Results 1 to 10 of about 2,406 (250)

Co-Amorphous Solid Dispersions for Solubility and Absorption Improvement of Drugs: Composition, Preparation, Characterization and Formulations for Oral Delivery

Pharmaceutics, 2018
The amorphous solid state offers an improved apparent solubility and dissolution rate. However, due to thermodynamic instability and recrystallization tendencies during processing, storage and dissolution, their potential application is limited. For this
Anna Karagianni, Kyriakos Kachrimanis, Ioannis Nikolakakis   +2 more
doaj   +4 more sources

Amorphous Solid Dispersions: Implication of Method of Preparation and Physicochemical Properties of API and Excipients

Pharmaceutics
The present study investigated the effect of different polymers and manufacturing methods (hot melt extrusion, HME, and spray drying, SD) on the solid state, stability and pharmaceutical performance of amorphous solid dispersions.
Varun Kushwah, Cecilia Succhielli, Isha Saraf, Amrit Paudel   +3 more
doaj   +4 more sources

Cellulose based polymers in development of amorphous solid dispersions

Asian Journal of Pharmaceutical Sciences, 2019
Cellulose derivatives have gained immense popularity as stabilizers for amorphous solid dispersion owing to their diverse physicochemical properties. More than 20 amorphous solid dispersion-based products that have been approved for marketing consist of ...
Rahul B Chavan, Sneha Rathi, Vaskuri G S Sainaga Jyothi, Nalini R Shastri   +3 more
doaj   +4 more sources

Thermal Stability of Amorphous Solid Dispersions [PDF]

Molecules, 2021
Amorphous solid dispersion drug delivery systems (ASD DDS) were proved to be efficient for the enhancement of solubility and bioavailability of poorly water-soluble drugs.
Dijana Jelić
doaj   +3 more sources

Modelling phase separation in amorphous solid dispersions [PDF]

Acta Biomaterialia, 2019
Much work has been devoted to analysing thermodynamic models for solid dispersions with a view to identifying regions in the phase diagram where amorphous phase separation or drug recrystallization can occur.
McGinty, Sean, Meere, Martin, Pontrelli, Giuseppe   +2 more
core   +6 more sources

Amorphous Solid Dispersions: Role of the Polymer and Its Importance in Physical Stability and In Vitro Performance

Pharmaceutics, 2022
Amorphous solid dispersions stabilized by one or more polymer(s) have been widely used for delivering amorphous drugs with poor water solubilities, and they have gained great market success.
Qin Shi, Haibiao Chen, Yanan Wang, Ruoxun Wang, Jia Xu, Chen Zhang   +5 more
doaj   +2 more sources

Hot melt extrusion aided amorphous solid dispersions of quercetin and resveratrol for solubility enhancement

Journal of Applied Pharmaceutical Research
Background: Conversion of poorly soluble drugs into amorphous solid dispersions using different carriers is a formulation approach to improve solubility.
Lakshmi Swapna Sai, Fatima S Dasankoppa, Srinivas Mutalik, Muralidhar Pisay   +3 more
doaj   +3 more sources

Drug-excipient behavior in polymeric amorphous solid dispersions [PDF]

Journal of Excipients and Food Chemicals, 2016
Amorphous drug delivery systems are increasingly utilized to enhance aqueous solubility and oral bioavailability. However, they lack physical and/or chemical stability.
Surikutchi Bhanu Teja, Shashank Pralhad Patil, Ganesh Shete, Sarsvatkumar Patel, Arvind Kumar Bansal   +4 more
doaj   +1 more source

Myricetin Amorphous Solid Dispersions—Antineurodegenerative Potential

Molecules
Our research aimed to develop an amorphous solid dispersion (ASD) of myricetin (MYR) with Polyvinylpyrrolidone K30 (PVP30) to enhance its solubility, dissolution rate, antioxidant, and neuroprotective properties.
Natalia Rosiak, Ewa Tykarska, Judyta Cielecka-Piontek   +2 more
doaj   +3 more sources

Delivery of poorly soluble compounds by amorphous solid dispersions

Current Pharmaceutical Design, 2014
Solid state manipulation by amorphous solid dispersion has been the subject of intensive research for decades due to their excellent potential for dissolution and bioavailability enhancement. The present review aims to highlight the latest advancement in
Chow, S. F., Lee, Thomas W.Y., Hui, H. W., Wan, K. Y., Chow, Albert H.L., Boersen, Nathan A.   +5 more
core   +5 more sources