Results 51 to 60 of about 201,847 (294)
Spin qubits with electrically gated polyoxometalate molecules
, 2007 Spin qubits offer one of the most promising routes to the implementation of quantum computers. Very recent results in semiconductor quantum dots show that electrically-controlled gating schemes are particularly well-suited for the realization of a ...
A Ardavan +38 more
core +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
A comparison of the Bravyi-Kitaev and Jordan-Wigner transformations for the quantum simulation of quantum chemistry [PDF]
, 2018 The ability to perform classically intractable electronic structure calculations is often cited as one of the principal applications of quantum computing.
Andrew Tranter +9 more
core +2 more sources
Understanding the Molecular Gates of KirBac3.1 [PDF]
Biophysical Journal, 2013 Potassium currents across cell membranes are an essential part of electrical signalling in all cells. KirBac channels are prokaryotic homologs to mammalian Kir channels and superposition of the recently solved structures show that the fold and key features are almost indistinguishable. Potassium currents are proposed to be switched on and off using two
El-Ajouz, Sam +3 more
openaire +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Nature Communications, 2019 Potassium channels such as MthK are presumed to have two allosterically coupled gates, the activation gate and the selectivity filter gate, that control gating transitions. Here authors use X-ray crystallography and molecular dynamics simulations on MthK
Wojciech Kopec +2 more
doaj +1 more source
A novel bio-sensor based on DNA strand displacement. [PDF]
PLoS ONE, 2014 DNA strand displacement technology performs well in sensing and programming DNA segments. In this work, we construct DNA molecular systems based on DNA strand displacement performing computation of logic gates.
Xiaolong Shi +5 more
doaj +1 more source
The Bravyi-Kitaev transformation for quantum computation of electronic structure [PDF]
, 2012 Quantum simulation is an important application of future quantum computers with applications in quantum chemistry, condensed matter, and beyond. Quantum simulation of fermionic systems presents a specific challenge.
Jacob T. Seeley +5 more
core +3 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Quantum Computation with Diatomic Bits in Optical Lattices
, 2005 We propose a scheme for scalable and universal quantum computation using diatomic bits with conditional dipole-dipole interaction, trapped within an optical lattice.
A. M. Childs +8 more
core +1 more source