Results 161 to 170 of about 1,319,694 (261)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Can We Interpret Analyses of Etiologic Heterogeneity When Molecular Markers Are Used to Classify Tumors? [PDF]

Cancer Epidemiol Biomarkers Prev
Mooney SJ, Rundle AG.
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Development of immune-derived molecular markers for coronary heart disease via multimachine learning. [PDF]

iScience
Wang H, Du C, Yang T, Wang W, Zhou L, Gu L, Wang S, Gao W, Yan J, Wang L, Wang Q.   +10 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

OsteoNet: A deep learning framework linking cellular morphology to molecular markers for quantifying osteogenic differentiation. [PDF]

Comput Struct Biotechnol J
Kou T, Wang J, Zhou J, Cheng Y, Xu L, Xie J, Chen Y, Zhang T, Zhao S, Ying Y, Xin X, Xu X, Lu D, Hu X, Qiu C, Wang J, Cheng G, Lei S, Lyu Q, Pan Y, Cao T.   +20 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Commentary: The Case for Abandoning Therapeutic Chelation of Copper Ions in Alzheimer’s Disease

Frontiers in Neurology, 2017
Rosanna Squitti, Carlo Salustri, Mauro Rongioletti, Mariacristina Siotto   +3 more
doaj   +1 more source

No evidence of molecular markers of piperaquine resistance in southeastern Nigeria. [PDF]

Malar J
Ikegbunam M, Tzirtziganis V, Rodi M, Anagu L, Pessanha de Carvalho L, Inoue J, Held J.   +6 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source