Results 201 to 210 of about 1,608,476 (265)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Detection of invasive Aedes vittatus mosquitoes in Jamaica: molecular identification and surveillance implications. [PDF]

Parasit Vectors
Noble SAA, Ali RLMN, Wilson-Clarke CF, Khouri NK, Norris DE, Sandiford SL.   +5 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Molecular identification and phylogenetic analysis of spotted fever Rickettsiae in peripheral blood from suspected Rickettsiosis cases in Sri Lanka. [PDF]

BMC Infect Dis
Shiffana S, Kularatne SAM, Rajapakse RPVJ, Thilakarathne DS.   +3 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Molecular identification and optimization of indole acetic acid production by Fusarium oxysporum AUMC 16,438 for biofertilizer application. [PDF]

Sci Rep
Maan SA, Abdelhamid SA.
europepmc   +1 more source

Molecular Identification and Phylogenetic Characterization of Yeast Species Isolated from Complete Denture in Sulaymaniyah, Iraq. [PDF]

Pol J Microbiol
Mohammed SA, Shekhany KA.
europepmc   +1 more source

Pyrene morphology and molecular identification of some garden ornamental palms of the family Arecaceae based on the plastid rbcL gene in Egypt morphological and molecular identification of ornamental palms (Arecaceae) in Egypt based on pyrene traits and rbcL gene sequence. [PDF]

BMC Plant Biol
El-Demerdash MM, El-Sayed ASA, Yassin MA, Elsehely HH.   +3 more
europepmc   +1 more source

Prevalence and molecular identification of <i>Giardia intestinalis</i> in water buffalo in Iraq. [PDF]

Open Vet J
Alseady HH, Al-Dabbagh SMK, Al-Shalah SAJ.   +2 more
europepmc   +1 more source

Morphological and Molecular Identification of <i>Trichosporon asahii</i> Caused Oral Thrush in Neonates. [PDF]

Clin Case Rep
Gherbawy YA, Puscasiu D, Baddar A, Yassein AS, El-Dawy EGAM.   +4 more
europepmc   +1 more source