Results 111 to 120 of about 5,499,417 (372)

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Portrayal of psychiatric genetics in Australian print news media, 1996-2009 [PDF]

, 2011
Objective: To investigate how Australian print news media portray psychiatric genetics. Design and setting: Content and framing analysis of a structured sample of print news items about psychiatric genetics published in Australian newspapers between 1996
Bonfiglioli, C, Meiser, B, Mitchell, PB, Schofield, PR, Wilde, A   +4 more
core   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Mechanisms and kinetic assays of aminoacyl‐tRNA synthetases

FEBS Letters, EarlyView.
Igor Zivkovic, Morana Dulic, Ita Gruic‐Sovulj   +2 more
wiley   +1 more source

Ligula intestinalis (Cestoda: Pseudophyllidea): an ideal fish-metazoan parasite model? [PDF]

, 2010
Since its use as a model to study metazoan parasite culture and in vitro development, the plerocercoid of the tapeworm, Ligula intestinalis, has served as a useful scientific tool to study a range of biological factors, particularly within its fish ...
Carter, V, Dufour, S, Hoole, D
core   +1 more source

The molecular genetics of colorectal cancer

Frontline Gastroenterology, 2013
Colorectal cancer is a common but heterogeneous disease, which arises through the accumulation of genetic mutations. Knowledge of the molecular basis of colorectal cancer has advanced at a rapid pace in recent years, reflecting progress made in the field
I. Ewing, J. Hurley, Eleni Josephides, A. Millar   +3 more
semanticscholar   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Natural history of Arabidopsis thaliana and oomycete symbioses [PDF]

, 2008
Molecular ecology of plant–microbe interactions has immediate significance for filling a gap in knowledge between the laboratory discipline of molecular biology and the largely theoretical discipline of evolutionary ecology.
A. Falk, A. H. Ellingboe, A. H. Ellingboe, A. J. Slusarenko, A. P. Rehmany, A. P. Rehmany, A. Riethmüller, A. Roetschi, Arabidopsis Genome Initiative, B. F. Holt, B. M. Tyler, C. Azevedo, C. D. Preston, C. Damgaard, D. Jirage, E. B. Holub, E. B. Holub, E. B. Holub, E. B. Holub, E. B. Holub, E. B. Holub, E. B. Holub, E. B. Holub, E. G. Bakker, E. Gäumann, E. Koch, E. O. Wilson, E. Speulman, Eric B. Holub, G. Lindau, H. Jönsson, H. Takahashi, H. Voglmayr, H.-M. Chou, J. E. Parker, J. E. Parker, J. Glazebrook, J. Glazebrook, J. M. McDowell, J. M. McDowell, J. N. Thompson, J. N. Thompson, J. N. Thompson, J. O. Borevitz, J. Silvertown, J. Song, J. Staal, J. Win, K. A. Shen, K. Century, K. Kazan, K. Lawton, K. S. Century, K. S. Thompson, L. E. Rose, M. A. Botella, M. A. Botella, M. B. Cooley, M. Damme Van, M. G. M. Aarts, M. Göker, M. H. Borhan, M. H. Borhan, M. J. Austin, M. Tör, N. Aarts, N. Gunn, O. Constantinescu, P. Ayers, P. D. Bittner-Eddy, P. Prusinkiewicz, P. R. Muskett, P. Tornero, Q. H. Shen, R. F. Warren, R. F. Warren, R. Gomulkiewicz, R. L. Allen, R. M. Clark, S. Kamoun, S. McCouch, S. R. Grant, S. Segal, T. Eulgem, T. Eulgem, T. Mitchell-Olds, W. Gassmann, X. Tang   +87 more
core   +2 more sources

Biological and technical complexities in analyzing extracellular vesicle immune interactions in B‐cell malignancies

FEBS Letters, EarlyView.
Daniel Bachurski, Michael Hallek
wiley   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source