Results 91 to 100 of about 3,444,468 (295)

Activity of nAChRs containing α9 subunits modulates synapse stabilization via bidirectional signaling programs [PDF]

, 2009
Although the synaptogenic program for cholinergic synapses of the neuromuscular junction is well known, little is known of the identity or dynamic expression patterns of proteins involved in non-neuromuscular nicotinic synapse development.
Elgoyhen, Ana Belen, Murthy, Vidya, Taranda, Julian, Vetter, Douglas E.   +3 more
core   +1 more source

Internal medicine and molecular biology—molecular medicine [PDF]

Journal of Internal Medicine, 1991
P, Björntorp, J, Nilsson, G, Holm
openaire   +2 more sources

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

KLF13-mediated CES2 upregulation via p300-dependent acetylation sensitizes gastric cancer cells to irinotecan

iScience
Summary: Irinotecan (CPT-11) is a key chemotherapeutic agent for gastric cancer (GC), but its efficacy is limited by variable patient responses. The activation of CPT-11 to its active form, SN-38, depends on the enzyme carboxylesterase 2 (CES2), yet the ...
Hai-bin Zhang, Ren-hao Hu, Ke-hui Zhang, Xi-mao Cui, Shun Zhang   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Multimodal artificial intelligence in urologic precision oncology: from algorithm to translational medicine (a systemized narrative review)

Frontiers in Oncology
Precision oncology in urology increasingly depends on integrating heterogeneous data, including multiparametric imaging, histopathology, genomics, and clinical variables.
Farid Rajaee Rizi, Farid Rajaee Rizi, Maryam Sadat Jamadi, Samin Rahimi, Moein Bighamian, Pouya Paidar, Mohammad Javad Taki, Nazila Bahmaie   +7 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Tissue Iron Predicts Metformin Responsiveness in a Mouse Model and in Humans with Type 2 Diabetes

Diabetes, Metabolic Syndrome and Obesity
Alexandria V Harrison,1,* Chinenye O Usoh,1,2,* Sandy Sink,1 Shalini Jain,1 Holly M Berry-Price,1 Felipe R Lorenzo,1 Donald A McClain1,2 1Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, Wake Forest ...
Harrison AV, Usoh CO, Sink S, Jain S, Berry-Price HM, Lorenzo FR, McClain DA   +6 more
doaj  

Icariin interacts with IGFBP3 to alleviate diabetic cataract through PI3K/AKT signaling pathway

iScience
Summary: Diabetic cataract (DC), a well-recognized complication in diabetic patients, can progress to blindness if not adequately managed, with currently limited therapeutic strategies.
Yakun Wang, Wenxian Yang, Hangjia Zuo, Shuhao Zeng, Xianyang Liu, Fan Cao, Hui Yang, Shangze Gao, Meng Tian, Xiang Gao, Yongguo Xiang, Fanfan Huang, Baorui Chu, Chao Wu, Hui Feng, Wenjuan Wan, Shijie Zheng, Shengping Hou, Ke Hu   +18 more
doaj   +1 more source