Results 101 to 110 of about 3,444,468 (295)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
A Novel Information Retrieval Model for High-Throughput Molecular Medicine Modalities
Cancer Informatics, 2009 Significant research has been devoted to predicting diagnosis, prognosis, and response to treatment using high- throughput assays. Rapid translation into clinical results hinges upon efficient access to up-to-date and high-quality molecular medicine ...
Constantin F. Aliferis +5 more
doaj
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Transfusion medicine and molecular genetic methods
International Journal of Preventive Medicine, 2018 Transfusion procedures are always complicated by potential genetic mismatching between donor and recipient. Compatibility is determined by several major antigens, such as the ABO and Rhesus blood groups. Matching for other blood groups (Kell, Kidd, Duffy,
Rozieyati Mohamed Saleh +4 more
doaj +1 more source
The Molecular Medicine Informatics Model (MMIM) [PDF]
, 2007 In 2005, a major collaboration in Melbourne Australia successfully completed implementing a major medical informatics infrastructure – this is now being used for discovery research and has won significant expansion funding for 2006 - 2009.
Hibbert, Marienne
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Current themes in molecular pediatrics: molecular medicine and its applications
Italian Journal of Pediatrics, 2010 We focus on themes that are derived from clinical practice and research in the field of genetic diseases of bone and inborn errors of metabolism but may be of more general interest as they indicate some trends in molecular medicine as related to ...
Garavelli Livia, Superti-Furga Andrea
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Nuclear transmembrane protein 199 promotes immune escapes by up-regulating programmed death ligand 1
iScienceSummary: The function of transmembrane protein 199 (TMEM199) in cancer development has rarely been studied thus far. We report the nuclear localization of the TMEM199 protein and further analyzed the truncated fractions that mediate its nuclear ...
Wulin You +8 more
doaj +1 more source
, 2013 The salamander is the only tetrapod that regenerates complex body structures throughout life. Deciphering the underlying molecular processes of regeneration is fundamental for regenerative medicine and developmental biology, but the model organism had ...
Khattak, Shahryar +9 more
core +3 more sources