Results 101 to 110 of about 8,317,788 (302)

Thermodynamics of dissolution and infrared-spectroscopy of solid dispersions of phenacetin

Journal of Advanced Pharmaceutical Technology & Research, 2016
In this work enthalpies of dissolution in water of polyethylene glycols (PEGs) having an average molecular weight of 1000 and 1400, Pluronic-F127, phenacetin as well as the composites prepared from them were measured using solution calorimetry at 298.15 ...
Alexander V Gerasimov, Mikhail A Varfolomeev, Marat A Ziganshin, Valery V Gorbatchuk, Il′naz T Rakipov, Alexander E Klimovitskii, Liana S Usmanova   +6 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Simulation of a molecular QCA wire [PDF]

, 2013
Molecular Quantum Dot Cellular Automata (MQCA) are among the most promising emerging technologies for the expected theoretical operating frequencies (THz), the high device densities and the non-cryogenic working temperature.
Demarchi, Danilo, Graziano, Mariagrazia, Pulimeno, Azzurra, Piccinini, Gianluca   +3 more
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

G-quadruplexes in the proximity 3′-UTR enhances alternative polyadenylation of Neogenin 1

iScience
Summary: Polyadenylation is a crucial step in mRNA maturation. Fifty percent of the time alternative polyadenylation sites (PASs) are used instead of canonical ones, affecting the length of the transcripts’ 3′-UTRs.
Pauline Lejault, François Bolduc, Marc-Antoine Turcotte, Jean Pierre Perreault   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Identification of Lung Cancer metabolomics profile and molecular interactions using bioinformatic methods

Basic & Clinical Cancer Research
Lung cancer represents a significant public health challenge, representing a considerable contributor to cancer-related mortality. However, the current diagnostic methods for early detection of lung cancer are constrained by various limitations, such as
Haniyeh Rafiepoor, Alireza Ghorbankhanloo, Saman Asadi, Maryam Edalatifard, Seyyed Hamidreza Abtahi, Saeid Amanpour   +5 more
doaj   +1 more source

Microscopy of molecular interactions [PDF]

Cytometry Part A, 2013
György, Vereb, Stephen J, Lockett
openaire   +2 more sources

Sequence Motifs in MADS Transcription Factors Responsible for Specificity and Diversification of Protein-Protein Interaction [PDF]

, 2010
Protein sequences encompass tertiary structures and contain information about specific molecular interactions, which in turn determine biological functions of proteins.
Angenent, G.C., Martijn Fiers, Roeland C H J van Ham, Roeland C. H. J. van Ham, Morabito Giuseppa, Ham, R.C.H.J., van, Aalt D J van Dijk, Angenent Gerco C., Immink, R.G.H., van Dijk, A.D.J., Richard G H Immink, van Dijk Aalt D. J., Morabito, G., van Ham Roeland C. H. J., Dijk, A.D.J., van, Fiers, M.A., Richard G. H. Immink, Giuseppa Morabito, van Ham, R.C.H.J., Aalt D. J. van Dijk, Immink Richard G. H., Gerco C Angenent, Gerco C. Angenent, Fiers Martijn   +23 more
core   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source