Results 291 to 300 of about 449,170 (361)

A hepatoprotective experiment on taro vegetable (Colocasia esculenta (L.) Schott) flower employing animal models by mitigating oxidative stress

Animal Models and Experimental Medicine, EarlyView.
The antioxidant efficacy of Colocasia esculenta flower’s methanolic extract was assessed using 2,2′‐azino‐bis‐(3‐ethylbenzothiazoline‐6‐sulfonic) (ABTS) and 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) scavenging assay. The hepatoprotective effect was investigated by assessing liver injury indicators (amino transferase [ALT], aspartate amino transferase [AST],
Mahathir Mohammad, Fahmida Tasnim Richi, Rabiul Hossain, Md. Arafat, Pair Ahmed Jiko, Nazim Uddin Emon, Sayed Al Hossain Rabbi, Tirtha Khastagir, Md. Hemayet Hossain, Safaet Alam   +9 more
wiley   +1 more source

Photosensitizer Repositioning Affords an Enantiocomplementary Enzyme for [2 + 2]‐Cycloadditions

Angewandte Chemie, EarlyView.
In this study, we capitalize on the versatility offered by genetic code expansion to develop a proficient photoenzyme for [2 + 2]‐cycloadditions that is enantiocomplementary to our recently developed photoenzyme EnT1.3. By repositioning the genetically programmed benzophenone photosensitizer and subsequent directed evolution, we have developed an ...
Chuanjie Sun, Anna R. Kohn, Ross Smithson, Florence J. Hardy, Jonathan S. Trimble, Yuanxin Cao, Linus O. Johannissen, Sam Hay, Rebecca Crawshaw, Anthony P. Green   +9 more
wiley   +2 more sources

QSAR analysis and molecular docking simulation of norepinephrine transporter (NET) inhibitors as anti-psychotic therapeutic agents. [PDF]

Heliyon, 2019
Olasupo SB, Uzairu A, Shallangwa G, Uba S.   +3 more
europepmc   +1 more source

Cistanche tubulosa improves peripheral neuropathy in MPTP‐induced PD mice based on regulation of m6A methylation

Animal Models and Experimental Medicine, EarlyView.
At steady state, DRG ensures low‐level expression of TH+ neurons under the protection of AKT. However, the DRG level of PD mouse model under MPTP toxicity increased significantly, and the expression of IL‐6 and CASP3 increased. This process was accompanied by the occurrence of m6A demethylation, with a significant increase in FTO as the main ...
Yatan Li, Wei Jia, Junhua Hu, Borui Zhang, Xinxin Qi, Jianhua Yang, Xinling Yang   +6 more
wiley   +1 more source

Harnessing the multidimensional bioactivity of Chaetomorpha aerea: Integrative phytochemical profiling with in vitro, in vivo, and in silico insights

Animal Models and Experimental Medicine, EarlyView.
This study revealed the antioxidant, anti‐inflammatory, and antidiabetic potentials of the seaweed Chaetomortpha aerea using in vitro, in vivo, and in silico approaches along with phytochemical analysis using gas chromatography–mass spectrometry. ADME/T analysis was also carried out to confirm drug likeness and toxicity prediction.
Md. Mahmudul Hasan, Md. Abdul Alim, Md. Safayat Hossen Momen, Md. Shahidul Islam, Sajjad Hossen Chowdhury, Mohammad Rashed, Fahmina Hoque, S. M. Moazzem Hossen   +7 more
wiley   +1 more source

Thermodynamics of Water Displacement from Binding Sites and its Contributions to Supramolecular and Biomolecular Affinity

Angewandte Chemie, EarlyView.
The affinity between a guest and a macrocyclic host depends strongly on the water encapsulated inside the host cavity, with free‐energy variations on the order of 20 kcal mol−1 being possible even in the absence of direct host‐guest interactions. This conclusion–which contrasts alternative views–can be drawn from molecular dynamics simulations for the ...
Jeffry Setiadi, Frank Biedermann, Werner M. Nau, Michael K. Gilson   +3 more
wiley   +2 more sources

Interaction of N-3-oxododecanoyl homoserine lactone with transcriptional regulator LasR of Pseudomonas aeruginosa: Insights from molecular docking and dynamics simulations

, 2019
Hovakim Grabski, Lernik Hunanyan, Susanna Tiratsuyan, Hrachik Vardapetyan   +3 more
openalex   +2 more sources

Structural Basis for a Scaffolding Role of the COM Domain in Nonribosomal Peptide Synthetases

Angewandte Chemie, EarlyView.
COM domains are known as docking domains between subunits of nonribosomal peptide synthetases (NRPSs). Here, the first structure of a fused, internal COM domain with its neighboring domains is reported. Structural, biochemical and crosslinking data show that COM domains play an unexpected role in properly positioning epimerization (E) and condensation (
Julia Diecker, Benedikt Hermanns, Jennifer Rüschenbaum, René Rasche, Wolfgang Dörner, Alexander Schröder, Daniel Kümmel, Henning D. Mootz   +7 more
wiley   +2 more sources

Pharmacophore modeling, molecular docking and molecular dynamics simulation for screening and identifying anti-dengue phytocompounds

, 2019
Jaykant Vora, Shivani Patel, Mohd Athar, Sonam Sinha, Mahesh T. Chhabria, Prakash C. Jha, Neeta Shrivastava   +6 more
openalex   +2 more sources