Results 71 to 80 of about 368,707 (256)

Electrical stimulation counteracts muscle atrophy associated with aging in humans

European Journal of Translational Myology, 2013
Functional and structural muscle decline is a major problem during aging. Our goal was to improve in old subjects quadriceps m. force and mobility functional performances (stair test, chair rise test, timed up and go test) with neuromuscular electrical ...
Helmut Kern, Stefan Loefler, Samantha Burggraf, Hannah Fruhmann, Jan Cvecka, Milan Sedliak, Laura Barberi, Manuela De Rossi, Antonio Musarò, Ugo Carraro, Simone Mosole, Sandra Zampieri   +11 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

High mobility group box 1 in the central nervous system: regeneration hidden beneath inflammation

Neural Regeneration Research
High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields, including neurology and neuroscience.
Hanki Kim, Bum Jun Kim, Seungyon Koh, Hyo Jin Cho, Xuelian Jin, Byung Gon Kim, Jun Young Choi   +6 more
doaj   +1 more source

Genuine antiplasticizing effect of water on a glass-former drug

Scientific Reports, 2017
Water is the most important plasticizer of biological and organic hydrophilic materials, which generally exhibit enhanced mechanical softness and molecular mobility upon hydration.
Guadalupe N. Ruiz, Michela Romanini, Astrid Hauptmann, Thomas Loerting, Evgenyi Shalaev, Josep Ll. Tamarit, Luis C. Pardo, Roberto Macovez   +7 more
doaj   +1 more source

Molecular Dynamics Calculations of Grain Boundary Mobility in CdTe

Nanomaterials, 2019
Molecular dynamics (MD) simulations have been applied to study mobilities of Σ3, Σ7 and Σ11 grain boundaries in CdTe. First, an existing MD approach to drive the motion of grain boundaries in face-centered-cubic and body-centered-cubic ...
Rodolfo Aguirre, Sharmin Abdullah, Xiaowang Zhou, David Zubia   +3 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Suppressing molecular vibrations in organic semiconductors by inducing strain

Nature Communications, 2016
The mobility of organic semiconductors can be tuned by modifying their chemical composition or crystalline properties. Here, the authors show that bending organic single crystals increases their field effect transistor mobility due to restrained ...
Takayoshi Kubo, Roger Häusermann, Junto Tsurumi, Junshi Soeda, Yugo Okada, Yu Yamashita, Norihisa Akamatsu, Atsushi Shishido, Chikahiko Mitsui, Toshihiro Okamoto, Susumu Yanagisawa, Hiroyuki Matsui, Jun Takeya   +12 more
doaj   +1 more source

Molecular Mobility in Keratin-Rich Materials Monitored by Nuclear Magnetic Resonance: A Tool for the Evaluation of Structure-Giving Properties. [PDF]

Biomacromolecules, 2023
Gunnarsson M, Larsson S, Malak M, Ericson MB, Topgaard D, Sparr E.   +5 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source