Results 51 to 60 of about 3,444,468 (295)

Unique Molecular Features in High-Risk Histology Endometrial Cancers [PDF]

, 2019
Endometrial cancer is the most common gynecologic malignancy in the United States and the sixth most common cancer in women worldwide. Fortunately, most women who develop endometrial cancer have low-grade early-stage endometrioid carcinomas, and simple ...
Collins, Kaitlyn, Hawkins, Shannon M., Jones, Devin E., Pandita, Pooja, Wang, Xiyin   +4 more
core   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Harnessing Homalomena aromatica for green synthesis of AgNPs and unveiling therapeutic antioxidant and antibacterial activities

Green Chemistry Letters and Reviews
Green synthesis of silver nanoparticles (AgNPs) using Homalomena aromatica leaf extract as a reducing agent has garnered interest due to its eco-friendly nature and broad applications, particularly in molecular medicine.
Dipan Sarma, Badal K. Datta, Kuldip Gosai, Taha Alqahtani, Arabinda Ghosh, Daniel Ejim Uti   +5 more
doaj   +1 more source

Molecular medicine and viral infections: modern view on the problemand strategy of interrelations

Бюллетень сибирской медицины, 2008
The lecture presents basic directions of molecular medicine development. Special attention is devoted to prior direction of identification of molecular and genetic markers of predisposition to chronic course of socially important viral infections ...
N. V. Ryazantseva
doaj   +1 more source

Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapies [PDF]

, 2017
We would like to thank all patients whose samples were used in this study. We are also thankful to the Northern Ireland Biobank and Grampian Biorepository for providing us with tissue blocks and patient data; and Dr HG Coleman (Queen’s University Belfast)
A Gonçalves, Brendan Pang, Claire McGready, CM McCourt, D Barras, DT Le, E Vilar, Graeme I Murray, J Guinney, J Siehl, Jacqueline A James, K Masago, KJ Lastwika, M Arnold, M Lek, M Toyota, MA Alvi, Manuel Salto-Tellez, Marc-Aurel Fuchs, Mark Lawler, Maurice B Loughrey, MF Kane, ML Iacono, Muhammad A Alvi, NJ Llosa, Perry Maxwell, Philip Dunne, Richard H Wilson, Richard Turkington, RS Herbst, S Kakar, SC Casey, Stephen McQuaid, T Anthony, The Genomes Project C, U Nitsche, V Gopalan, Victoria Bingham, Wendy Moore, Y Xiao   +39 more
core   +2 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

The value proposition of molecular medicine. [PDF]

, 2012
Individualized patient management is rapidly evolving, driven by the emergence of insights in discovery, development, regulatory, and comparative effectiveness sciences.1-4 The pace of discovery is accelerating, enabled by platforms, including “omics ...
Terzic, Andre, Waldman, Scott A.
core   +2 more sources

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

Therapeutic Potential of CRISPR-Cas13 for RNA Virus Infections

Galician Medical Journal
CRISPR-Cas13 is a groundbreaking RNA-targeting tool that has emerged as a promising solution for diagnosing and treating RNA viruses, including SARS-CoV-2, influenza, and HIV.
Sharanagouda S. Patil, Krishna Prasanth Baalann, Danti Joseph, Sriram N, Nirmali Gogoi   +4 more
doaj   +1 more source

A Path to Implement Precision Child Health Cardiovascular Medicine. [PDF]

, 2017
Congenital heart defects (CHDs) affect approximately 1% of live births and are a major source of childhood morbidity and mortality even in countries with advanced healthcare systems. Along with phenotypic heterogeneity, the underlying etiology of CHDs is
Brian Reemtsen, J. Paul Finn, Juan Alejos, Marlin Touma, Marlin Touma, Nancy Halnon, Stanley F. Nelson, Yibin Wang, Yibin Wang   +8 more
core   +2 more sources