Results 341 to 350 of about 4,190,416 (396)

Green synthesis, characterization, in silico molecular docking and biological evaluation of imidazolylchalcones as promising fungicide/s and nematicide/s. [PDF]

BMC Chem
Kumar R, Kaushik P, Tripathi K, Godara R, Misra SR, Kumar V, Mondal PC, Jeetram, Pankaj, Rana VS, Shanmugam V, Khatri D, Shakil NA.   +12 more
europepmc   +1 more source

Functional Characterization of an Aldol Condensation Synthase PheG for the Formation of Hispidin from Phellinus Igniarius

Advanced Science, Volume 12, Issue 11, March 20, 2025.
Hispidin is a polyphenolic compound with a variety of biological activities. Herein, a new aldol condensase PheG from Phellinus igniarius (P. igniarius) can catalyze tricetolatone and 3, 4‐dihydroxybenzaldehyde to hispidin. The catalytic mechanism of nucleophilic addition of PheG is determined by MM/GBSA, density functional theory calculation, and site‐
Wanting Zhang, Ruliang Zheng, Weiling Geng, Xinyuan Wu, Xiaojuan Gao, Li Zhou, Zhenyu An, Cheng Liu, Zhijun Song, Hongyan Ji, Hao Yang, Xiuli Wu   +11 more
wiley   +1 more source

Molecular mechanism of the effect of BixiezelanYin on knee osteoarthritis based on network pharmacology and molecular docking. [PDF]

Medicine (Baltimore)
Huang R, Lu J, Yang X, Sheng G, Qin F, Yang X.   +5 more
europepmc   +1 more source

Customization of Ethylene Glycol (EG)‐Induced BmoR‐Based Biosensor for the Directed Evolution of PET Degrading Enzymes

Advanced Science, Volume 12, Issue 13, April 3, 2025.
PET degrading enzymes are evolved employing a novel fluorescence high‐throughput screening tool via a performance‐improved ethylene glycol (EG)‐induced BmoR‐based biosensor modified by TF engineering. PET waste is completely depolymerized into its basic units at moderate temperatures.
Min Li, Zhenya Chen, Wuyuan Zhang, Tong Wu, Qingsheng Qi, Yi‐Xin Huo   +5 more
wiley   +1 more source

SMILES-based QSAR and molecular docking studies of chalcone analogues as potential anti-colon cancer. [PDF]

Sci Rep
Askarzade A, Ahmadi S, Almasirad A.
europepmc   +1 more source

α‐Lipoic Acid Ameliorates Arsenic‐Induced Lipid Disorders by Promoting Peroxisomal β‐Oxidation and Reducing Lipophagy in Chicken Hepatocyte

Advanced Science, Volume 12, Issue 11, March 20, 2025.
Arsenic‐induced liver injury poses a serious threat to human health and poultry industry. This study finds that α‐lipoic acid alleviates arsenic‐induced lipid accumulation and enhances lipophagy by targeting SIRT1, ameliorating mitochondrial damage, enhancing peroxisomal β‐oxidation.
Yangfei Zhao, Mingyue Guo, Ting Pei, Chenqi Shang, Yirong Chen, Liying Zhao, Yiguang Lu, Chen Liang, Jundong Wang, Jianhai Zhang   +9 more
wiley   +1 more source

Exploring the anticancer potential of Hewittia malabarica through phytochemical analysis and molecular docking study. [PDF]

Sci Rep
Thozhukkad Moosaripparambil S, Vadakkadath Meethal K.   +1 more
europepmc   +1 more source

Targeting the E Prostanoid Receptor EP4 Mitigates Cardiac Fibrosis Induced by β‐Adrenergic Activation

Advanced Science, Volume 12, Issue 12, March 27, 2025.
This study explores the roles of cardiomyocyte‐ and cardiac fibroblast‐specific EP4 in isoproterenol‐induced cardiac fibrosis. The findings reveal that EP4 inhibition improves diastolic function and reduces fibrosis by modulating TGF‐β1 signaling and extracellular matrix protein production.
Hu Xu, Xiuhui Mao, Yali Wang, Chunhua Zhu, Bo Liang, Yihang Zhao, Mengfei Zhou, Lan Ye, Mengting Hong, Huishu Shao, Yashuo Wang, Haonan Li, Yinghui Qi, Yongliang Yang, Lihong Chen, Youfei Guan, Xiaoyan Zhang   +16 more
wiley   +1 more source

Virtual screening combined with molecular docking for the !identification of new anti-adipogenic compounds. [PDF]

Sci Prog
Mandujano-Lázaro G, Torres-Rojas MF, Ramírez-Moreno E, Marchat LA.   +3 more
europepmc   +1 more source

A Hf(IV)‐Coordinated NIR‐II Fluorescence “Turn‐On” Nanoprobe for Precise Imaging‐Guided Surgery in Breast Cancer

Advanced Science, Volume 12, Issue 14, April 10, 2025.
Based on the FDA‐approved fluorescent dye ICG, a Hf(IV)‐coordinated NIR‐II fluorescence “turn‐on” nanoprobe is constructed. This ultrasensitive nanoprobe can effectively accumulate in tumor sites and recover the fluorescence of ICG specifically in tumor microenvironment, accurately identifying submillimeter‐sized tumors with high sensitivity for real ...
Yueyang He, Jinyan Lin, Jingwen Bai, Xiao Shen, Kangliang Lou, Yuanyuan Zhu, Zishan Qiao, Weiling Chen, Yang Li, Xiaolong Liu, Guojun Zhang   +10 more
wiley   +1 more source