Results 11 to 20 of about 2,276,422 (251)

Biomarkers in renal cell carcinoma and their targeted therapies: a review

Exploration of Targeted Anti-tumor Therapy, 2023
Renal cell carcinoma (RCC) is one of the most life-threatening urinary malignancies displaying poor response to radiotherapy and chemotherapy. Although in the recent past there have been tremendous advancements in using targeted therapies for RCC ...
Shruti Gupta, Shamsher Singh Kanwar
doaj   +1 more source

Mutasi gen KRAS pada kanker kolorektal

Majalah Kedokteran Andalas, 2021
Onkogen RAS memiliki peran dalam pertumbuhan dan regulasi sel. Protein ini mempengaruhi banyak fungsi seluler termasuk proliferasi sel, diferensiasi, dan apoptosis. Jika KRAS mengalami mutasi, maka KRAS secara konstitutif akan tetap dalam keadaan terikat
Ni Nyoman Ayu Dewi, Anak Agung Ngurah Satya Pranata, Ni Made Pramita Widya Suksmarini   +2 more
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Introduction to Neurodevelopmental Disorders [PDF]

Annals of Child Neurology
Neurodevelopmental disorders (NDDs) comprise a heterogeneous group of conditions characterized by impairments in cognition, language, motor function, behavior, and social communication that originate during the developmental period.
Baik-Lin Eun, Hee Jung Chung
doaj   +1 more source

Dissecting the impact of target-binding kinetics of protein binders on tumor localization

iScience, 2021
Summary: Systematic control of in vivo behavior of protein-based therapeutics is considered highly desirable for improving their clinical outcomes. Modulation of biochemical properties including molecular weight, surface charge, and binding affinity has ...
Yunjin Song, Hoibin Jeong, Song-Rae Kim, Yiseul Ryu, Jonghwi Baek, Jinhak Kwon, Hyeongjun Cho, Kil-Nam Kim, Joong-jae Lee   +8 more
doaj   +1 more source

Loss of Ciliary Gene Bbs8 Results in Physiological Defects in the Retinal Pigment Epithelium

Frontiers in Cell and Developmental Biology, 2021
Primary cilia are sensory organelles vital for developmental and physiological processes. Their dysfunction causes a range of phenotypes including retinopathies.
Sandra Schneider, Rossella De Cegli, Jayapriya Nagarajan, Viola Kretschmer, Peter Andreas Matthiessen, Daniela Intartaglia, Nathan Hotaling, Marius Ueffing, Karsten Boldt, Ivan Conte, Ivan Conte, Helen Louise May-Simera   +11 more
doaj   +1 more source

Genomic and proteomic approaches for studying human cancer: Prospects for true patient-tailored therapy

Human Genomics, 2004
Global gene expression analysis is beginning to move from the laboratories of basic investigators to large-scale clinical trials. The potential of this technology to improve diagnosis and tailored treatment of human disease may soon be realised, now that
Carr Kristen M, Rosenblatt Kevin, Petricoin Emanuel F, Liotta Lance A   +3 more
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Culin5 aggravates hypoxic pulmonary hypertension by activating TRAF6/NF-κB/HIF-1α/VEGF

iScience, 2023
Summary: Hypoxic pulmonary hypertension (HPH) lacks effective pharmacologic treatments. Microarray-based gene expression indicates the crucial role of Cullin 5 (Cul 5) in HPH.
Lei Wang, Jing Huang, Ruoyang Zhang, Muzhi Zhang, Yu Guo, Yang Liu, Cong Li, Wei Wang, Sun Ying, Jie Liu, Chen Wang   +10 more
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Molecular medicine in development [PDF]

Nature, 1995
The case for modernizing the practice of medicine in the developing countries of the world is strong and also irresistible, but the mechanisms for doing that need to be improved.
openaire   +2 more sources

Role of Hypoxia Induced by Medicinal Plants; A Revolutionary Era of Cellular and Molecular Herbal Medicine in Neuroblastoma Treatment

Frontiers in Bioscience-Landmark
As one of the most common solid pediatric cancers, Neuroblastoma (NBL) accounts for 15% of all of the cancer-related mortalities in infants with increasing incidence all around the world.
Samin Rahimi, Fatemeh Shirin, Mahdi Moassesfar, Hossein Zafari, Nazila Bahmaie, Kimia Baghebani, Yasna Bidmeshki, Seyede Masoumeh Sajjadi Manesh, Kasra Rasoulzadeh Darabad, Massoud Bahmaie, Elham Nouri, Ahmet Kilic, Melika Ansarin, Pınar Özışık, Ender Simsek, Ozen Ozensoy Guler   +15 more
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Exosome Nanotechnology in Molecular Medicine: Advances, Applications and Challenges in Gene Therapy

Expert Reviews in Molecular Medicine
Background Gene therapy has emerged as a transformative approach for treating diseases that are caused by genetic defects, including cancer, inherited metabolic disorders and immunodeficiencies.
Elza Karabagh, Babek Alibayov, Adil Allahverdiyev   +2 more
doaj   +1 more source