Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma+9 more
wiley +1 more source
Radiation-Force Assisted Targeting Facilitates Ultrasonic Molecular Imaging [PDF]
Shukui Zhao+5 more
openalex +3 more sources
Advances in Molecular Imaging of VEGFRs: Innovations in Imaging and Therapeutics. [PDF]
Karimi H+8 more
europepmc +1 more source
Molecular Imaging: Unveiling Metabolic Abnormalities in Pancreatic Cancer. [PDF]
Wang H, Gui Y, Lv K.
europepmc +1 more source
Quantification of molecular and anatomical target contours of head and neck cancer to facilitate image-guided therapy during IMRT [PDF]
Christopher Scarfone+6 more
openalex +1 more source
Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren+16 more
wiley +1 more source
Advances in Molecular Imaging for the Early Detection and Management of Alzheimer's Disease. [PDF]
Goel SA+4 more
europepmc +1 more source
Molecular Markers Of Different Elemental Compositions Bioengineered For Simultaneous Detection And Localization Of Multiple Biomolecules With Energy And Wavelength Dispersive Spectroscopic Imaging [PDF]
Marek Malecki+4 more
openalex +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo+18 more
wiley +1 more source
Coelenterazine Analogs for Bioassays and Molecular Imaging. [PDF]
Kim SB, Kamiya G, Furuta T, Maki SA.
europepmc +1 more source