Results 91 to 100 of about 908,779 (266)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Valency-based molecular descriptors of Bakelite network BNmn$B\text N_{m}^{n}$

Open Chemistry, 2019
Bakelite network BNmn$BN_{m}^{n}$is a molecular graph of bakelite, a pioneering and revolutionary synthetic polymer (Thermosetting Plastic) and regarded as the material of a thousand uses. In this paper, we aim to compute various degree-based topological
Ahmad Maqsood, Javaid Muhammad, Saeed Muhammad, Jung Chahn Yong   +3 more
doaj   +1 more source

Prediction of the Atomization Energy of Molecules Using Coulomb Matrix and Atomic Composition in a Bayesian Regularized Neural Networks

, 2019
Exact calculation of electronic properties of molecules is a fundamental step for intelligent and rational compounds and materials design. The intrinsically graph-like and non-vectorial nature of molecular data generates a unique and challenging machine ...
A Mauri, AK Rappé, D Xue, DJC MacKay, DJC Mackay, DJC Mackay, FR Burden, G Hugh, G Montavon, K Hansen, KA Aho, Kishore K. Reddy, LC Blum, M Rupp, M Rupp, OA Lilienfeld Von, R Guha, SJ Gorzynski   +17 more
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

M-Polynomials and Degree-Based Topological Indices of VC₅C₇[p,q] and HC₅C₇[p,q] Nanotubes

IEEE Access, 2019
Analysts are creating materials, for example, a carbon nanotube-based composite created by NASA that bends when a voltage is connected. Applications incorporate the use of an electrical voltage to change the shape (transform) of airship wings and ...
Jia-Bao Liu, Muhammad Younas, Mustafa Habib, Muhammad Yousaf, Waqas Nazeer   +4 more
doaj   +1 more source

Bayesian hierarchical reconstruction of protein profiles including a digestion model [PDF]

, 2011
Introduction : Mass spectrometry approaches are very attractive to detect protein panels in a sensitive and high speed way. MS can be coupled to many proteomic separation techniques.
Gerfault, Laurent, Giovannelli, Jean-François, Grangeat, Pierre, Szacherski, Pascal   +3 more
core   +2 more sources

Quantum statistics on graphs

, 2011
Quantum graphs are commonly used as models of complex quantum systems, for example molecules, networks of wires, and states of condensed matter. We consider quantum statistics for indistinguishable spinless particles on a graph, concentrating on the ...
Avron J. E., de Gennes P. G., Duck I., Dummit D. S., Harrison J. M., Hatcher A., Keating J. P.   +6 more
core   +1 more source

Graph Residual Flow for Molecular Graph Generation

, 2019
Statistical generative models for molecular graphs attract attention from many researchers from the fields of bio- and chemo-informatics. Among these models, invertible flow-based approaches are not fully explored yet. In this paper, we propose a powerful invertible flow for molecular graphs, called graph residual flow (GRF).
Honda, Shion, Akita, Hirotaka, Ishiguro, Katsuhiko, Nakanishi, Toshiki, Oono, Kenta   +4 more
openaire   +2 more sources

More hyperenergetic molecular graphs

Journal of the Serbian Chemical Society, 2000
If G is a molecular graph and ?1,?2,... ?n are its eigenvalues, then the energy of G is equal to E(G) = |?1|+|?2|+ ... +|?n|. This energy cannot exceed the value n?n-1 ? n3/2. The graph G is said to be hyperenergetic if E(G)>2n-2. We describe the construc?tion of hyperenergetic graphs G for which E(G)?1/2 n3/2.
Koolen, Jack H., Moulton, Vincent, Gutman, Ivan, Vidovic, Dusica   +3 more
openaire   +3 more sources