Results 1 to 10 of about 1,873,271 (247)

Cellulose based polymers in development of amorphous solid dispersions

Asian Journal of Pharmaceutical Sciences, 2019
Cellulose derivatives have gained immense popularity as stabilizers for amorphous solid dispersion owing to their diverse physicochemical properties. More than 20 amorphous solid dispersion-based products that have been approved for marketing consist of ...
Rahul B Chavan, Sneha Rathi, Vaskuri G S Sainaga Jyothi, Nalini R Shastri   +3 more
doaj   +2 more sources

Manufacturing Different Types of Solid Dispersions of BCS Class IV Polyphenol (Daidzein) by Spray Drying: Formulation and Bioavailability

Pharmaceutics, 2019
Daidzein (DZ) is a polyphenolic compound belonging to Biopharmaceutical Classification System class IV, which shows that it may have limited therapeutic effects due to its low solubility and poor bioavailability. This study aimed to obtain high-purity DZ
Gean Pier Panizzon, Fernanda Giacomini Bueno, Tânia Ueda-Nakamura, Celso Vataru Nakamura, Benedito Prado Dias Filho   +4 more
doaj   +1 more source

Investigating the Influence of Processing Conditions on Dissolution and Physical Stability of Solid Dispersions with Fenofibrate and Mesoporous Silica

Pharmaceutics
The study aimed to enhance the solubility of the poorly water-soluble drug, fenofibrate, by loading it onto mesoporous silica, forming amorphous solid dispersions.
Ana Baumgartner, Nina Dobaj, Odon Planinšek   +2 more
doaj   +1 more source

Micro-Injection Moulding of Poly(vinylpyrrolidone-vinyl acetate) Binary and Ternary Amorphous Solid Dispersions

Pharmaceutics, 2019
Micro-injection moulding (µIM) was used for the production of enteric tablets of plasticised and unplasticised solid dispersions of poly(vinylpyrrolidone-vinyl acetate) (PVPVA), and the effect of the mechanical and thermal treatment on the ...
Romina Pezzoli, Michael Hopkins Jnr, Guillaume Direur, Noel Gately, John G. Lyons, Clement L. Higginbotham   +5 more
doaj   +1 more source

Molecular Interactions for the Curcumin-Polymer Complex with Enhanced Anti-Inflammatory Effects

Pharmaceutics, 2019
The molecular interactions between compound and polymeric carriers are expected to highly contribute to high drug load and good physical stability of solid dispersions.
Yan He, Hongfei Liu, Wangqing Bian, Yue Liu, Xinyang Liu, Shijing Ma, Xi Zheng, Zhiyun Du, Kun Zhang, Defang Ouyang   +9 more
doaj   +1 more source

Study of gliclazide solid dispersion systems using PVP K-30 and PEG 6000 by solvent method

Journal of Pharmacy and Bioallied Sciences, 2019
Gliclazide is a second-generation hypoglycemic sulfonylurea, which is useful in the treatment of non-insulin-dependent diabetes mellitus. It has low bioavailability because of its limited water solubility and slow dissolution rate.
Febriyenti Febriyenti, Suraiya Rahmi, Auzal Halim   +2 more
doaj   +1 more source

Application of the Box–Behnken Design in the Development of Amorphous PVP K30–Phosphatidylcholine Dispersions for the Co-Delivery of Curcumin and Hesperetin Prepared by Hot-Melt Extrusion

Pharmaceutics
Background: Curcumin and hesperetin are plant polyphenols known for their poor solubility. To address this limitation, we prepared amorphous PVP K30–phosphatidylcholine dispersions via hot-melt extrusion. Methods: This study aimed to evaluate the effects
Kamil Wdowiak, Lidia Tajber, Andrzej Miklaszewski, Judyta Cielecka-Piontek   +3 more
doaj   +1 more source

A Quaternary Solid Dispersion System for Improving the Solubility of Olaparib

Solids
To improve the low solubility of poorly water soluble olaparib, in the following study, we prepared olaparib-loaded quaternary solid dispersions with hypromellose, Tween 20 or Labrasol, and colloidal silica.
Tae-Han Yun, Jeong-Gyun Lee, Kyu-Ho Bang, Jung-Hyun Cho, Kyeong-Soo Kim   +4 more
doaj   +1 more source

Improving the biopharmaceutical performance of azole antifungals: a comparative study of solid dispersion and co-crystallization of ketoconazole and itraconazole

Journal of Applied Pharmaceutical Research
Background: Oral bioavailability of BCS class II azole antifungals, ketoconazole and itraconazole, is hampered by low aqueous solubility. Improving solubility and dissolution is necessary for greater therapeutic efficacy.
Payal Dasgupta, Bipul Nath, Apurba Talukdar, Atanu Sarma, Sidhartha Jyoti Bora   +4 more
doaj   +1 more source

Assessing the Impact of Mesoporous, Co-Amorphous, and Polymer-Based Systems on Cefdinir’s Dissolution and Stability Via Predictive Modeling

British Journal of Biomedical Science
The poor solubility and permeability of Biopharmaceutics Classification System (BCS) Class IV drugs pose major challenges to achieving sufficient oral bioavailability and therapeutic efficacy.
Raghad Al Nuss, Mohamad Anas Al Tahan, Hind El-Zein   +2 more
doaj   +1 more source