Results 281 to 290 of about 4,323,150 (379)

Molecular docking of secondary metabolites of marine macroalgae Sargassum vulgare against exotoxin A [PDF]

Najme Baghernezhad, Bita Archangi, Ahmad Savari, Faedeh Amini   +3 more
openalex   +1 more source

TriCON: A Carbon‐Based Triple‐Modal Nanoplatform for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
We developed TriCON, a triple‐modality nanotherapeutic platform, to treat pancreatic ductal adenocarcinoma (PDAC) by synergizing gene editing, chemotherapy, and immunotherapy. TriCON utilizes CRISPR/Cas9 to target the poliovirus receptor (PVR), combined with nano‐encapsulated doxorubicin and checkpoint blockade. This approach achieved significant tumor
Xinyu Peng, Jiaxing Huang, Shengnan Lv, Jian Zhang, Liangliang Zhang, Huan Liu, Yan Liu, Zhen‐An Qiao, Feng Wei, Bao‐Lian Su   +9 more
wiley   +1 more source

Identification of potential bladder cancer drug targets through Mendelian randomization and molecular docking. [PDF]

Discov Oncol
Bi C, Li K, Yang Y, Shi Y, Zhang G, Zhao B, Duan Y, Xing Y, Luo W, Yang L, Zhang Y, Huang Y.   +11 more
europepmc   +1 more source

Homology Modelling and Molecular Docking Studies to Discover Potent Inhibitors of CD169 in PRRSV Infection [PDF]

Nsabimana Eliphaz, Wenqiang Cui, Han Xiao, God’spower Bello-Onaghise, Yang Tang, Fei Yu, Feng Zhang, Junjie Qin, Wen-xin Guo, Yànhuá Lǐ   +9 more
openalex   +1 more source

A Dynamic Gate Enables Regioselective Hydroxylation of Free Arginine by a Non‐Canonical Heme Enzyme

Advanced Science, EarlyView.
The YqcI/YcgG enzyme AglA employs a unique “sandwich” fold and a dynamic gating mechanism to selectively hydroxylate AMPn‐Arg at Nε. Site‐directed mutations reprogram regioselectivity or enable activity on free arginine by altering hydrogen‐bond networks, precisely positioning substrates.
Yuan Sun, Chao Dou, Weizhu Yan, Pengpeng Chen, Lu Zhang, Dan Zhou, Yanhui Zheng, Zhaolin Long, Shoujie Li, Xiaoqing Xu, Qiuxia Huang, Xiaofeng Zhu, Wei Cheng   +12 more
wiley   +1 more source

Molecular docking and pharmacological investigations of folenolide for its analgesic, anti-inflammatory, and antipyretic applications. [PDF]

Front Pharmacol
Ali FL, Khuda F, Khan Khalil AA, Jan A, Khan MA, Nadeem A, Rasheed A, Ali SS, Ullah A.   +8 more
europepmc   +1 more source

Affinity‐Based Protein Profiling Revealed that HIGD1A is a Direct Target Protein of Aristolochic Acids

Advanced Science, EarlyView.
Using an affinity‐based probe, this study reveals that aristolochic acid directly binds to HIGD1A with high affinity in the kidney. This binding disrupts the HIGD1A‐TFAM interaction, which in turn triggers TFAM degradation, cytosolic mitochondrial DNA release, and the activation of inflammatory pathways. Abstract Exposure to aristolochic acids (AA) via
Yin Gong, Shanshan Zhang, Anying Wei, Xiang Ji, Xiaodan Chong, Jinfeng Cen, Xuan Zhao, Zimeng Luo, Zhipeng Pei, Guanchao Mao, Xinkang Zhang, Mingxue Sun, Zhiguo Sun, Zifei Yin, Zhengrong Zou, Wen‐Qi Meng   +15 more
wiley   +1 more source

Curcumin Derivatives as Allosteric Modulator of α7-nAChR: Functional and Molecular Docking Insights. [PDF]

Med Princ Pract
ElNebrisi E, Ghattas MA, Atatreh N, Hasan S, Oz M.   +4 more
europepmc   +1 more source

Transient Antiskyrmion‐Mediated Topological Transitions in Isotropic Magnets

Advanced Science, EarlyView.
A transient antiskyrmion‐mediated pathway that drives repeated stripe‐to‐skyrmion transitions is revealed, producing a net increase in topological charge in isotropic Dzyaloshinskii–Moriya interaction films. Experiments and simulations identify the antiskyrmion as a metastable excitation, enabling stochastic bitstream generation for probabilistic ...
Bingqian Dai, Tianyi Wang, Albert Lee, Shijie Xu, Zhongjian Bian, Xinyue Zhu, Puyang Huang, Aadi Chaturvedi, Yaochen Li, Yang Cheng, Qingyuan Shu, Haoran He, Hanshen Huang, Lixuan Tai, Kin Wong, Jinbo Yang, Anjan Soumyanarayanan, Zhaochu Luo, Kang L. Wang   +18 more
wiley   +1 more source