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Molecular Mimicry in Multiple Sclerosis
New England Journal of Medicine, 2003Molecular mimicry is a model in which foreign antigens are sufficiently similar to native antigens to trigger an autoimmune response. A study involving the specificity of a T-cell receptor derived from a patient with multiple sclerosis indicates that molecular mimicry extends to complexes of proteins — a finding with implications for therapy.
Wekerle, H., Hohlfeld, R.
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Parasitology Today, 1987
The host immune response is an important line of defence against parasites. Tactics to evade this response are therefore expected in host-parasite relationships, and the clearest example is the antigenic variation displayed by African trypanosomes. But while few other parasites seem to have quite this ability, many seem to display a form of antigenic ...
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The host immune response is an important line of defence against parasites. Tactics to evade this response are therefore expected in host-parasite relationships, and the clearest example is the antigenic variation displayed by African trypanosomes. But while few other parasites seem to have quite this ability, many seem to display a form of antigenic ...
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Molecular mimicry or structural mimicry?
Molecular Immunology, 2006"Molecular mimicry" should be changed to "structural mimicry". The immune system recognizes shapes--three-dimensional shapes--not sequences. For two sequences to act biologically similar they must possess similar three-dimensional structures.
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Microbial Pathogenesis, 2020
Pathogens and humans share an intrinsic relation related to molecular mimicry in their antigens. Interactions between immune system and pathogenic antigens result in a production of antibodies that could protect against infection, but develop ...
M. Múnera +7 more
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Pathogens and humans share an intrinsic relation related to molecular mimicry in their antigens. Interactions between immune system and pathogenic antigens result in a production of antibodies that could protect against infection, but develop ...
M. Múnera +7 more
semanticscholar +1 more source
Chemokine receptors and molecular mimicry
Immunology Today, 1994Chemokines are small pro-inflammatory peptides that are best known for their leukocyte-chemoattractant activity. The cloned leukocyte chemokine receptors, interleukin 8 receptor (IL-8R) types A and B and the macrophage inflammatory protein 1 alpha (MIP-1 alpha)/RANTES receptor, are related by sequence and chemokine binding to two herpesvirus products ...
S K, Ahuja, J L, Gao, P M, Murphy
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Molecular mimicry and auto-immunity
Clinical Reviews in Allergy & Immunology, 2007The term "molecular mimicry" was coined by R. Damian in 1964, who was first to suggest that antigenic determinants of micro-organisms may resemble antigenic determinants of their host. Damian suggested that this similarity served as a defense mechanism of a microorganism from the host's immune system and prevented the development of immune response to ...
Miri, Blank +2 more
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Tropomyosin and molecular mimicry
Parasitology Today, 1991cyst investiture in nonmuscle tropo- myosin may play a role in immune evasion in the snail host by protecting the sporocyst from amoebocyte attack. If true, this would be a prime example of molecular mimicry in its full and original sense s , which links common structures to the host-parasite relationship.
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Molecular Mimicry in Mercury Toxicology
Chemical Research in Toxicology, 2006Molecular mimicry occurs when one molecular entity is "mistaken" for another by cellular or other biological processes, and is thought to arise from structural similarities between the two molecules in question. It has been postulated by others to be important in the mechanism of uptake of toxic metal species into living tissues.
Hoffmeyer, R. +6 more
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Molecular Mimicry and Diabetes
1989Insulin-dependent diabetes (IDDM) often develops early in life and is associated with lifelong insulin treatment, a reduced life span, and serious long-term complications (Borch-Johnsen et al. 1986). Other forms of diabetes exist (National Diabetes Data Group 1979), e.g., noninsulin-dependent diabetes, maturity onset diabetes in the young (MODY), and ...
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