Results 261 to 270 of about 449,170 (361)

SenExo‐cCCT2 Reprograms Senescence Response and Anti‐Tumor Immunity Following FOLFIRINOX Chemotherapy in Pancreatic Ductal Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
This study demonstrates that SenExo‐cCCT2 enables targeted delivery of cCCT2 to pancreatic cancer cells, where it disrupts IPO13‐mediated nuclear translocation of UBC9, impairing SUMOylation‐dependent DNA damage repair and inducing senescence. Senescent tumor cells secrete CXCL10 to recruit CD8⁺ T‐cells while upregulating PD‐L1.
Shuncang Zhu   +18 more
wiley   +1 more source

Comprehensive analysis of bioactive compounds in Crocus sativus stamens extracts by HPLC-DAD: investigating antidiabetic activity via in vitro, in vivo, and molecular docking simulation. [PDF]

open access: yesFront Chem
Mamri S   +12 more
europepmc   +1 more source

Regulating Enzyme Activity via Microaggregates Mediated by Phase Separation

open access: yesAdvanced Science, EarlyView.
An enzyme‐sequestration strategy for combating postoperative pancreatic fistula (POPF) is developed, employing a D‐peptide called DPMD to induce liquid–solid phase separation (LSPS) of pancreatic proteases. This LSPS‐driven microaggregate approach effectively isolates trypsin and chymotrypsin from their substrates, thereby reducing pancreatic fluid ...
Yang Wang   +7 more
wiley   +1 more source

Anti-aging Effects of Mangosteen Peel Extract and Its Phytochemical Compounds: Antioxidant Activity, Enzyme Inhibition and Molecular Docking Simulation. [PDF]

open access: yesTrop Life Sci Res, 2020
Widowati W   +7 more
europepmc   +1 more source

Biomolecular Interaction Prediction: The Era of AI

open access: yesAdvanced Science, EarlyView.
This review offers a thorough examination of recent progress in deep learning for predicting biomolecular interactions, including those involving proteins, nucleic acids, and small molecules. It covers data processing strategies, representative model architectures, and evaluation metrics, while highlighting current methodological limitations.
Haoping Wang, Xiangjie Meng, Yang Zhang
wiley   +1 more source

Role of IRE1α/XBP1/CHOP/NLRP3 Signalling Pathway in Neonicotinoid Imidacloprid-Induced Pancreatic Dysfunction in Rats and Antagonism of Lycopene: In Vivo and Molecular Docking Simulation Approaches. [PDF]

open access: yesToxics
El Gazzar WB   +15 more
europepmc   +1 more source

Aptamer‐Mediated Artificial Synapses for Neuromorphic Modulation of Inflammatory Signaling via Organic Electrochemical Transistor

open access: yesAdvanced Science, EarlyView.
An aptamer‐mediated neuromorphic interface based on organic electrochemical transistors selectively transduces interleukin‐6 (IL‐6) signals into neuromorphic electrical outputs. This protein‐driven neuromorphic plasticity, responsive in physiological and in vivo environmental electrolyte, bridges biochemical signaling with artificial neural encoding ...
Yuqing Ding   +11 more
wiley   +1 more source

Globotriaosylceramide Gb3 Influences Wound Healing and Scar Formation by Orchestrating Fibroblast Heterogeneity

open access: yesAdvanced Science, EarlyView.
In superficial second‐degree burn wounds, Gb3 turns on genes related to papillary cells through the FGF2 signaling pathway. This increases the ability of cells to break down fibrin and decreases fibrosis, which ultimately prevents scar formation in burn injuries.
Sujie Xie   +13 more
wiley   +1 more source

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