Results 61 to 70 of about 3,395,940 (292)

Gated single molecular device and logic gate design

Electronics Letters, 2017
The electron transport properties of an electrostatic gated single molecular transistor are investigated by using self‐consistent semi‐empirical method. The charge transport characteristics of the molecular device are analysed through the current‐voltage I SD −
R.M. Hariharan, C. Preferencial Kala, K. Janani, H. Bijo Joseph, S. Vivekananthan, D. John Thiruvadigal   +5 more
openaire   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Constructing clock-transition-based two-qubit gates from dimers of molecular nanomagnets

Physical Review Research, 2020
A good qubit must have a coherence time long enough for gate operations to be performed. Avoided level crossings allow for clock transitions in which coherence is enhanced by the insensitivity of the transition to fluctuations in external fields. Because
Charles A. Collett, Paolo Santini, Stefano Carretta, Jonathan R. Friedman   +3 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

A Reconfigurable, Dual-Output INHIBIT and IMPLICATION Molecular Logic Gate

Frontiers in Chemistry, 2020
Molecules that respond to input stimulations to produce detectable outputs can be exploited to mimic Boolean logic operators and reproduce basic arithmetic functions. We have designed a two-state fluorescent probe with tunable emission wavelength for the
Lavinia A. Trifoi, Gregory K. Hodgson, Nicholas P. Dogantzis, Stefania Impellizzeri   +3 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

FDA-Approved Drugs Containing Amide Functionality in the Last Five Years (2021–2025): Pharmaceutical Use, Trends and Synthetic Approaches

Medicines
The amide functional group remains a cornerstone of medicinal chemistry, serving as an indispensable scaffold in the design of modern therapeutics. This review presents an analysis of FDA-approved drugs (small molecules and peptides with MW < 1300 Da ...
Davide Benedetto Tiz
doaj   +1 more source

Ionospheric composition measurement by EISCAT using a global fit procedure [PDF]

Annales Geophysicae, 1996
The aim of this paper is to show the gain of the global fit procedure compared to the classical gate-by-gate analysis in the simultaneous determination of the temperatures and composition profiles in the lower F region.
B. Cabrit, W. Kofman
doaj   +1 more source

Molecular logic gates: the past, present and future

Chemical Society Reviews, 2018
Molecular logic gates, now with more than two decades of collective exploration, are poised for practical applications.
Sundus Erbas-Cakmak, Safacan Kolemen, Adam C. Sedgwick, Thorfinnur Gunnlaugsson, Tony D. James, Juyoung Yoon, Engin U. Akkaya   +6 more
openaire   +5 more sources

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source