Results 41 to 50 of about 201,847 (294)
Combinatorial Control through Allostery [PDF]
Many instances of cellular signaling and transcriptional regulation involve switch-like molecular responses to the presence or absence of input ligands. To understand how these responses come about and how they can be harnessed, we develop a statistical ...
Einav, Tal +3 more
core +6 more sources
A molecular mechanism for proton‐dependent gating in KcsA [PDF]
Activation gating in KcsA is elicited by changes in intracellular proton concentration. Thompson et al.[1] identified a charge cluster around the inner gate that plays a key role in defining proton activation in KcsA. Here, through functional and spectroscopic approaches, we confirmed the role of this charge cluster and now provide a mechanism of pH ...
Cuello, Luis G. +4 more
openaire +2 more sources
A Fluorogenic Biosensor for Direct Detection of Vibrio vulnificus, a Climate Change Biomarker
Vibrio vulnificus, a marine pathogen and climate change biomarker, poses serious risks to human and animal health through seafood consumption and seawater exposure. Rapid detection methods are urgently needed for both vibriosis diagnosis and surveillance
M. Nieves Aranda +8 more
doaj +1 more source
Quantum-gate implementation in permanently coupled AF spin rings without need of local fields
We propose a scheme for the implementation of quantum gates which is based on the qubit encoding in antiferromagnetic molecular rings. We show that a proper engineering of the intercluster link would result in an effective coupling that vanishes as far ...
Affronte, M. +4 more
core +1 more source
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Molecular states in carbon nanotube double quantum dots
We report electrical transport measurements through a semiconducting single-walled carbon nanotube (SWNT) with three additional top-gates. At low temperatures the system acts as a double quantum dot with large inter-dot tunnel coupling allowing for the ...
C. Hoffmann +9 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Gated Nanosensor for Sulphate-Reducing Bacteria Detection
Desulfovibrio vulgaris is an anaerobic microorganism belonging to the group of sulphate-reducing bacteria (SRB). SRB form biofilms on metal surfaces in water supply networks, producing a microbiologically influenced corrosion (MIC). This process produces
Alba López-Palacios +10 more
doaj +1 more source
A modular design of molecular qubits to implement universal quantum gates
The physical implementation of quantum information processing requires individual qubits and entangling gates. Here, the authors demonstrate a modular implementation through chemistry, assembling molecular {Cr7Ni} rings acting as qubits, with ...
Jesús Ferrando-Soria +11 more
doaj +1 more source
Chemical Artificial Intelligence (CAI) is a brand-new research line that exploits molecular, supramolecular, and systems chemistry in wetware (i.e., in fluid solutions) to imitate some performances of human intelligence and promote unconventional ...
Pier Luigi Gentili, Pasquale Stano
doaj +1 more source

