, Qin Yang, Yuxuan He, Jianbin Guan, Wenhao He, Jiaxin Li, Yunfei Zhao, Li Xie, Jie He, Qingling Guo, Jiajia Hu, Jingna Bao, Wandang Wang, Jiayin Guo, Zhenhua Zeng, Zhongqing Chen, Yong Jiang, Zhanguo Liu, Peng Chen   +20 more
wiley   +1 more source

Application of bioinformatics analysis and molecular docking to study the mechanism of Qingying decoction in treating psoriasis. [PDF]

Hereditas
Shen C, Liu X, Jia H, Wang W, Wang X, Wang H, Wang D, Li J.   +7 more
europepmc   +1 more source

TRAF3IP3 Induces ER Stress‐Mediated Apoptosis with Protective Autophagy to Inhibit Lung Adenocarcinoma Proliferation

Advanced Science, Volume 12, Issue 17, May 8, 2025.
Schematic diagram of the working model of TRAF3IP3 in the coordination of ER stress and autophagy related apoptosis in lung cancer cells. Abstract TNF receptor‐associated factor 3 interacting protein 3 (TRAF3IP3/T3JAM) exhibits dual roles in cancer progression. While upregulated in most malignancies and critical for immune regulation.
Guang Zhao, Jun Qi, Fang Li, Haotian Ma, Rui Wang, Xiuyi Yu, Yufei Wang, Sida Qin, Jie Wu, Chen Huang, Hong Ren, Boxiang Zhang   +11 more
wiley   +1 more source

Molecular Docking of Lactoferrin with Apoptosis-Related Proteins Insights into Its Anticancer Mechanism. [PDF]

Int J Mol Sci
Angel-Lerma LE, Carrillo-Campos J, Siañez-Estrada LI, Siqueiros-Cendón TS, León-Flores DB, Espinoza-Sánchez EA, Arévalo-Gallegos S, Iglesias-Figueroa BF, Rascón-Cruz Q.   +8 more
europepmc   +1 more source

Molecular Basis of Glucagon-like Peptide 1 Docking to Its Intact Receptor Studied with Carboxyl-terminal Photolabile Probes [PDF]

, 2009
Quan Chen, Delia I. Pinon, Laurence J. Miller, Maoqing Dong   +3 more
openalex   +1 more source

β‐Glucuronidase‐Expressing Lactobacillus reuteri Triggers Irinotecan Enterotoxicity Through Depleting the Regenerative Epithelial Stem/Progenitor Pool

Advanced Science, EarlyView.
XLP mitigated CPT11 mucositis by suppressing GUS‐expressing microbes, notably L. reuteri, and diminishing bacterial GUS activity, consequently reducing SN38 accumulation to protect the intestinal epithelium. This preservation of the mucosal stem cell niche enabled rapid regeneration of secretory lineages such as mucin‐producing goblet cells, which ...
Bei Yue, Ruiyang Gao, Ling Zhao, Donghui Liu, Cheng Lv, Ziyi Wang, Fangbin Ai, Beibei Zhang, Zhilun Yu, Xiaolong Geng, Hao Wang, Kang Wang, Kaixian Chen, Chenghai Liu, Zhengtao Wang, Wei Dou   +15 more
wiley   +1 more source

Chemical Composition, Molecular Docking Analysis, and Biological Properties of <i>Salvia Mirzayanii</i>. [PDF]

Adv Biomed Res
Mahdizadehdehosta R, Shahbazmohammadi H, Moein S, Soltani N, Malekzadeh K, Moein M.   +5 more
europepmc   +1 more source

Insights into docking and scoring neuronal α4β2 nicotinic receptor agonists using molecular dynamics simulations and QM/MM calculations [PDF]

, 2009
Jacopo Sgrignani, Claudia Bonaccini, Giovanni Grazioso, Maurizio Chioccioli, Andrea Cavalli, Paola Gratteri   +5 more
openalex   +1 more source

Applications of Artificial Intelligence in Drug Repurposing

Advanced Science, Volume 12, Issue 14, April 10, 2025.
Artificial intelligence algorithms are transforming drug repurposing by revealing new therapeutic targets and mechanisms. This review highlights the integration of AI frameworks, multimodal datasets, and advanced optimization methods, accelerating the discovery of new indications for existing drugs.
Zhaoman Wan, Xinran Sun, Yi Li, Tianyao Chu, Xueyu Hao, Yang Cao, Peng Zhang   +6 more
wiley   +1 more source