Results 291 to 300 of about 4,190,416 (396)

NAD+ Metabolism Reprogramming Drives SIRT1‐Dependent Deacetylation Inducing PD‐L1 Nuclear Localization in Cervical Cancer

Advanced Science, Volume 12, Issue 15, April 17, 2025.
The identification of PD‐L1 localization may be a key factor in the resistance to immunotherapy observed in patients. The discovery that PD‐L1 over expression is regulated by both transcriptional and post‐transcriptional processes. The acetyl‐proteomic analysis that identified SIRT1 as a key player in the deacetylation of histone H3 at lysines 27 and ...
Xinyi Lu, Pingping Jin, Qianyun Tang, Min Zhou, Hanjie Xu, Chen Su, Lei Wang, Feng Xu, Min Zhao, Yongxiang Yin, Jinqiu Zhang, Zhen Jia, Xinrui Peng, Jie Zhou, Lu Wang, Yan Chen, Min Wang, Min Yang, Daozhen Chen, Yu Chen   +19 more
wiley   +1 more source

Mechanistic Insights into 3-Isopropylphenol-Induced Neurotoxicity in Zebrafish: A Network Toxicology and Molecular Docking Approach. [PDF]

Toxics
Gu J, Jin H, Hu J, Wang J, Yin D.
europepmc   +1 more source

Assessing the performance of the molecular mechanics/Poisson Boltzmann surface area and molecular mechanics/generalized Born surface area methods. II. The accuracy of ranking poses generated from docking [PDF]

, 2010
Tingjun Hou, Junmei Wang, Youyong Li, Wei Wang   +3 more
openalex   +1 more source

Perillaldehyde Improves Parkinson‐Like Deficits by Targeting G3BP Mediated Stress Granule Assembly in Preclinical Models

Advanced Science, Volume 12, Issue 14, April 10, 2025.
This study uncovers that stress granules (SGs) are involved in the pathogenesis of Parkinson's disease (PD). Perillaldehyde (PAE) can improve Parkinson‐like deficits in preclinical models by directly binding to G3BP and instigating liquid–liquid phase separation (LLPS) of G3BP.
Minglv Fang, Lingling Luo, Youjia Chen, Ying Liu, Yingxuan Yan, Fei Wang, Yan Zou, Huanhu Zhu, Xiaojun Wu, Zhigang Jin, Cheng Huang, Yu Zhang, Shengjie Fan   +12 more
wiley   +1 more source

Integrated network pharmacology, molecular docking, and animal experiments to reveal the potential mechanism of hesperetin on COPD. [PDF]

Sci Rep
Wang J, Wang H, Kang X, Wang X, Li X, Guo J, Jing X, Chu X, Han X.   +8 more
europepmc   +1 more source

2P-003 Theoretical investigation of enzymatic reaction mechanism by molecular docking and QM/MM-MD simulations(The 46th Annual Meeting of the Biophysical Society of Japan)

, 2008
Yohsuke Hagiwara, Osamu Nureki, Masaru Tateno   +2 more
openalex   +2 more sources

Binding Investigation of Integrin αvβ3 With Its Inhibitors by SPR Technology and Molecular Docking Simulation [PDF]

, 2010
Yaqin Liu, Yuanjiang Pan, Yuhong Xu
openalex   +1 more source

Quorum Sensing Coordinates Carbon and Nitrogen Metabolism to Optimize Public Goods Production in Pseudomonas fluorescens 2P24

Advanced Science, Volume 12, Issue 12, March 27, 2025.
Pseudomonas fluorescens 2P24 utilizes a LasI/LasR‐type quorum sensing (QS) system, MupI/MupR, to regulate carbon and nitrogen metabolism for optimal production of secondary metabolites as public goods, including 2,4‐diacetylphloroglucinol, mupirocin, and siderophores.
Jie Li, Mengxue Nie, Hongguang Ma, Xuanying Tao, Yanxia Sun, Xinyue Tu, Pingping Zhang, Li‐Qun Zhang, Rong Jia, Yong‐Xing He, Nannan Zhang, Honghua Ge   +11 more
wiley   +1 more source

Chemosensitization and Molecular Docking Assessment of Dio-NPs on Resistant Breast Cancer Cells to Tamoxifen. [PDF]

Pharmaceuticals (Basel)
Abd-Elghany AA, Mohamad EA, Alqarni A, Hussein MA, Mansour MS.   +4 more
europepmc   +1 more source

Molecular docking and ligand specificity in fragment-based inhibitor discovery

, 2009
Yu Chen, Brian K. Shoichet
openalex   +2 more sources