Results 31 to 40 of about 66,004 (258)

A molecular mechanism for proton‐dependent gating in KcsA [PDF]

FEBS Letters, 2010
Activation gating in KcsA is elicited by changes in intracellular proton concentration. Thompson et al.[1] identified a charge cluster around the inner gate that plays a key role in defining proton activation in KcsA. Here, through functional and spectroscopic approaches, we confirmed the role of this charge cluster and now provide a mechanism of pH ...
Cuello, Luis G., Cortes, D. Marien, Jogini, Vishwanath, Sompornpisut, Amornrat, Perozo, Eduardo   +4 more
openaire   +2 more sources

Fluorescence-Based Multimodal DNA Logic Gates

Nanomaterials
The use of DNA structures in creating multimodal logic gates bears high potential for building molecular devices and computation systems. However, due to the complex designs or complicated working principles, the implementation of DNA logic gates within ...
Chamika Harshani Algama, Jamil Basir, Kalani M. Wijesinghe, Soma Dhakal   +3 more
doaj   +1 more source

Radiative Corrections and Quantum Gates in Molecular Systems [PDF]

Physical Review Letters, 2004
We propose a method for quantum information processing using molecules coupled to an external laser field. This utilizes molecular interactions, control of the external field and an effective energy shift of the doubly-excited state of two coupled molecules.
Reina, John H., Beausoleil, Ray G., Spiller, Tim P., Munro, William J.   +3 more
openaire   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Gated Nanosensor for Sulphate-Reducing Bacteria Detection

Nanomaterials
Desulfovibrio vulgaris is an anaerobic microorganism belonging to the group of sulphate-reducing bacteria (SRB). SRB form biofilms on metal surfaces in water supply networks, producing a microbiologically influenced corrosion (MIC). This process produces
Alba López-Palacios, Ángela Morellá-Aucejo, Yolanda Moreno, Román Ponz-Carcelén, María Pedro-Monzonís, M. Dolores Marcos, Andrea Bernardos, Félix Sancenón, Elena Aznar, Ramón Martínez-Máñez, Andy Hernández-Montoto   +10 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A Fluorogenic Biosensor for Direct Detection of Vibrio vulnificus, a Climate Change Biomarker

MicrobiologyOpen
Vibrio vulnificus, a marine pathogen and climate change biomarker, poses serious risks to human and animal health through seafood consumption and seawater exposure. Rapid detection methods are urgently needed for both vibriosis diagnosis and surveillance
M. Nieves Aranda, Isabel Caballos, Alba López‐Palacios, Héctor Carmona‐Salido, Eva Sanjuan, Elena Aznar, Carmen Amaro, Ramón Martínez‐Máñez, Andy Hernández‐Montoto   +8 more
doaj   +1 more source

A modular design of molecular qubits to implement universal quantum gates

Nature Communications, 2016
The physical implementation of quantum information processing requires individual qubits and entangling gates. Here, the authors demonstrate a modular implementation through chemistry, assembling molecular {Cr7Ni} rings acting as qubits, with ...
Jesús Ferrando-Soria, Eufemio Moreno Pineda, Alessandro Chiesa, Antonio Fernandez, Samantha A. Magee, Stefano Carretta, Paolo Santini, Iñigo J. Vitorica-Yrezabal, Floriana Tuna, Grigore A. Timco, Eric J.L. McInnes, Richard E.P. Winpenny   +11 more
doaj   +1 more source

Tracing a new path in the field of AI and robotics: mimicking human intelligence through chemistry. Part I: molecular and supramolecular chemistry

Frontiers in Robotics and AI, 2023
Chemical Artificial Intelligence (CAI) is a brand-new research line that exploits molecular, supramolecular, and systems chemistry in wetware (i.e., in fluid solutions) to imitate some performances of human intelligence and promote unconventional ...
Pier Luigi Gentili, Pasquale Stano
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source