Results 11 to 20 of about 1,873,271 (247)

Amorphous Solid Dispersions: Role of the Polymer and Its Importance in Physical Stability and In Vitro Performance

Pharmaceutics, 2022
Amorphous solid dispersions stabilized by one or more polymer(s) have been widely used for delivering amorphous drugs with poor water solubilities, and they have gained great market success.
Qin Shi, Haibiao Chen, Yanan Wang, Ruoxun Wang, Jia Xu, Chen Zhang   +5 more
doaj   +4 more sources

Amorphous Solid Dispersions: Implication of Method of Preparation and Physicochemical Properties of API and Excipients [PDF]

Pharmaceutics
The present study investigated the effect of different polymers and manufacturing methods (hot melt extrusion, HME, and spray drying, SD) on the solid state, stability and pharmaceutical performance of amorphous solid dispersions.
Varun Kushwah, Cecilia Succhielli, Isha Saraf, Amrit Paudel   +3 more
doaj   +3 more sources

Co-Amorphous Solid Dispersions for Solubility and Absorption Improvement of Drugs: Composition, Preparation, Characterization and Formulations for Oral Delivery

Pharmaceutics, 2018
The amorphous solid state offers an improved apparent solubility and dissolution rate. However, due to thermodynamic instability and recrystallization tendencies during processing, storage and dissolution, their potential application is limited. For this
Anna Karagianni, Kyriakos Kachrimanis, Ioannis Nikolakakis   +2 more
doaj   +4 more sources

Comment on Hermeling et al. Nano-Dry-Melting: A Novel Technology for Manufacturing of Pharmaceutical Amorphous Solid Dispersions. Pharmaceutics 2022, 14, 2145 [PDF]

Pharmaceutics
My colleagues and I are writing in response to an article published in the October 2022 issue of Pharmaceutics titled “Nano-Dry-Melting: A Novel Technology for Manufacturing of Pharmaceutical Amorphous Solid Dispersions” [...]
Dave A. Miller, Sandra U. Kucera, Daniel Ellenberger, Daniel Davis, Robert O. Williams   +4 more
doaj   +3 more sources

Solubility and Physical Stability Enhancement of Loratadine by Preparation of Co-Amorphous Solid Dispersion with Chlorpheniramine and Polyvinylpyrrolidone

Pharmaceutics, 2023
Loratadine (LRD), a non-sedating and slow-acting antihistamine, is often given in combination with short-onset chlorpheniramine maleate (CPM) to increase efficacy. However, LRD has poor water solubility resulting in low bioavailability.
Krit Suknuntha, Nattakanwadee Khumpirapang, Vimon Tantishaiyakul, Siriporn Okonogi   +3 more
doaj   +2 more sources

Hot melt extrusion aided amorphous solid dispersions of quercetin and resveratrol for solubility enhancement [PDF]

Journal of Applied Pharmaceutical Research
Background: Conversion of poorly soluble drugs into amorphous solid dispersions using different carriers is a formulation approach to improve solubility.
Lakshmi Swapna Sai, Fatima S Dasankoppa, Srinivas Mutalik, Muralidhar Pisay   +3 more
doaj   +2 more sources

Myricetin Amorphous Solid Dispersions—Antineurodegenerative Potential [PDF]

Molecules
Our research aimed to develop an amorphous solid dispersion (ASD) of myricetin (MYR) with Polyvinylpyrrolidone K30 (PVP30) to enhance its solubility, dissolution rate, antioxidant, and neuroprotective properties.
Natalia Rosiak, Ewa Tykarska, Judyta Cielecka-Piontek   +2 more
doaj   +2 more sources

Drug-excipient behavior in polymeric amorphous solid dispersions [PDF]

Journal of Excipients and Food Chemicals, 2016
Amorphous drug delivery systems are increasingly utilized to enhance aqueous solubility and oral bioavailability. However, they lack physical and/or chemical stability.
Surikutchi Bhanu Teja, Shashank Pralhad Patil, Ganesh Shete, Sarsvatkumar Patel, Arvind Kumar Bansal   +4 more
doaj   +1 more source

The combination of hydroxypropylmethylcellulose acetate succinate and L-lysine into ternary amorphous solid dispersions of quercetin to enhance its dissolution

Carbohydrate Polymer Technologies and Applications, 2021
The purpose of this study was to enhance quercetin (Que) dissolution by preparing its ternary amorphous solid dispersions. The ternary amorphous solid dispersions were prepared by solvent evaporation method using hydroxypropylmethylcellulose acetate ...
Yiru Wang, Wenrong Qin, Qi Liang, Feng Zhou, Chengyun Yan, Yueyi Deng   +5 more
doaj   +1 more source

Advances in the development of amorphous solid dispersions: The role of polymeric carriers. [PDF]

Asian J Pharm Sci, 2023
Zhang J, Guo M, Luo M, Cai T.
europepmc   +2 more sources