Results 101 to 110 of about 6,867,350 (304)
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Molecular Dynamics of the Association of L-Selectin and FERM Regulated by PIP2 [PDF]
, 2018 Phosphatidylinositol 4,5-bisphosphate (PIP2) acts as a signaling lipid, mediating membrane trafficking and recruitment of proteins to membranes. A key example is the PIP2-dependent regulation of the adhesion of L-selectin to the cytoskeleton adaptors of ...
Luo, Shi-Zhong +12 more
core +2 more sources
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Nature Communications, 2017 Optical imaging deep in biological tissue is difficult due to multiple scattering and specimen induced aberrations of both the incident and reflected light. Here, Kang et al.
Sungsam Kang +12 more
doaj +1 more source
Nature Communications, 2020 Sulfur is abundant in the Universe, but the observed abundance ratio of SH to H2S doesn’t agree with astrochemical models. The authors measure product state-resolved translational energy spectra of photoproducts in a jet-cooled H2S beam as a function of ...
Jiami Zhou +17 more
doaj +1 more source
Classical molecular dynamics [PDF]
The Journal of Chemical Physics, 2021 Charles L. Brooks +5 more
openaire +2 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Current Opinion in Structural BiologyUnderstanding biomolecular function depends on bridging experimental observables with models that capture structural, stationary, and dynamical properties. Molecular dynamics (MD) simulations, in principle provide a bridge, but the sampling problem remains a fundamental roadblock toward this goal.
openaire +2 more sources
A Multiscalling Constant Lambda Molecular Dynamic Gromacs Implementation [PDF]
, 2009 Molecular dynamics is one of the methods used now-a-days by the scientific community to study the property of polymers. This paper presents a new method for multiscaling molecular dynamics that combines the advantages of fine-grained and coarse grained ...
Marrink, Siewert; id_orcid +3 more
core +1 more source