Results 11 to 20 of about 3,444,468 (295)

Biomarkers in renal cell carcinoma and their targeted therapies: a review

Exploration of Targeted Anti-tumor Therapy, 2023
Renal cell carcinoma (RCC) is one of the most life-threatening urinary malignancies displaying poor response to radiotherapy and chemotherapy. Although in the recent past there have been tremendous advancements in using targeted therapies for RCC ...
Shruti Gupta, Shamsher Singh Kanwar
doaj   +1 more source

Mutasi gen KRAS pada kanker kolorektal

Majalah Kedokteran Andalas, 2021
Onkogen RAS memiliki peran dalam pertumbuhan dan regulasi sel. Protein ini mempengaruhi banyak fungsi seluler termasuk proliferasi sel, diferensiasi, dan apoptosis. Jika KRAS mengalami mutasi, maka KRAS secara konstitutif akan tetap dalam keadaan terikat
Ni Nyoman Ayu Dewi, Anak Agung Ngurah Satya Pranata, Ni Made Pramita Widya Suksmarini   +2 more
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Introduction to Neurodevelopmental Disorders [PDF]

Annals of Child Neurology
Neurodevelopmental disorders (NDDs) comprise a heterogeneous group of conditions characterized by impairments in cognition, language, motor function, behavior, and social communication that originate during the developmental period.
Baik-Lin Eun, Hee Jung Chung
doaj   +1 more source

Dissecting the impact of target-binding kinetics of protein binders on tumor localization

iScience, 2021
Summary: Systematic control of in vivo behavior of protein-based therapeutics is considered highly desirable for improving their clinical outcomes. Modulation of biochemical properties including molecular weight, surface charge, and binding affinity has ...
Yunjin Song, Hoibin Jeong, Song-Rae Kim, Yiseul Ryu, Jonghwi Baek, Jinhak Kwon, Hyeongjun Cho, Kil-Nam Kim, Joong-jae Lee   +8 more
doaj   +1 more source

Patient-centric trials for therapeutic development in precision oncology [PDF]

, 2015
An enhanced understanding of the molecular pathology of disease gained from genomic studies is facilitating the development of treatments that target discrete molecular subclasses of tumours.
A Hollebecque, A-M Tsimberidou, AD Barker, AL Tam, Andrew V. Biankin, AT Shaw, AV Biankin, B Zhang, C Le Tourneau, C Le Tourneau, C Lin, C Printz, CK Lee, CR Lindsay, D Cook, D Slamon, D Zardavas, DD Von Hoff, DE Gerber, DJ Sargent, DT Le, EA Eisenhauer, ED Green, ES Kim, F André, GD Demetri, GM Frampton, IR Watson, J Ledermann, J Lewin, J Verweij, JA Sosman, JY Douillard, L Chin, L Chin, L Seguin, LA Chantrill, LB Alexandrov, LJ Esserman, LJ Esserman, M Hay, M Maemondo, MG Kris, MR Stratton, MR Stratton, N Roper, N Waddell, NM Hylton, PA Jänne, PN Lara Jr, R Dienstmann, R Simon, RR Kalf, S Matsumoto, S Sleijfer, Simon J. Hollingsworth, SJ Dawson, SJ Mandrekar, Steven Piantadosi, TA Yap, TJ Hudson   +60 more
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Loss of Ciliary Gene Bbs8 Results in Physiological Defects in the Retinal Pigment Epithelium

Frontiers in Cell and Developmental Biology, 2021
Primary cilia are sensory organelles vital for developmental and physiological processes. Their dysfunction causes a range of phenotypes including retinopathies.
Sandra Schneider, Rossella De Cegli, Jayapriya Nagarajan, Viola Kretschmer, Peter Andreas Matthiessen, Daniela Intartaglia, Nathan Hotaling, Marius Ueffing, Karsten Boldt, Ivan Conte, Ivan Conte, Helen Louise May-Simera   +11 more
doaj   +1 more source

Clinical proteomics for precision medicine: the bladder cancer case [PDF]

, 2017
Precision medicine can improve patient management by guiding therapeutic decision based on molecular characteristics. The concept has been extensively addressed through the application of –omics based approaches.
Frantzi, Maria, Latosinska, Agnieszka, Merseburger, Axel S., Mischak, Harald, Vlahou, Antonia   +4 more
core   +1 more source

Spicy science: David Julius and the discovery of temperature-sensitive TRP channels. [PDF]

, 2015
This invited biographical review covers the career of Dr. David Julius and his discovery of thermosensitive TRP channels. Dr. Julius is currently the Morris Herzstein Chair in Molecular Biology and Medicine and Professor and Chair of Physiology at the ...
Bautista, Diana
core   +2 more sources

Clinical applications of personalized medicine: a new paradigm and challenge [PDF]

, 2017
The personalized medicine is an emergent and rapidly developing method of clinical practice that uses new technologies to provide decisions in regard to the prediction, prevention, diagnosis and treatment of disease.
Borro, Marina, DI SANZO, Mariantonia, Fineschi, Vittorio, Frati, Paola, LA RUSSA, Raffaele, Santurro, Alessandro, Scopetti, Matteo, Simmaco, Maurizio   +7 more
core   +1 more source

Genomic and proteomic approaches for studying human cancer: Prospects for true patient-tailored therapy

Human Genomics, 2004
Global gene expression analysis is beginning to move from the laboratories of basic investigators to large-scale clinical trials. The potential of this technology to improve diagnosis and tailored treatment of human disease may soon be realised, now that
Carr Kristen M, Rosenblatt Kevin, Petricoin Emanuel F, Liotta Lance A   +3 more
doaj   +1 more source