Results 61 to 70 of about 3,780,564 (348)

miPepBase: A Database of Experimentally Verified Peptides Involved in Molecular Mimicry

Frontiers in Microbiology, 2017
Autoimmune diseases emerge due to several reasons, of which molecular mimicry i.e., similarity between the host's and pathogen's interacting peptides is an important reason. In the present study we have reported a database of only experimentally verified
Anjali Garg, Bandana Kumari, Ravindra Kumar, Manish Kumar   +3 more
doaj   +1 more source

Architecturally diverse proteins converge on an analogous mechanism to inactivate Uracil-DNA glycosylase [PDF]

, 2013
Uracil-DNA glycosylase (UDG) compromises the replication strategies of diverse viruses from unrelated lineages. Virally encoded proteins therefore exist to limit, inhibit or target UDG activity for proteolysis.
A. R. Cole, Acharya, Barrett, Berkner, Broennimann, dos Reis, Duncan, Emsley, Freitag, G. Baltulionis, Haushalter, Hennessy, Huang, Jern, K. Ryzhenkova, Kabsch, Katz, Kiljunen, Kleywegt, Koulis, Martomo, McCoy, Newman, P. Hornyak, Pearl, Perez-Lago, Putnam, Putnam, R. Savva, S. Ofer, Savva, Savva, Savva, Schorman, Sharp, Takahashi, Tye, Warner, Warren, Winn   +39 more
core   +1 more source

Lack of Evidence for Molecular Mimicry in HIV-Infected Subjects. [PDF]

PLoS ONE, 2015
Previous studies in HIV patients have reported autoantibodies to several human proteins, including erythropoietin (EPO), interferon-α (IFN-α), interleukin-2 (IL-2), and HLA-DR, as potential mediators of anemia or immunosuppression.
Peter D Burbelo, James S Klimavicz, Steve G Deeks, Joseph A Kovacs, Jack A Ragheb   +4 more
doaj   +1 more source

From Anti-SARS-CoV-2 Immune Responses to COVID-19 via Molecular Mimicry

Antibodies, 2020
Aim: To define the autoimmune potential of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Methods: Experimentally validated epitopes cataloged at the Immune Epitope DataBase (IEDB) and present in SARS-CoV-2 were analyzed for ...
D. Kanduc
semanticscholar   +1 more source

Immobilization by surface conjugation of cyclic peptides for effective mimicry of the HCV-envelope E2 protein as a strategy toward synthetic vaccines [PDF]

, 2018
Mimicry of the binding interface of antibody-antigen interactions using peptide-based modulators (i.e. epitope mimics) has promising applications for vaccine design.
Dunlop, James I., Liskamp, Rob M.J., Meuleman, Theodorus J., Owsianka, Anna M., Patel, Arvind H., van de Langemheen, Helmus   +5 more
core   +2 more sources

The Gut Microbiome in Neuromyelitis Optica. [PDF]

, 2017
Neuromyelitis optica (NMO) is a rare, disabling, sometimes fatal central nervous system inflammatory demyelinating disease that is associated with antibodies ("NMO IgG") that target the water channel protein aquaporin-4 (AQP4) expressed on astrocytes ...
Baranzini, Sergio E, Cree, Bruce AC, Spencer, Collin M, Zamvil, Scott S   +3 more
core   +1 more source

Guillain-Barré syndrome: a century of progress [PDF]

, 2016
In 1916, Guillain, Barré and Strohl reported on two cases of acute flaccid paralysis with high cerebrospinal fluid protein levels and normal cell counts — novel findings that identified the disease we now know as Guillain–Barré syndrome (GBS).
A Campbell, A Chiba, A Chiba, A Pestronk, A Uncini, AA Ilyas, AD Langmuir, AJ Sumner, AK Asbury, AK Asbury, AK Asbury, AM Fitzpatrick, B Parra, B van den Berg, BH Waksman, C Brechenmacher, C Fokke, C Hafer-Macko, C Linington, CE Hafer-Macko, CL Schengrund, CP O'Leary, E Díez-Tejedor, FG van der Meché, FH Geisler, G Guillain, GM McKhann, GM O'Hanlon, H Wis´niewski, HJ Willison, Hugh J. Willison, J Kaldor, J Matias-Guiu, JA Goodfellow, JC Dodge, JG McLeod, JH Rees, JJ Plomp, JM Pearce, John A. Goodfellow, JW Albers, JW Griffin, JW Prineas, K Kaida, K Susuki, KE Astrom, KM Rhodes, KN Greenshields, LB Schonberger, LD Osler, LM Araujo, LT Kurland, M Fisher, M Kadlubowski, M Vermeulen, MK White, N Shahrizaila, N Yuki, N Yuki, N Yuki, N Yuki, NA Gregson, O Landry, PA van Doorn, PO Osterman, R McGonigal, R McGonigal, R van Koningsveld, RA Hughes, RA Hughes, RJ Greenwood, RP Kleyweg, S Draganescu, S Kusunoki, S Lafontaine, S Rinaldi, S Rinaldi, S Rinaldi, SK Halstead, SK Halstead, SK Halstead, T Lasky, T Saida, TE Feasby, TE Feasby, TW Ho, TW Ho, VM Cao-Lormeau, W Wiederholt, W Yan, WE Haymaker, Y Nagai   +91 more
core   +1 more source

Autoimmunity and molecular mimicry in tropical spastic paraparesis/human T-lymphotropic virus-associated myelopathy

Brazilian Journal of Medical and Biological Research, 2005
Viruses share antigenic sites with normal host cell components, a phenomenon known as molecular mimicry. It has long been suggested that viral infections might trigger an autoimmune response by several mechanisms including molecular mimicry.
F. García-Vallejo, M.C. Domínguez, O. Tamayo   +2 more
doaj   +1 more source

BNIP3 supports melanoma cell migration and vasculogenic mimicry by orchestrating the actin cytoskeleton [PDF]

, 2014
BNIP3 is an atypical BH3-only member of the BCL-2 family of proteins with reported pro-death as well as pro-autophagic and cytoprotective functions, depending on the type of stress and cellular context.
Agostinis, P, Garg, AD, Krysko, Dmitri, Maes, H, Nys, K, Rillaerts, K, Van Eygen, S, Vandenabeele, Peter, Verfaillie, T   +8 more
core   +2 more sources

Benchmarking evolutionary tinkering underlying human–viral molecular mimicry shows multiple host pulmonary–arterial peptides mimicked by SARS-CoV-2

Cell Death Discovery, 2020
The hand of molecular mimicry in shaping SARS-CoV-2 evolution and immune evasion remains to be deciphered. Here, we report 33 distinct 8-mer/9-mer peptides that are identical between SARS-CoV-2 and the human reference proteome.
A. Venkatakrishnan, N. Kayal, Praveen Anand, A. Badley, G. Church, V. Soundararajan   +5 more
semanticscholar   +1 more source