Results 121 to 130 of about 12,554,924 (329)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Knife edge skimming for improved separation of molecular species by the deflector

, 2018
A knife edge for shaping a molecular beam is described to improve the spatial separation of the species in a molecular beam by the electrostatic deflector.
Bieker, Helen, Długołęcki, Karol, Gumprecht, Lars, Johny, Melby, Kierspel, Thomas, Küpper, Jochen, Mullins, Terry, Onvlee, Jolijn, Trippel, Sebastian, Ye, Hong   +9 more
core   +2 more sources

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

The IntAct molecular interaction database in 2010

Nucleic Acids Res., 2009
IntAct is an open-source, open data molecular interaction database and toolkit. Data is abstracted from the literature or from direct data depositions by expert curators following a deep annotation model providing a high level of detail.
Bruno Aranda, P. Achuthan, Y. Alam-Faruque, Irina M. Armean, A. Bridge, C. Derow, M. Feuermann, A. Ghanbarian, Samuel Kerrien, J. Khadake, J. Kerssemakers, C. Leroy, Michael P. Menden, M. Michaut, L. Montecchi-Palazzi, S. N. Neuhauser, S. Orchard, V. Perreau, B. Roechert, K. V. Eijk, H. Hermjakob   +20 more
semanticscholar   +1 more source

The Oseen-Frank limit of Onsager's molecular theory for liquid crystals

, 2016
We study the relationship between Onsager's molecular theory and the Oseen-Frank theory for nematic liquid crystals. Under the molecular setting, we consider the free energy that includes the effects of nonlocal molecular interactions.
Liu, Yuning, Wang, Wei
core   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Detection of Binding Site Molecular Interaction Field Similarities

Journal of Chemical Information and Modeling, 2015
Protein binding-site similarity detection methods can be used to predict protein function and understand molecular recognition, as a tool in drug design for drug repurposing and polypharmacology, and for the prediction of the molecular determinants of ...
Matthieu Chartier, R. Najmanovich
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Viruses and Autoimmunity: A Review on the Potential Interaction and Molecular Mechanisms

Viruses, 2019
For a long time, viruses have been shown to modify the clinical picture of several autoimmune diseases, including type 1 diabetes (T1D), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren’s syndrome (SS), herpetic stromal keratitis ...
M. Smatti, F. Cyprian, Gheyath K Nasrallah, A. A. Al Thani, Ruba Almishal, H. Yassine   +5 more
semanticscholar   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source