Results 91 to 100 of about 3,493,062 (307)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Synergistic modification of hot-melt extrusion and nobiletin on the multi-scale structures, interactions, thermal properties, and in vitro digestibility of rice starch

Frontiers in Nutrition
BackgroundRice starch has high digestibility due to its large carbohydrate content. Synergistic modification of hot-melt extrusion (HME) and additives such as flavonoids, hydrocolloids, proteins, lipids, and other additives has the tendency to retard the
Zhihong Zhang, Ying Feng, Honglan Wang, Hai He, Hai He   +4 more
doaj   +1 more source

A Process Calculus for Molecular Interaction Maps

, 2009
We present the MIM calculus, a modeling formalism with a strong biological basis, which provides biologically-meaningful operators for representing the interaction capabilities of molecular species.
Andrea Maggiolo-Schettini, Aureliano Rama, Aviv Regev, Aviv Regev, Aviv Regev, Aviv Regev, Aviv Regev, Corrado Priami, Corrado Priami, Corrado Priami, Cosimo Laneve, Cristian Versari, Federica Ciocchetta, Federica Ciocchetta, Gabriel Ciobanu, Giovanni Pardini, Hiroaki Kitano, Kurt W. Kohn, Kurt W. Kohn, Kurt W. Kohn, Linda Brodo, Luca Bortolussi, Luca Cardelli, M. Curti, Marc Chiaverini, Nathalie Chabrier-Rivier, Paolo Milazzo, Roberto Barbuti, Roberto Barbuti, Roberto Barbuti, Roberto Barbuti, Roberto Barbuti, Robin Milner, Vincent Danos   +33 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Nuclear talin-1 provides a bridge between cell adhesion and gene expression

iScience
Summary: Talin-1 (TLN1) is best known to activate integrin receptors and transmit mechanical stimuli to the actin cytoskeleton at focal adhesions. However, the localization of TLN1 is not restricted to focal adhesions.
Alejandro J. Da Silva, Hendrik S.E. Hästbacka, Mikael C. Puustinen, Jenny C. Pessa, Jens C. Luoto, Erika Sundström, Benjamin T. Goult, Guillaume Jacquemet, Eva Henriksson, Lea Sistonen   +9 more
doaj   +1 more source

Structural insight into TPX2-stimulated microtubule assembly [PDF]

, 2017
During mitosis and meiosis, microtubule (MT) assembly is locally upregulated by the chromatin-dependent Ran-GTP pathway. One of its key targets is the MT-associated spindle assembly factor TPX2.
Nogales, Eva, Roostalu, Johanna, Surrey, Thomas, Zhang, Rui   +3 more
core   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Interaction-induced negative differential resistance in asymmetric molecular junctions

, 2010
Combining insights from quantum chemistry calculations with master equations, we discuss a mechanism for negative differential resistance (NDR) in molecular junctions, operated in the regime of weak tunnel coupling.
Flensberg, Karsten, Hedegård, Per, Leijnse, Martin, Nielsen, Mogens Brøndsted, Sun, Wei   +4 more
core   +1 more source

Electrostatic Molecular Interaction from X-ray Diffraction Data. I. Development of the Method; Test on Pyrazine [PDF]

, 1981
Electrostatic interaction is often an important part of the total interaction between molecules. It depends on the electron density distribution in the participating molecules, which can, in principle, be determined by X-ray diffraction methods. A method
Feil, Dirk, Moss, Grant
core   +3 more sources