Results 61 to 70 of about 69,192 (292)

Molecular tuning of fast gating in pentameric ligand-gated ion channels [PDF]

Proceedings of the National Academy of Sciences, 2005
Neurotransmitters such as acetylcholine (ACh) and glycine mediate fast synaptic neurotransmission by activating pentameric ligand-gated ion channels (LGICs). These receptors are allosteric transmembrane proteins that rapidly convert chemical messages into electrical signals.
Grutter, Thomas, Prado de Carvalho, Lia, Dufresne, Virginie, Taly, Antoine, Edelstein, S., Changeux, Jean-Pierre   +5 more
openaire   +3 more sources

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Molecular mechanism of Mg2+-dependent gating in CorA [PDF]

Nature Communications, 2014
CorA is the major transport system responsible for Mg(2+) uptake in bacteria and can functionally substitute for its homologue Mrs2p in the yeast inner mitochondrial membrane. Although several CorA crystal structures are available, the molecular mechanism of Mg(2+) uptake remains to be established.
Dalmas, Olivier, Sompornpisut, Pornthep, Bezanilla, Francisco, Perozo, Eduardo   +3 more
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

All Optical Logic Gates: A Tutorial

International Journal of Information and Communication Technology Research, 2012
In this paper we describe the performances of different kinds of all-optical logic gates reported up to now. We introduce all-optical logic gates based on semiconductor optical amplifiers such as ultrahigh speed logic gates exploiting four-wave mixing ...
Fatemeh Davoodi, Nosrat Granpayeh
doaj  

Ionospheric composition measurement by EISCAT using a global fit procedure [PDF]

Annales Geophysicae, 1996
The aim of this paper is to show the gain of the global fit procedure compared to the classical gate-by-gate analysis in the simultaneous determination of the temperatures and composition profiles in the lower F region.
B. Cabrit, W. Kofman
doaj   +1 more source

Gated single molecular device and logic gate design

Electronics Letters, 2017
The electron transport properties of an electrostatic gated single molecular transistor are investigated by using self‐consistent semi‐empirical method. The charge transport characteristics of the molecular device are analysed through the current‐voltage I SD −
R.M. Hariharan, C. Preferencial Kala, K. Janani, H. Bijo Joseph, S. Vivekananthan, D. John Thiruvadigal   +5 more
openaire   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A Reconfigurable, Dual-Output INHIBIT and IMPLICATION Molecular Logic Gate

Frontiers in Chemistry, 2020
Molecules that respond to input stimulations to produce detectable outputs can be exploited to mimic Boolean logic operators and reproduce basic arithmetic functions. We have designed a two-state fluorescent probe with tunable emission wavelength for the
Lavinia A. Trifoi, Gregory K. Hodgson, Nicholas P. Dogantzis, Stefania Impellizzeri   +3 more
doaj   +1 more source

Engineering calcium signaling of astrocytes for neural–molecular computing logic gates

Scientific Reports, 2021
This paper proposes the use of astrocytes to realize Boolean logic gates, through manipulation of the threshold of $$\hbox {Ca}^{2+}$$ Ca 2 + ion flows between the cells based on the input signals. Through wet-lab experiments that engineer the astrocytes
Michael Taynnan Barros, Phuong Doan, Meenakshisundaram Kandhavelu, Brendan Jennings, Sasitharan Balasubramaniam   +4 more
doaj   +1 more source