Results 271 to 280 of about 449,170 (361)

Innovation of 6-sulfonamide-2H-chromene derivatives as antidiabetic agents targeting α-amylase, α-glycosidase, and PPAR-γ inhibitors with in silico molecular docking simulation. [PDF]

RSC Adv
Thabet HK, Ragab A, Imran M, Hamdy Helal M, Ibrahim Alaqel S, Alshehri A, Ash Mohd A, Alshammari SS, Ammar YA, Abusaif MS.   +9 more
europepmc   +1 more source

Tailoring Regioselectivity‐Controlled UDP‐Glycosyltransferase for Bidirectional Glycosylation of Tyrosol via Free Energy‐Driven Pocket Reshaping and Tunnel Engineering

Advanced Science, EarlyView.
To address inherent limitations in regioselectivity and catalytic efficiency of UDP‐glycosyltransferases, an integrated strategy combining free‐energy driven pocket reshaping and tunnel engineering is developed. This strategy enables UGTBL1 to bidirectional glycosylation of tyrosol, synthesizing salidroside or icariside D2 without extensive screening ...
Ziyu Zhang, Jingyi Chen, Zuozhi Liang, Wenming Shao, Zhen Gao, Bin Wu, Bingfang He, Gerhard Schenk   +7 more
wiley   +1 more source

Designing of phenol-based β−carbonic anhydrase1 inhibitors through QSAR, molecular docking, and MD simulation approach

, 2018
Shahzaib Ahamad, Md. Imtaiyaz Hassan, Neeraja Dwivedi   +2 more
openalex   +1 more source

Hologenomics Reveals Specialized Dietary Adaptations in the Mengla Snail‐Eating Snake

Advanced Science, EarlyView.
Dietary adaptation studies from a holobiome perspective are scarce beyond mammals. This research reveals how genomic and microbial interactions drive dietary specialization in the Mengla snail‐eating snake, with evidence of gut symbiont convergence between reptiles and mammals.
Chaochao Yan, Xin‐Ning Li, Zhong‐Liang Peng, Wei Wu, Zeng Wang, Zhao‐Ran Zhu, Jia‐Chang Liu, Yao Wang, Jin‐Long Ren, Zhi‐Yi Zhang, Jia‐Tang Li   +10 more
wiley   +1 more source

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation. [PDF]

RSC Adv, 2020
Bui TQ, Phuong Loan HT, Ai My TT, Quang DT, Phuong Thuy BT, Nhan VD, Quy PT, Van Tat P, Dao DQ, Trung NT, Huynh LK, Ai Nhung NT.   +11 more
europepmc   +1 more source

Lactate Dehydrogenase C4 Accelerates Triple‐Negative Breast Cancer Progression by Promoting Acetyl‐CoA Acyltransferase 2 Lactylation to Increase Free Fatty Acid Accumulation

Advanced Science, EarlyView.
Diagram of the reprogramming of FA metabolism mediated by LDHC4‐induced ACAA2 activity to promote TNBC progression. LDHC4 drives TNBC progression by enhancing ACAA2‐mediated fatty acid production. The resulting accumulation of FFAs stimulates autophagy and accelerates cell cycle progression, thereby promoting tumor growth.
Zhaolei Cui, Chaoqiang Zheng, Yingying Lin, Zhenzhou Xiao, Yanhong Li, Wei Peng, Shijie He, Anyang Li, Xiufeng Wu, Yan Chen, Yang Sun   +10 more
wiley   +1 more source

Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives

Aggregate, EarlyView.
Triterpenoids serve as both exceptional molecular motifs for supramolecular assembly and versatile therapeutic agents, offering broad biological functions to improve health outcomes and enhance treatment efficacy. This review comprehensively summarizes recent advances in triterpenoid‐based supramolecular systems, including their roles as functional ...
Jie Zhong, Juan C. Mareque‐Rivas, Xinmiao Lan, Yu‐Xiong Su   +3 more
wiley   +1 more source

Conformational analysis, spectroscopic (FTIR, NMR and UV-Vis.), molecular docking and quantum chemical simulation studies of 1-phenylethanone-O-pyropyl oxime ether

, 2018
Ilhan Kucuk, Yunus Kaya
openalex   +1 more source

Twinkle Light‐Inspired Aggregation‐Induced Emission “Lighting‐Up” Bacteriophages to Enhance Immunoassays via Spontaneous Amino‐Yne Click Reaction

Aggregate, EarlyView.
Herein, we present a twinkle‐light‐inspired “lighting‐up” bifunctional bacteriophage for fluorescence immunoassays via a spontaneous amino‐yne click reaction, and demonstrate its versatile potential for the highly sensitive detection of various targets, ranging from small molecules to pathogenic microorganisms, in complex samples.
Xiaoyi Lv, Xirui Chen, Qi Chen, Qing Liu, Mingjian Yao, Weipeng Tong, Hao Fang, Yiping Chen, Yonghua Xiong, Ben Zhong Tang, Xiaolin Huang   +10 more
wiley   +1 more source