Results 41 to 50 of about 3,444,468 (295)

Label-free approaches for extracellular vesicle detection

iScience, 2023
Summary: Extracellular vesicles (EVs) represent pivotal mediators in cell-to-cell communication. They are lipid-membranous carriers of several biomolecules, which can be produced by almost all cells.
Loredana Leggio, Greta Paternò, Silvia Vivarelli, Aurelio Bonasera, Bruno Pignataro, Nunzio Iraci, Giuseppe Arrabito   +6 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Revolutionizing Healthcare: The Proteomics Paradigm in Molecular Medicine

Pakistan Journal of Medicine and Dentistry
Proteomics, the comprehensive study of function, composition, structures, and interactions of proteins in biological systems, has emerged as a revolutionary force in the field of molecular medicine.
Yamna Khurshid
doaj   +1 more source

NanoLuc reporters identify COL4A5 nonsense mutations susceptible to drug-induced stop codon readthrough

iScience, 2022
Summary: Alport syndrome, a disease of kidney, ear, and eye, is caused by pathogenic variants in the COL4A3, COL4A4, or COL4A5 genes encoding collagen α3α4α5(IV) of basement membranes.
Kohei Omachi, Hirofumi Kai, Michel Roberge, Jeffrey H. Miner   +3 more
doaj   +1 more source

Medical treatment of early stage and rare histological variants of epithelial ovarian cancer [PDF]

, 2015
Epithelial ovarian cancer is often considered a single pathological entity, but increasing evidence suggests that it is rather a group of different neoplasms, each with unique pathological characteristics, molecular features, and clinical behaviours ...
Biglia, Nicoletta, CODACCI PISANELLI, Giovanni, Colombo, Nicoletta, Cont, Nicoletta Tomasi, D'Alonzo, Marta, Ferrero, Annamaria, Peccatori, Fedro Alessandro   +6 more
core   +3 more sources

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Research Advances in Adenomyosis-Related Signaling Pathways and Promising Targets

Biomolecules
Adenomyosis is a benign gynecological condition characterized by the proliferation of the endometrial stroma and glands into the myometrium, uterine volume enlargement, and peripheral smooth muscle hypertrophy.
Hongyu Zhang, Chaoming Li, Wenyan Li, Wenhu Xin, Tiansheng Qin   +4 more
doaj   +1 more source

Activation of GDNF-ERK-Runx1 signaling contributes to P2X3R gene transcription and bone cancer pain

iScience, 2022
Summary: Bone cancer pain is a common symptom in cancer patients with bone metastases and its underlying mechanisms remain unknown. Here, we report that Runx1 directly upregulates the transcriptional activity of P2X3 receptor (P2X3R) gene promoter in ...
Zhu-Lin Yuan, Xiao-Dan Liu, Zi-Xian Zhang, Song Li, Yue Tian, Ke Xi, Jie Cai, Xiao-Mei Yang, Min Liu, Guo-Gang Xing   +9 more
doaj   +1 more source

The future of laboratory medicine - A 2014 perspective. [PDF]

, 2015
Predicting the future is a difficult task. Not surprisingly, there are many examples and assumptions that have proved to be wrong. This review surveys the many predictions, beginning in 1887, about the future of laboratory medicine and its sub ...
FORTINA, PAOLO, Kricka LJ, Park JY, Polsky TG   +3 more
core   +1 more source

Design principles and therapeutic applications of novel synthetic WNT signaling agonists

iScience
Summary: Wingless-related integration site or Wingless and Int-1 or Wingless-Int (WNT) signaling is crucial for embryonic development, and adult tissue homeostasis and regeneration, through its essential roles in cell fate, patterning, and stem cell ...
Yorick Post, Chenggang Lu, Russell B. Fletcher, Wen-Chen Yeh, Huy Nguyen, Sung-Jin Lee, Yang Li   +6 more
doaj   +1 more source