Results 51 to 60 of about 3,395,940 (292)
A novel bio-sensor based on DNA strand displacement. [PDF]
PLoS ONE, 2014 DNA strand displacement technology performs well in sensing and programming DNA segments. In this work, we construct DNA molecular systems based on DNA strand displacement performing computation of logic gates.
Xiaolong Shi +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Gates Notice of Adopted Amendment (2007-02-01)
, 2007 11 pp. Adopted 2007-02-01. Department of Land Conservation and Development Notice of Adopted AmendmentThis amendment revised Section 15.020(L) of the Gates Zoning Ordinance, which previously allowed domestic farm animals on lots two (2) acres in size or ...
Gates
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Azo-azomethine colorimetric chemosensors as molecular logic gates
HeliyonThe use of organic molecules as logic gates and their ability to simulate the performance of key components in integrated circuits has been one of the most challenging research areas over the past 30 years. Consequently, the design and application of new
Hamid Khanmohammadi +1 more
doaj +1 more source
Molecular tuning of fast gating in pentameric ligand-gated ion channels [PDF]
Proceedings of the National Academy of Sciences, 2005 Neurotransmitters such as acetylcholine (ACh) and glycine mediate fast synaptic neurotransmission by activating pentameric ligand-gated ion channels (LGICs). These receptors are allosteric transmembrane proteins that rapidly convert chemical messages into electrical signals.
Grutter, Thomas +5 more
openaire +3 more sources
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Molecular prototypes for spin-based quantum logic gates [PDF]
, 2012 Trabajo presentado al Architecture & design of Molecule Logic Gates and Atom Circuits celebrado en Barcelona (España) del 12 al 13 de enero de 2012.In recent years, magnetic molecular clusters have been proposed as suitable materials for the realization ...
Luis, Fernando
core
Molecular mechanism of Mg2+-dependent gating in CorA [PDF]
Nature Communications, 2014 CorA is the major transport system responsible for Mg(2+) uptake in bacteria and can functionally substitute for its homologue Mrs2p in the yeast inner mitochondrial membrane. Although several CorA crystal structures are available, the molecular mechanism of Mg(2+) uptake remains to be established.
Dalmas, Olivier +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source