Results 71 to 80 of about 2,276,422 (251)

Multimodal artificial intelligence in urologic precision oncology: from algorithm to translational medicine (a systemized narrative review)

Frontiers in Oncology
Precision oncology in urology increasingly depends on integrating heterogeneous data, including multiparametric imaging, histopathology, genomics, and clinical variables.
Farid Rajaee Rizi, Farid Rajaee Rizi, Maryam Sadat Jamadi, Samin Rahimi, Moein Bighamian, Pouya Paidar, Mohammad Javad Taki, Nazila Bahmaie   +7 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Icariin interacts with IGFBP3 to alleviate diabetic cataract through PI3K/AKT signaling pathway

iScience
Summary: Diabetic cataract (DC), a well-recognized complication in diabetic patients, can progress to blindness if not adequately managed, with currently limited therapeutic strategies.
Yakun Wang, Wenxian Yang, Hangjia Zuo, Shuhao Zeng, Xianyang Liu, Fan Cao, Hui Yang, Shangze Gao, Meng Tian, Xiang Gao, Yongguo Xiang, Fanfan Huang, Baorui Chu, Chao Wu, Hui Feng, Wenjuan Wan, Shijie Zheng, Shengping Hou, Ke Hu   +18 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

A Novel Information Retrieval Model for High-Throughput Molecular Medicine Modalities

Cancer Informatics, 2009
Significant research has been devoted to predicting diagnosis, prognosis, and response to treatment using high- throughput assays. Rapid translation into clinical results hinges upon efficient access to up-to-date and high-quality molecular medicine ...
Constantin F. Aliferis, Cynthia S. Gadd, Daniel R. Masys, Pierre P. Massion, Firas H. Wehbe, Steven H. Brown   +5 more
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transfusion medicine and molecular genetic methods

International Journal of Preventive Medicine, 2018
Transfusion procedures are always complicated by potential genetic mismatching between donor and recipient. Compatibility is determined by several major antigens, such as the ABO and Rhesus blood groups. Matching for other blood groups (Kell, Kidd, Duffy,
Rozieyati Mohamed Saleh, Zulkafli Zefarina, Nor Fazila Che Mat, Geoffrey Keith Chambers, Hisham Atan Edinur   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Nuclear transmembrane protein 199 promotes immune escapes by up-regulating programmed death ligand 1

iScience
Summary: The function of transmembrane protein 199 (TMEM199) in cancer development has rarely been studied thus far. We report the nuclear localization of the TMEM199 protein and further analyzed the truncated fractions that mediate its nuclear ...
Wulin You, Hue Luu, Meili Li, Zhiyu Chen, Fangchao Li, Yanfei Zhang, Mingsheng Cai, Tong-chuan He, Jingjing Li   +8 more
doaj   +1 more source