Results 281 to 290 of about 4,190,416 (396)

Membrane Docking Geometry and Target Lipid Stoichiometry of Membrane-Bound PKCα C2 Domain: A Combined Molecular Dynamics and Experimental Study [PDF]

, 2010
Chun-Liang Lai, Kyle E. Landgraf, Gregory A. Voth, Joseph J. Falke   +3 more
openalex   +1 more source

N4‐Acetylcytidine‐Mediated CD2BP2‐DT Drives YBX1 Phase Separation to Stabilize CDK1 and Promote Breast Cancer Progression

Advanced Science, Volume 12, Issue 15, April 17, 2025.
The long non‐coding RNA (lncRNA) CD2BP2‐DT is upregulated in breast cancer and correlates with poor patient prognosis. Mechanistically, CD2BP2‐DT drives YBX1 phase separation to stabilize CDK1 and promote breast cancer progression. Moreover, NAT10‐mediated N4‐acetylcytosine (ac4C) modification further enhances CD2BP2‐DT expression.
Hongyu Wang, Bozhi Zhao, Jiayu Zhang, Qunyu Hu, Linlin Zhou, Yinghui Zhang, Yixin Cai, Yuansong Qu, Tao Jiang, Dongwei Zhang   +9 more
wiley   +1 more source

Synthesis of thiazoloquinolinone derivatives: molecular docking, MD simulation, and pharmacological evaluation as VEGFR-2 inhibitors. [PDF]

BMC Chem
Amiri Z, Bayat M, Gheidari D.
europepmc   +1 more source

Interaction of CTX-M-15 enzyme with cefotaxime: a molecular modelling and docking study [PDF]

, 2010
Shazi Shakil, Asad U. Khan
openalex   +1 more source

Paclitaxel/Luteolin Coloaded Dual‐Functional Liposomes for Esophageal Cancer Therapy

Advanced Science, EarlyView.
The authors develop a pH‐sensitive aptamer‐modified liposome (EA2‐PSL‐PTX/LUT) to illustrate a strategy for the precise delivery of combinational chemotherapeutic drugs for esophageal squamous cell carcinoma (ESCC) targeted therapy. EA2‐PSL‐PTX/LUT provides efficient co‐loading, tumor targeting, and controlled release of luteolin and paclitaxel ...
Congyong Sun, Fei Xie, Huiyun Zhang, Lulu Feng, Yuting Wang, Chaofan Huang, Zhizhen Cui, Chao Luo, Li Zhang, Qilong Wang   +9 more
wiley   +1 more source

Dapagliflozin in Chronic Kidney Disease: Insights from Network Pharmacology and Molecular Docking Simulation. [PDF]

Life (Basel)
Phongphithakchai A, Tedasen A, Netphakdee R, Leelawattana R, Srithongkul T, Raksasuk S, Huang JC, Chatatikun M.   +7 more
europepmc   +1 more source

Computational model of hepatitis B virus DNA polymerase: Molecular dynamics and docking to understand resistant mutations [PDF]

, 2010
Pankaj Daga, Jinsong Duan, Robert J. Doerksen   +2 more
openalex   +1 more source

P21‐Activated Kinase 2 as a Novel Target for Ventricular Tachyarrhythmias Associated with Cardiac Adrenergic Stress and Hypertrophy

Advanced Science, Volume 12, Issue 17, May 8, 2025.
Ca2+/calmodulin‐dependent kinase II (CaMKII) activation is likely driven by oxidative stress, particularly excessive reactive oxygen species (ROS) production. This study identifies P21‐activated kinase 2 (Pak2) as a novel regulator of ROS‐induced CaMKII activation and abnormal Ca2⁺ dynamics in acute adrenergic and chronic pressure‐overload stressed ...
Tao Li, Ting Liu, Yan Wang, Yangpeng Li, Leiying Liu, James Bae, Yu He, Xian Luo, Zhu Liu, Tangting Chen, Xianhong Ou, Dan Zhang, Huan Lan, Juyi Wan, Yan Wei, Fang Zhao, Xin Wang, Tao Li, Christopher L.‐H. Huang, Chunxiang Zhang, Ming Lei, Xiaoqiu Tan   +21 more
wiley   +1 more source

Molecular Docking of Endolysins for Studying Peptidoglycan Binding Mechanism. [PDF]

Molecules
Arakelian AG, Chuev GN, Mamedov TV.
europepmc   +1 more source

Pharmacophore Elucidation and Molecular Docking Studies on 5-Phenyl-1-(3-pyridyl)-1H-1,2,4-triazole-3-carboxylic Acid Derivatives as COX-2 Inhibitors [PDF]

, 2010
Marc Lindner
openalex   +1 more source