Results 31 to 40 of about 2,276,422 (251)

CHIP protects against septic acute kidney injury by inhibiting NLRP3-mediated pyroptosis

iScience, 2023
Summary: Septic acute kidney injury (S-AKI), the most common type of acute kidney injury (AKI), is intimately related to pyroptosis and oxidative stress in its pathogenesis.
Hao Zhang, Zebin Deng, Yilong Wang, Xiaoping Zheng, Lizhi Zhou, Shu Yan, Yinhuai Wang, Yingbo Dai, Yashpal.S. Kanwar, Fei Deng   +9 more
doaj   +1 more source

Central Nervous System Neuroblastoma, FOXR2‐Activated: A Pooled Analysis of Published Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) neuroblastoma, FOXR2‐activated, is a recently recognized entity in the WHO CNS5 classification, defined by activation of the FOXR2 transcription factor and unique histopathological features. This review synthesizes available literature and pooled clinical data, providing insight into demographics ...
Sudarshawn Damodharan, Mohamed S. Abdelbaki   +1 more
wiley   +1 more source

Research Advances in Adenomyosis-Related Signaling Pathways and Promising Targets

Biomolecules
Adenomyosis is a benign gynecological condition characterized by the proliferation of the endometrial stroma and glands into the myometrium, uterine volume enlargement, and peripheral smooth muscle hypertrophy.
Hongyu Zhang, Chaoming Li, Wenyan Li, Wenhu Xin, Tiansheng Qin   +4 more
doaj   +1 more source

Label-free approaches for extracellular vesicle detection

iScience, 2023
Summary: Extracellular vesicles (EVs) represent pivotal mediators in cell-to-cell communication. They are lipid-membranous carriers of several biomolecules, which can be produced by almost all cells.
Loredana Leggio, Greta Paternò, Silvia Vivarelli, Aurelio Bonasera, Bruno Pignataro, Nunzio Iraci, Giuseppe Arrabito   +6 more
doaj   +1 more source

Rational Use of Herbal Products in Pediatric Patients Treated With Anticancer Drugs in the European Union

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The use of herbal medical preparation (HMP) is rising among pediatric oncology patients, often to manage treatment‐related symptoms. Their effectiveness remains uncertain, and the risk of herb–drug interactions is underestimated.
Orianne Mahot, Mathieu Corvaisier, Laurence Spiesser‐Robelet, Mylène Duplan, Isabelle Pellier, Delphine Bourneau‐Martin, Séverine Derbré   +6 more
wiley   +1 more source

Design principles and therapeutic applications of novel synthetic WNT signaling agonists

iScience
Summary: Wingless-related integration site or Wingless and Int-1 or Wingless-Int (WNT) signaling is crucial for embryonic development, and adult tissue homeostasis and regeneration, through its essential roles in cell fate, patterning, and stem cell ...
Yorick Post, Chenggang Lu, Russell B. Fletcher, Wen-Chen Yeh, Huy Nguyen, Sung-Jin Lee, Yang Li   +6 more
doaj   +1 more source

NanoLuc reporters identify COL4A5 nonsense mutations susceptible to drug-induced stop codon readthrough

iScience, 2022
Summary: Alport syndrome, a disease of kidney, ear, and eye, is caused by pathogenic variants in the COL4A3, COL4A4, or COL4A5 genes encoding collagen α3α4α5(IV) of basement membranes.
Kohei Omachi, Hirofumi Kai, Michel Roberge, Jeffrey H. Miner   +3 more
doaj   +1 more source

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source

Harnessing Homalomena aromatica for green synthesis of AgNPs and unveiling therapeutic antioxidant and antibacterial activities

Green Chemistry Letters and Reviews
Green synthesis of silver nanoparticles (AgNPs) using Homalomena aromatica leaf extract as a reducing agent has garnered interest due to its eco-friendly nature and broad applications, particularly in molecular medicine.
Dipan Sarma, Badal K. Datta, Kuldip Gosai, Taha Alqahtani, Arabinda Ghosh, Daniel Ejim Uti   +5 more
doaj   +1 more source

Activation of GDNF-ERK-Runx1 signaling contributes to P2X3R gene transcription and bone cancer pain

iScience, 2022
Summary: Bone cancer pain is a common symptom in cancer patients with bone metastases and its underlying mechanisms remain unknown. Here, we report that Runx1 directly upregulates the transcriptional activity of P2X3 receptor (P2X3R) gene promoter in ...
Zhu-Lin Yuan, Xiao-Dan Liu, Zi-Xian Zhang, Song Li, Yue Tian, Ke Xi, Jie Cai, Xiao-Mei Yang, Min Liu, Guo-Gang Xing   +9 more
doaj   +1 more source