Influence of Neutralization Precipitation Conditions on the Physical Stability of Amorphous Solid Pharmaceuticals [PDF]
MoleculesThis research focused on the precipitation of amorphous forms of nilotinib with high physical stability through the manipulation of various parameters in the neutralization reaction, specifically the quantity of nilotinib, the pH value, and the ...
Zhihui Yuan +4 more
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High-Pressure Dielectric Spectroscopic Studies of Amorphous CBD: Investigating Molecular Dynamics and Physical Stability Under Manufacturing Conditions of the Pharmaceuticals [PDF]
PharmaceuticsObjectives: This study highlighted the key role played by high-pressure (HP) dielectric spectroscopic measurements of amorphous CBD to probe the molecular dynamics in order to examine the physical stability of the drug.
Mariya Mathew +3 more
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Invariant representation of physical stability in the human brain [PDF]
eLife, 2022 Successful engagement with the world requires the ability to predict what will happen next. Here, we investigate how the brain makes a fundamental prediction about the physical world: whether the situation in front of us is stable, and hence likely to ...
RT Pramod +3 more
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Investigation of the Influence of Anti-Solvent Precipitation Parameters on the Physical Stability of Amorphous Solids [PDF]
MoleculesAmorphous solids exhibit enhanced solubility and dissolution rates relative to their crystalline counterparts. However, attaining optimal bioavailability presents a challenge, primarily due to the need to maintain the physical stability of amorphous ...
Zunhua Li +3 more
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Ternary Solid Dispersions: A Review of the Preparation, Characterization, Mechanism of Drug Release, and Physical Stability [PDF]
Pharmaceutics, 2023 The prevalence of active pharmaceutical ingredients (APIs) with low water solubility has experienced a significant increase in recent years. These APIs present challenges in formulation, particularly for oral dosage forms, despite their considerable ...
Arif Budiman +8 more
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Pharmaceutics, 2022 Amorphous solid dispersions stabilized by one or more polymer(s) have been widely used for delivering amorphous drugs with poor water solubilities, and they have gained great market success.
Qin Shi +5 more
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Nanosuspensions Loaded with Acetogenins: Physical Stability During In Vitro Digestion, Genotoxicity and Cytotoxicity [PDF]
FoodsThis study assesses the stability, in vitro bioaccessibility and potential bioavailability, and in vivo genotoxicity and toxicity of polyethylene glycol–soy lecithin (PEGSL-ACG-NSps) or β-cyclodextrin–soy lecithin (βCDSL-ACG-NSps) nanosuspensions (NSps).
Brandon Alexis López-Romero +5 more
doaj +2 more sources
The effect of sucrose palmitate characteristics as a surfactant on the physical stability of red palm oil submicroemulsions [PDF]
Journal of Advanced Pharmaceutical Technology & ResearchSubmicroemulsions are delivery systems that can enhance the solubility and stability of lipophilic compounds, such as red palm oil (RPO). This study aimed to evaluate the effects of sucrose palmitate (surfactant) on the characteristics and stability of ...
Elsa Fitria Apriani +3 more
doaj +2 more sources
Two in One: Size Characterization and Accelerated Short-Term Physical Stability of Dual-Drug Suspensions with Two Acidic Compounds (Indomethacin and Naproxen) [PDF]
PharmaceuticsBackground/Objectives: Co-delivering dual-drug systems have proven to be effective in, for example, anticancer therapy or HIV prophylaxis due to a higher target selectivity and therapeutic efficacy from compound synergism.
Nadina Zulbeari +2 more
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ADMET and DMPK, 2023 Background and purpose: Physicochemical properties of an amorphous solid dispersion (ASD) comprising an experimental grade of hydroxypropyl methylcellulose acetate succinate (HPMCAS-MX) with lower glass transition temperature have been previously ...
Hironori Tanaka +2 more
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