Results 321 to 330 of about 4,190,416 (396)

Enhancing Osteogenesis through Bio‐Inspired Recombinant Coral Protein Galaxin by Targeting Mitochondrial Metabolism and ATP Production

Advanced Science, Volume 12, Issue 17, May 8, 2025.
The study highlights the potential of recombinant galaxin (a coral protein) as a novel and effective biomaterial for bone regeneration. It binds to ATP synthase subunit β (ATP5B) in mouse pre‐osteoblasts, thereby causing increased ATP production and mitochondrial activity.
Fei Yu, Xing Zhao, Ting Jiang, Ningjuan Ouyang, Peilin Li, Wei Yang, Zhihe Zhao   +6 more
wiley   +1 more source

Combining RNA-seq, molecular docking and experimental verification to explore the mechanism of BAM15 as a potential drug for atherosclerosis. [PDF]

Sci Rep
Ma M, Zhong J, Tai Y, Xu S, Pei Z, Wang X.   +5 more
europepmc   +1 more source

Targeting Histone Deacetylase 11 with a Highly Selective Inhibitor for the Treatment of MASLD

Advanced Science, Volume 12, Issue 15, April 17, 2025.
A potent HDAC11‐specific inhibitor, B6, is identified using substrate‐mimic and bioisosteric replacement strategies. B6 demonstrates high oral bioavailability, extensive liver distribution, and a favorable safety profile. B6 effectively alleviates metabolic dysfunction‐associated steatotic liver disease by increasing the expression of LKB1 and ...
Feng Zhang, Kairui Yue, Simin Sun, Shengyuan Lu, Geng Jia, Yang Zha, Shuang Zhang, C. James Chou, Chenzhong Liao, Xiaoyang Li, Yajun Duan   +10 more
wiley   +1 more source

The Effects of Polyphenols on Texture and Flavor of Egg Yolk: A Molecular Docking Study. [PDF]

Foods
Tang T, Zhang R, Chang C, Li J, Gu L, Yang Y, Su Y.   +6 more
europepmc   +1 more source

CPL‐Diff: A Diffusion Model for De Novo Design of Functional Peptide Sequences with Fixed Length

Advanced Science, EarlyView.
This study presents a diffusion model for generating functional peptide sequence lengths using mask control. The model can generate antimicrobial, antifungal, and antiviral peptides with specific lengths on demand. The model learns the structure of peptides better and generates peptides with better physicochemical properties, and the model has good ...
Zhenjie Luo, Aoyun Geng, Leyi Wei, Quan Zou, Feifei Cui, Zilong Zhang   +5 more
wiley   +1 more source

Characterization of lncRNA-protein interactions associated with Prostate cancer and Androgen receptors by molecular docking simulations. [PDF]

Biochem Biophys Rep
Khilwani B, Kour B, Shukla N, Vuree S, Ansari AS, Lohiya NK, Suravajhala P, Suravajhala R.   +7 more
europepmc   +1 more source

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

Advanced Science, EarlyView.
As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang, Qixia Xu, Zhirui Jiang, Rong Sun, Qun Wang, Sanhong Liu, Xin Luan, Judith Campisi, James L. Kirkland, Weidong Zhang, Yu Sun   +10 more
wiley   +1 more source

Discovery of novel DdlA inhibitors in multidrug-resistant Pseudomonas aeruginosa using virtual screening, molecular docking, and dynamics simulations. [PDF]

Sci Rep
Aldakheel FM, Alduraywish SA.
europepmc   +1 more source

Icaritin Represses Autophagy to Promote Colorectal Cancer Cell Apoptosis and Sensitized Low‐Temperature Photothermal Therapy via Targeting HSP90‐TXNDC9 Interactions

Advanced Science, EarlyView.
Icaritin demonstrates broad antitumor effects by inhibiting colorectal cancer (CRC) cell proliferation, migration, invasion, and causing cell cycle arrest. It induces apoptosis by repressing autophagic flux through disrupting HSP90‐TXNDC9 interactions.
Dan He, Siliang Chen, Xiaoyun Wang, Xiang Wen, Changyang Gong, Lei Liu, Gu He   +6 more
wiley   +1 more source

Identification and Exploration of Immunity-Related Genes and Natural Products for Alzheimer's Disease Based on Bioinformatics, Molecular Docking, and Molecular Dynamics. [PDF]

Immun Inflamm Dis
Liang P, Wang Y, Liu J, Huang H, Li Y, Kang J, Li G, Wu H.   +7 more
europepmc   +1 more source