Results 311 to 320 of about 4,190,416 (396)

Mechanistic Analysis of Decabromodiphenyl Ether-Induced Neurotoxicity in Humans Using Network Toxicology and Molecular Docking. [PDF]

Neurotox Res
Karakuş F, Kuzu B.
europepmc   +1 more source

GNE‐317 Reverses MSN‐Mediated Proneural‐to‐Mesenchymal Transition and Suppresses Chemoradiotherapy Resistance in Glioblastoma via PI3K/mTOR

Advanced Science, Volume 12, Issue 12, March 27, 2025.
The study identifies MSN as a key regulator of proneural‐to‐mesenchymal transition (PMT) in GSCs, driving resistance to radiotherapy (RT) and temozolomide (TMZ) in glioblastoma (GBM). However, GNE‐317 specifically inhibits MSN, reverses PMT, resensitizes cells to therapy, and shows promise as a targeted strategy to overcome chemoradiotherapy resistance
Yong‐Chang Yang, Xing‐Yu Jin, Ling‐Ling Yang, Xing Xu, Yang Xie, Yi‐Ding Ai, Xin‐Chao Li, Ye‐Cheng Ma, Cheng‐Long Xu, Qi Li, Xiang‐Lian Ge, Tai‐Long Yi, Tao Jiang, Xiao‐Guang Wang, Ying‐Zhe Piao, Xun Jin   +15 more
wiley   +1 more source

Molecular docking analysis of pyrrole derivatives with different breast cancer targets. [PDF]

Bioinformation
Ilango S, K G, Kulothungan VK.
europepmc   +1 more source

Modelado Molecular e Interacción Enzima-Ligando (Docking) de Antiinflamatorios Derivados de 4-Hidroxi 1,2-Benzotiazinas-3-Carboxamidas, 1,1-Dióxido

, 2009
Javier H Gris, Martín A Dragonetti, Beatriz Fernández, Albertina G. Moglioni   +3 more
openalex   +1 more source

Integrative Multi‐Omics Approaches Reveal Selectivity Profiles and Molecular Mechanisms of FIIN‐2, a Covalent FGFR Inhibitor

Advanced Science, Volume 12, Issue 14, April 10, 2025.
Using integrative multi‐omics analyses, this study maps FIIN‐2's targets and signaling networks in liver cancer cells, and identifies covalent AMPKα1 binding as a novel autophagy‐activating mechanism. The findings resolve both on‐target FGFR inhibition and off‐target protein engagement, providing a molecular roadmap to refine covalent kinase inhibitors
Ying Fu, Dandan Zhu, Xiaojuan Chen, Lingzhi Qu, Ming Guo, Shuhong Zhang, Guangyu Xu, Zhuchu Chen, Maoyu Li, Yongheng Chen   +9 more
wiley   +1 more source

Evaluation of the Alkaloids as Inhibitors of Human Acetylcholinesterase by Molecular Docking and ADME Prediction. [PDF]

In Vivo
Negru DC, Bungau SG, Radu A, Tit DM, Radu AF, Nistor-Cseppento DC, Negru PA.   +6 more
europepmc   +1 more source

Metabolic Engineering of Corynebacterium glutamicum for High‐Level Production of 1,5‐Pentanediol, a C5 Diol Platform Chemical

Advanced Science, Volume 12, Issue 13, April 3, 2025.
This study develops an efficient biosynthesis system for 1,5‐pentanediol (1,5‐PDO) in Corynebacterium glutamicum, an important compound for industrial applications. By engineering the l‐lysine degradation pathway, 5‐hydroxyvaleric acid (5‐HV) is synthesized from glucose as a key intermediate.
Yu Jung Sohn, Se‐Yeun Hwang, Haeyoung Lee, Subeen Jeon, Ji Young Park, Jaehyung Kim, Donghyuk Kim, Ki Jun Jeong, Sang Yup Lee, Jeong Chan Joo, Jin‐Byung Park, Si Jae Park   +11 more
wiley   +1 more source

Molecular interaction study of L-Ornithine with bovine serum albumin using spectroscopic and molecular docking methods. [PDF]

Sci Rep
Koundal S, Pathania A, Kour HD, Pathania AR, Kaur J, Juneja B, Sharma GC, Bhowmik A, Santhosh AJ.   +8 more
europepmc   +1 more source

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source

Insights into the Mechanism Underpinning Composite Molecular Docking During the Self-Assembly of Fucoidan Biopolymers with Peptide Nanofibrils. [PDF]

Mar Drugs
Li R, Tai MR, Su XN, Ji HW, Chen JP, Liu XF, Song BB, Zhong SY, Nisbet DR, Barrow CJ, Williams RJ.   +10 more
europepmc   +1 more source