Empowering precision medicine through high performance computing clusters [PDF]
, 2018 The role of High Performance Computing (HPC) in Medicine is greatly increase in these last years, moving from basic research to the clinics. With the advent of Next Generation Sequencing (NGS) technologies, diverse areas of human health have been ...
Castrignanò Tiziana +2 more
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Molecular medicine of microRNAs: structure, function and implications for diabetes [PDF]
, 2008 MicroRNAs (miRNAs) are a family of endogenous small noncoding RNA molecules, of 19–28 nucleotides in length. In humans, up to 3% of all genes are estimated to encode these evolutionarily conserved sequences.
Duncan +5 more
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Suppressing nonsense--a surprising function for 5-azacytidine. [PDF]
, 2014 In this issue of EMBO Molecular Medicine, Bhuvanagiri et al report on a chemical means to convert molecular junk into gold. They identify a chemical inhibitor of a quality control pathway that is best known for its ability to clear cells of rubbish, but ...
Shao, Ada, Wilkinson, Miles F
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Mechanisms of CFTR Functional Variants That Impair Regulated Bicarbonate Permeation and Increase Risk for Pancreatitis but Not for Cystic Fibrosis [PDF]
, 2014 CFTR is a dynamically regulated anion channel. Intracellular WNK1-SPAK activation causes CFTR to change permeability and conductance characteristics from a chloride-preferring to bicarbonate-preferring channel through unknown mechanisms.
Alkaade, Samer +26 more
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TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling [PDF]
, 2013 In patients, non-proliferative disseminated tumour cells (DTCs) can persist in the bone marrow (BM) while other organs (such as lung) present growing metastasis.
Aguirre Ghiso, Julio A. +7 more
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Culin5 aggravates hypoxic pulmonary hypertension by activating TRAF6/NF-κB/HIF-1α/VEGF
iScience, 2023 Summary: Hypoxic pulmonary hypertension (HPH) lacks effective pharmacologic treatments. Microarray-based gene expression indicates the crucial role of Cullin 5 (Cul 5) in HPH.
Lei Wang +10 more
doaj +1 more source
Antidiabetic effect of Tibetan medicine Tang-Kang-Fu-San in db/db mice via activation of PI3K/Akt and AMPK pathways [PDF]
, 2017 This study was to investigate the anti-diabetic effects and molecular mechanisms of Tang-Kang-Fu-San (TKFS), a traditional Tibetan medicine, in treating type 2 diabetes mellitus of spontaneous diabetic db/db mice.
Bailu Duan +8 more
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The Master Observational Trial: A New Class of Master Protocol to Advance Precision Medicine. [PDF]
, 2020 This commentary introduces a new clinical trial construct, the Master Observational Trial (MOT), which hybridizes the power of molecularly based master interventional protocols with the breadth of real-world data.
Bergan, Raymond +5 more
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High-throughput screening in larval zebrafish identifies novel potent sedative-hypnotics [PDF]
, 2018 BACKGROUND: Many general anesthetics were discovered empirically, but primary screens to find new sedative-hypnotics in drug libraries have not used animals, limiting the types of drugs discovered.
Brown, Lauren E. +12 more
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E. I. SHWARTZ: AT THE ORIGINS OF MOLECULAR MEDICINE
Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2020 Eugene I. Schwartz (1940–2003), the first head of the Department of Molecular Genetic Technologies of the Research Center of the Pavlov University, a well-known geneticist, stood at the origins of molecular medicine in Russia. The results of the research
S. N. Pchelina
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