Results 91 to 100 of about 8,317,788 (302)

Reflection 7 [PDF]

open access: yes, 2011
The Report on Fieldwork in Amakusa, The 5th ICIS International Workshop, The 4th International Symposium, International Academic Symposium, Cultural Interaction Studies on Food (6), Activities and Announcements, Solicitation of Submissions for the ...
Institute, For Cultural Interaction Studies Kansai University   +1 more
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Shedding light on the interaction of human anti-apoptotic Bcl-2 protein with ligands through biophysical and in silico studies

open access: yes, 2019
This work was supported by the Applied Molecular Biosciences Unit-UCIBIO which is financed by national funds from FCT/MCTES (UID/Multi/04378/2019). JM thanks Fundacao para a Ciencia e a Tecnologia (FCT) (SFRH/BPD/97719/2013) Portugal.Bcl-2 protein is ...
Otrelo-Cardoso, Ana Rita   +16 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Insights into T cell recognition of antigen: Significance of two-dimensional kinetic parameters

open access: yesFrontiers in Immunology, 2012
The kinetic parameters governing T cell activation have been intensely studied for over a decade. However, the details of how the various aspects of receptor:ligand interactions culminate in T cell activation remains shrouded in mystery.
Lindsay J Edwards   +4 more
doaj   +1 more source

Nanoscale Fluid Transport: From Molecular Signatures to Applications [PDF]

open access: yes, 2015
Motivated by the fact that many novel fluid transport phenomena have been discovered at nano length scales, in this thesis I use molecular dynamics simulations to investigate how a solid surface affects the fluid properties and fluid transport in ...
Ho, TA
core  

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Dicistrovirus-Host Molecular Interactions

open access: yesCurrent Issues in Molecular Biology, 2019
Members of the family Dicistroviridae are small RNA viruses containing a monopartite positive-sense RNA genome. Dicistroviruses mainly infect arthropods, causing diseases that impact agriculture and the economy. In this chapter, we provide an overview of current and past research on dicistroviruses including the viral life cycle, viral translational ...
Reid, Warsaba   +2 more
openaire   +2 more sources

The MintAct project and molecular interaction databases

open access: yes, 2016
Molecular interaction databases collect, organize, and enable the analysis of the increasing amounts of molecular interaction data being produced and published as we move towards a more complete understanding of the interactomes of key model organisms ...
Licata L.   +3 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

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