Results 271 to 280 of about 109,425 (326)

Synthesis, Antimicrobial Evaluation, Molecular Docking and Dynamics Simulations of Novel 2,3‐Disubstituted Quinazolin‐4(3 H )‐one Derivatives [PDF]

Priyanka Verma, Lai Zhen Xiang, Udit Chaube, Gopal Natesan   +3 more
openalex   +1 more source

Bridging Green Chemistry and Circular Economy: A Pathway to Sustainable Polyester Plastics Through Feedstock, Synthesis, and Waste Upcycling

Advanced Science, EarlyView.
This review summarizes green and low‐carbon strategies throughout the entire life cycle of polyester plastics, including sustainable monomer synthesis, optimization polymerization, efficient recycling, and advanced upcycling technologies. The synergistic implementation of these strategies is expected to significantly promote the development of a ...
Jinzhou Li, Junliang Chen, Yingbing Zhang, Li Wang, Pin Gao, Jianping Yang   +5 more
wiley   +1 more source

Domino Multicomponent Approach for the Synthesis of Functionalized Spiro-Indeno[1,2-b]quinoxaline Heterocyclic Hybrids and Their Antimicrobial Activity, Synergistic Effect and Molecular Docking Simulation. [PDF]

Molecules, 2019
Almansour AI, Arumugam N, Suresh Kumar R, Al-Thamili DM, Periyasami G, Ponmurugan K, Al-Dhabi NA, Perumal K, Premnath D.   +8 more
europepmc   +1 more source

Integrative in-silico analysis on phytocompounds of Pajanelia longifolia against hepatocellular carcinoma: gene network target identification, molecular docking, simulation and ADMET profiling [PDF]

Tapan K. Das, Shuvasish Choudhury, Manabendra Dutta Choudhury   +2 more
openalex   +1 more source

A Murine Database of Structural Variants Identifies A Candidate Gene for a Spontaneous Murine Lymphoma Model

Advanced Science, EarlyView.
We analyzed long‐read genomic sequencing data obtained from 40 inbred mouse strains to produce a large database of structural variants. This dataset captures the major types of structural variants, which includes deletions, insertions, duplications, and inversions.
Wenlong Ren, Zhuoqing Fang, Egor Dolzhenko, Christopher T. Saunders, Zhuanfen Cheng, Victoria Popic, Gary Peltz   +6 more
wiley   +1 more source

Molecular Docking and Molecular Dynamics Simulation for Oxindole and 1,2,3-Triazole Tethered Derivatives for Anti-Tubercular Activity

Sundarrajan Thirugnanasambandam, NAVEEN KUMAR R   +1 more
openalex   +1 more source

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
wiley   +1 more source

Network Pharmacology-Guided Discovery and Computational Validation of Pinocembrin-Based Anticancer Inhibitors Targeting MMP9, TP53, and HIF1α through Molecular Docking, ADMET Profiling, and Molecular Dynamics Simulations

Md Reaz Uddin, Golam Mohiuddin, Abu Sadat Muhammod Saiyem, Ishraq Murshed, Monotosh Sarkar, Asit Baron Sarker, Tamanna Rashid, Ray Sobuj, Shibam Mondal, Md Shafiqul Islam Sovon, Mahbubur Rahman, Fahima Aktar, Md. Shah Amran   +12 more
openalex   +1 more source

Novel Hexahydroacridine‐1,8‐diones as Cholinesterase Inhibitors: Design, Synthesis, Molecular Docking, and Molecular Dynamics Simulation [PDF]

Zahra Najafi, Ahmad Mataji‐Nimvar, Asrin Bahmani, Gholamabbas Chehardoli, Aida Iraji   +4 more
openalex   +1 more source

Lactylation Reprogramming in the Bone Infection Microenvironment Identifies PGK1 K361 as a Potential Therapeutic Target for Osteogenic Dysfunction

Advanced Science, EarlyView.
Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin, Si‐ying He, Ting‐hui Xiao, Da‐mao Dai, Xin‐jia Hu, Nan Jiang   +5 more
wiley   +1 more source