Results 21 to 30 of about 8,494,354 (311)

Transcriptional analysis and target genes discovery of Pseudomonas aeruginosa biofilm developed ex vivo chronic wound model

open access: yesAMB Express, 2021
Bacterial biofilms formation is one of the major reasons for treatment failure in chronic wound infections. Therefore, diagnostic biomarkers remain the best option for prevention and treatment of chronic wound infections by biofilms.
Xiaojuan Tan   +6 more
doaj   +1 more source

Alkaline phosphatase LapA regulates quorum sensing–mediated virulence and biofilm formation in Pseudomonas aeruginosa PAO1 under phosphate depletion stress

open access: yesMicrobiology Spectrum, 2023
Among various environmental stresses, the depletion of inorganic phosphate, which is an important signaling molecule that modulates virulence production, is notable. In our previous study, we demonstrated that lapA, encoding alkaline phosphatase, plays a
Xiaojuan Tan   +8 more
doaj   +1 more source

Molecular Mechanism of the Anti-Inflammatory Action of Heparin

open access: yes, 2021
Our objective is to reveal the molecular mechanism of the anti-inflammatory action of low-molecular-weight heparin (LMWH) based on its influence on the activity of two key cytokines, IFNγ and IL-6.
Peicho Petkov   +23 more
core   +1 more source

The role of pharmacology in anticancer drug development

open access: yesADMET and DMPK, 2018
Drug development consists of many sequential and parallel steps; failure in one of the steps can lead to discontinuation of the process. The process is time-consuming and very expensive, especially the clinical phase.
Godefridus J. Peters   +3 more
doaj   +1 more source

Exploring the Mechanism of the Envelope Protein of SARS-CoV-2: A Molecular Dynamics Study [PDF]

open access: yes, 2023
According to the World Health Organization, the number of people infected with COVID-19 continues to increase globally, highlighting the urgent need for effective treatments.
Sanika, Dolas, Gaurav, Sharma
core   +1 more source

Elucidation of molecular mechanism of filovirus entry.

open access: yes, 2005
Elucidation of molecular mechanism of filovirus ...
Balaji. Manicassamy (7977065)
core   +4 more sources

A Molecular-Level Mechanism of the Biological N2 Fixation [PDF]

open access: yes, 2019
We present a detailed molecular-level mechanism for the biological fixation of atmospheric nitrogen into ammonia. The mechanism is based on a series of electronic structure calculations and provides insight into the key question of what it is that the ...
Vanessa Jane, Bukas   +1 more
core   +2 more sources

Molecular mechanisms of etoposide

open access: yesEXCLI journal, 2015
EXCLI Journal ; Vol.
Montecucco A, Zanetta F, Biamonti G
openaire   +3 more sources

Towards molecular systems biology of gene transcription and regulation [PDF]

open access: yes, 2010
Ten years after the determination of the RNA polymerase 11 structure, the basic mechanism of mRNA synthesis during gene transcription is known. In the future, the initiation and regulation of transcription must be studied with a combination of structural
Cramer, P.   +2 more
core   +1 more source

Molecular mechanisms of luteinization [PDF]

open access: yesObstetrics & Gynecology Science, 2014
Dynamic changes in steroidogenesis occur in ovarian granulosa cells during ovulation after the LH surge. The ovulatory LH surge induces rapid up-regulation of steroidogenic acute regulatory (StAR) protein and rapid down-regulation of aromatase (Cyp19a1) in granulosa cells undergoing luteinization during ovulation.
openaire   +2 more sources

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