Results 231 to 240 of about 109,425 (326)

Quantitative Analysis and Molecular Docking Simulation of Flavonols from Eruca sativa Mill. and Their Effect on Skin Barrier Function. [PDF]

Curr Issues Mol Biol
Park J, Choi W, Kim J, Kim HW, Lee JY, Lee J, Kim B.   +6 more
europepmc   +1 more source

Molecular docking and dynamic simulation studies against the ERα of breast cancer using biomolecules from Asparagus aethiopicus L.

Aman Agrawal, Deepti Teotia, Vivek Kumar, Pooja Jain, Agrawal Bhanu, Kumar Ashish, Yeshvandra Verma, Vijai Malik   +7 more
openalex   +2 more sources

TOPK Inhibition Promotes Anti‐Tumor Immunity Via eIF4F Complex Mediated STAT1 Translation in Gastric Cancer

Advanced Science, EarlyView.
This study identifies TOPK as a dual‐function target in gastric cancer: it drives tumor cell proliferation and migration, and under IFN‐γ stimulation, phosphorylates eIF4F complex component eIF4A1 to enhance STAT1 mRNA translation, thereby promoting PD‐L1/IDO1‐mediated tumor immunometabolic evasion.
Junbing Chen, Longtao Huangfu, Gangjian Wang, Xueying Wang, Huanbo Zhu, Qian Yao, Cong Chen, Xiaohuan Tang, Ting Guo, Biao Fan, Xingyang Liu, Qingda Li, Zining Liu, Ying Hu, Tianze Sun, Jiafu Ji, Xiaofang Xing   +16 more
wiley   +1 more source

Additional file 3 of Two cases of TBL1XR1 heterozygous variants in children: a new splicing site variant identification and functional analysis through molecular docking and molecular dynamics simulation

Yaxue Xie, Z. Y. Zhang, Gang Zhu, Zhichao Li, Huiling Zhang, Jiaqi Zhang, Lin Wan, Guang Yang   +7 more
openalex   +1 more source

A Reactive Antagonist Strategy: Cysteine‐Directed Covalent Molecular Glue in Plant Hormone Receptor Regulation

Advanced Science, EarlyView.
The plant hormone jasmonate is perceived by COI1‐JAZ co‐receptors comprising a single F‐box protein COI1 and multiple JAZ repressors with overlapping functions, complicating genetic analysis. We present a reactive antagonist (RA) strategy that selectively promotes COI1 binding to a cysteine‐engineered JAZ variant while blocking wild‐type JAZs, enabling
Minoru Ueda, Kotaro Matsumoto, Takao Nomura, Yousuke Takaoka, Taichi Okumura, Wataru Kozaki, Hikaru Hoshikawa, Yuho Nishizato, Andrea Chini, Roberto Solano, Katsumi Maenaka   +10 more
wiley   +1 more source

Comprehensive analysis of bioactive compounds in Crocus sativus stamens extracts by HPLC-DAD: investigating antidiabetic activity via in vitro, in vivo, and molecular docking simulation. [PDF]

Front Chem
Mamri S, Daoudi NE, Baraich A, Ouahhoud S, Khoulati A, Choukri M, Asehraou A, Bnouham M, Jaouadi B, Abousalham A, Dabiellil F, Salamatullah AM, Saalaoui E.   +12 more
europepmc   +1 more source

Anti-aging Effects of Mangosteen Peel Extract and Its Phytochemical Compounds: Antioxidant Activity, Enzyme Inhibition and Molecular Docking Simulation. [PDF]

Trop Life Sci Res, 2020
Widowati W, Ginting CN, Lister INE, Girsang E, Amalia A, Wibowo SHB, Kusuma HSW, Rizal.   +7 more
europepmc   +1 more source

Rescuing Mitochondrial Dysfunction in Macrophages Prevents Osteonecrosis of the Jaw in Anti‐Resorptive Therapy

Advanced Science, EarlyView.
Schematic model showing the suggested mechanism that ZA induces classical activation of macrophages by impairing mitochondrial biofunction and inhibiting mitochondrial clearance to contribute to the pathological process of BRONJ. RAPA‐loaded nanoparticles ZDPR has shown potential in alleviating BRONJ lesions as well as treating osteoporosis or ...
Hang Zhang, Xin Shen, Haiyang Liu, Xinxi Yuan, Mumin Cao, Xuepeng Lv, Ziji Ling, Songsong Guo, Rongyao Xu, Xiang Li, Hongbing Jiang   +10 more
wiley   +1 more source

Role of IRE1α/XBP1/CHOP/NLRP3 Signalling Pathway in Neonicotinoid Imidacloprid-Induced Pancreatic Dysfunction in Rats and Antagonism of Lycopene: In Vivo and Molecular Docking Simulation Approaches. [PDF]

Toxics
El Gazzar WB, Bayoumi H, Youssef HS, Ibrahim TA, Abdelfatah RM, Gamil NM, Iskandar MK, Abdel-Kareim AM, Abdelrahman SM, Gebba MA, Mohamed MA, Mokhtar MM, Kharboush TG, Bayoumy NM, Alomar HA, Farag AA.   +15 more
europepmc   +1 more source

Structure‐Guided Engineering of a Promiscuous O‐Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals

Advanced Science, EarlyView.
A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong, Jun Song, Shihan Li, Lu Jin, Qi He, Baohui Zhang, Yan Cao, Shanyong Yi, Yanfang Yang, Xiang Li, Juan Li, Wei Huang   +11 more
wiley   +1 more source