Results 121 to 130 of about 14,308,960 (385)

Cellular bases for human atrial fibrillation [PDF]

, 2008
Atrial fibrillation (AF) causes substantial morbidity and mortality. It may be triggered and sustained by either reentrant or nonreentrant electrical activity. Human atrial cellular refractory period is shortened in chronic AF, likely aiding reentry. The
Andrew C. Rankin, Antony J. Workman, Balana, Bosch, Brandt, Brundel, Brundel, Cha, Cha, Cha, Cheng, Christ, Dobrev, Dobrev, Dobrev, Ehrlich, Fatkin, Gaborit, Grammer, Greiser, Hove-Madsen, Kathleen A. Kane, Klein, Kneller, Koumi, Koumi, Le Grand, Mansourati, Marshall, Marshall, Ouadid, Pandit, Pau, Pau, Raine, Redpath, Schotten, Schreieck, Schreieck, Skasa, Van Wagoner, Van Wagoner, Vest, Voigt, Wijffels, Wit, Workman, Workman, Workman, Workman, Wu, Zhang   +51 more
core   +2 more sources

Molecular Mechanisms of Treatment Resistance in Glioblastoma

International Journal of Molecular Sciences, 2020
Glioblastoma is the most common malignant primary brain tumor in adults and is almost invariably fatal. Despite our growing understanding of the various mechanisms underlying treatment failure, the standard-of-care therapy has not changed over the last ...
Alexander Ou, W. Yung, N. Majd
semanticscholar   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Dynamics of Proton Transfer in Mesoscopic Clusters

, 1996
Proton transfer rates and mechanisms are studied in mesoscopic, liquid-state, molecular clusters. The proton transfer occurs in a proton-ion complex solvated by polar molecules comprising the cluster environment.
Raymond Kapral, Styliani Consta, Warshel A.   +2 more
core   +2 more sources

Molecular mechanisms controlling the phenotype and the EMT/MET dynamics of hepatocyte [PDF]

, 2014
The complex spatial and paracrine relationships between the various liver histotypes are essential for proper functioning of the hepatic parenchymal cells.
Fausto N, Lazarevich NL, Michelotti GA, Omenetti A, Spagnoli FM, Treyer A, Valdes F   +6 more
core   +3 more sources

Hibernation Impairs Odor Discrimination – Implications for Alzheimer’s Disease

Frontiers in Neuroanatomy, 2019
Reversible formation of PHF-like phosphorylated tau, an early feature of Alzheimer’s disease (AD) was previously shown to occur in torpor during hibernation in the Golden hamster (Syrian hamster, Mesocricetus auratus).
Torsten Bullmann, Emily Feneberg, Tanja Petra Kretzschmann, Vera Ogunlade, Max Holzer, Thomas Arendt   +5 more
doaj   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

Molecular mechanisms of epilepsy [PDF]

Nature Neuroscience, 2015
Decades of experimental work have established an imbalance of excitation and inhibition as the leading mechanism of the transition from normal brain function to seizure. In epilepsy, these transitions are rare and abrupt. Transition processes incorporating positive feedback, such as activity-dependent disinhibition, could provide these uncommon timing ...
openaire   +2 more sources

A Systematic Approach to Identifying Protein-Ligand Binding Profiles on a Proteome Scale [PDF]

, 2008
Identification of protein-ligand interaction networks on a proteome scale is crucial to address a wide range of biological problems such as correlating molecular functions to physiological processes and designing safe and efficient therapeutics.
Lei Xie, Li Xie, Nancy Buchmeier, Philip Bourne   +3 more
core   +2 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source