Results 1 to 10 of about 7,381 (260)

Myricetin Amorphous Solid Dispersions—Antineurodegenerative Potential [PDF]

Molecules
Our research aimed to develop an amorphous solid dispersion (ASD) of myricetin (MYR) with Polyvinylpyrrolidone K30 (PVP30) to enhance its solubility, dissolution rate, antioxidant, and neuroprotective properties.
Natalia Rosiak, Ewa Tykarska, Judyta Cielecka-Piontek   +2 more
doaj   +4 more sources

Amorphous Solid Dispersions: Implication of Method of Preparation and Physicochemical Properties of API and Excipients [PDF]

Pharmaceutics
The present study investigated the effect of different polymers and manufacturing methods (hot melt extrusion, HME, and spray drying, SD) on the solid state, stability and pharmaceutical performance of amorphous solid dispersions.
Varun Kushwah, Cecilia Succhielli, Isha Saraf, Amrit Paudel   +3 more
doaj   +4 more sources

Co-Amorphous Solid Dispersions for Solubility and Absorption Improvement of Drugs: Composition, Preparation, Characterization and Formulations for Oral Delivery

Pharmaceutics, 2018
The amorphous solid state offers an improved apparent solubility and dissolution rate. However, due to thermodynamic instability and recrystallization tendencies during processing, storage and dissolution, their potential application is limited. For this
Anna Karagianni, Kyriakos Kachrimanis, Ioannis Nikolakakis   +2 more
doaj   +3 more sources

The influence of the ultrasonic treatment of working fluids on electrospun amorphous solid dispersions

Frontiers in Molecular Biosciences, 2023
Based on a working fluid consisting of a poorly water-soluble drug and a pharmaceutical polymer in an organic solvent, electrospinning has been widely exploited to create a variety of amorphous solid dispersions However, there have been very few reports ...
Haibin Wang, Yingying Lu, Haisong Yang, Deng-Guang Yu, Xuhua Lu   +4 more
doaj   +2 more sources

Comment on Hermeling et al. Nano-Dry-Melting: A Novel Technology for Manufacturing of Pharmaceutical Amorphous Solid Dispersions. Pharmaceutics 2022, 14, 2145 [PDF]

Pharmaceutics
My colleagues and I are writing in response to an article published in the October 2022 issue of Pharmaceutics titled “Nano-Dry-Melting: A Novel Technology for Manufacturing of Pharmaceutical Amorphous Solid Dispersions” [...]
Dave A. Miller, Sandra U. Kucera, Daniel Ellenberger, Daniel Davis, Robert O. Williams   +4 more
doaj   +2 more sources

The combination of hydroxypropylmethylcellulose acetate succinate and L-lysine into ternary amorphous solid dispersions of quercetin to enhance its dissolution

Carbohydrate Polymer Technologies and Applications, 2021
The purpose of this study was to enhance quercetin (Que) dissolution by preparing its ternary amorphous solid dispersions. The ternary amorphous solid dispersions were prepared by solvent evaporation method using hydroxypropylmethylcellulose acetate ...
Yiru Wang, Wenrong Qin, Qi Liang, Feng Zhou, Chengyun Yan, Yueyi Deng   +5 more
doaj   +1 more source

Solubility and Physical Stability Enhancement of Loratadine by Preparation of Co-Amorphous Solid Dispersion with Chlorpheniramine and Polyvinylpyrrolidone

Pharmaceutics, 2023
Loratadine (LRD), a non-sedating and slow-acting antihistamine, is often given in combination with short-onset chlorpheniramine maleate (CPM) to increase efficacy. However, LRD has poor water solubility resulting in low bioavailability.
Krit Suknuntha, Nattakanwadee Khumpirapang, Vimon Tantishaiyakul, Siriporn Okonogi   +3 more
doaj   +1 more source

Optimizing Solvent Selection and Processing Conditions to Generate High Bulk-Density, Co-Precipitated Amorphous Dispersions of Posaconazole

Pharmaceutics, 2021
Co-precipitation is an emerging method to generate amorphous solid dispersions (ASDs), notable for its ability to enable the production of ASDs containing pharmaceuticals with thermal instability and limited solubility.
Derek Frank, Luke Schenck, Athanas Koynov, Yongchao Su, Yongjun Li, Narayan Variankaval   +5 more
doaj   +1 more source

Amorphous Solid Dispersions Layered onto Pellets—An Alternative to Spray Drying? [PDF]

Pharmaceutics, 2023
Karl G Wagner, Wagner Karl G
exaly   +2 more sources

Amorphous Solid Dispersions: Role of the Polymer and Its Importance in Physical Stability and In Vitro Performance

Pharmaceutics, 2022
Amorphous solid dispersions stabilized by one or more polymer(s) have been widely used for delivering amorphous drugs with poor water solubilities, and they have gained great market success.
Qin Shi, Haibiao Chen, Yanan Wang, Ruoxun Wang, Jia Xu, Chen Zhang   +5 more
doaj   +1 more source