Results 11 to 20 of about 33,115 (300)
Myricetin Amorphous Solid Dispersions—Antineurodegenerative Potential [PDF]
MoleculesOur research aimed to develop an amorphous solid dispersion (ASD) of myricetin (MYR) with Polyvinylpyrrolidone K30 (PVP30) to enhance its solubility, dissolution rate, antioxidant, and neuroprotective properties.
Natalia Rosiak +2 more
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Thermal Stability of Amorphous Solid Dispersions [PDF]
Molecules, 2021 Amorphous solid dispersion drug delivery systems (ASD DDS) were proved to be efficient for the enhancement of solubility and bioavailability of poorly water-soluble drugs.
Dijana Jelić
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Tailoring supersaturation from amorphous solid dispersions [PDF]
Journal of Controlled Release, 2018 The maximum achievable concentration of a drug in solution is dictated by the chemical potential of the solid form. Because an amorphous solid has a higher chemical potential than the corresponding crystal form, in the absence of phase transformations, a higher transient solubility is expected.
Na Li, Lynne S. Taylor
openaire +4 more sources
Amorphous Solid Dispersions: Implication of Method of Preparation and Physicochemical Properties of API and Excipients [PDF]
PharmaceuticsThe present study investigated the effect of different polymers and manufacturing methods (hot melt extrusion, HME, and spray drying, SD) on the solid state, stability and pharmaceutical performance of amorphous solid dispersions.
Varun Kushwah +3 more
doaj +2 more sources
Pharmaceutics, 2018 The amorphous solid state offers an improved apparent solubility and dissolution rate. However, due to thermodynamic instability and recrystallization tendencies during processing, storage and dissolution, their potential application is limited. For this
Anna Karagianni +2 more
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Frontiers in Molecular Biosciences, 2023 Based on a working fluid consisting of a poorly water-soluble drug and a pharmaceutical polymer in an organic solvent, electrospinning has been widely exploited to create a variety of amorphous solid dispersions However, there have been very few reports ...
Haibin Wang +4 more
doaj +2 more sources
Comment on Hermeling et al. Nano-Dry-Melting: A Novel Technology for Manufacturing of Pharmaceutical Amorphous Solid Dispersions. Pharmaceutics 2022, 14, 2145 [PDF]
PharmaceuticsMy colleagues and I are writing in response to an article published in the October 2022 issue of Pharmaceutics titled “Nano-Dry-Melting: A Novel Technology for Manufacturing of Pharmaceutical Amorphous Solid Dispersions” [...]
Dave A. Miller +4 more
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Investigation of Stabilized Amorphous Solid Dispersions to Improve Oral Olaparib Absorption [PDF]
PharmaceuticsIn this study, we investigated the formulation of stable solid dispersions to enhance the bioavailability of olaparib (OLA), a therapeutic agent for ovarian cancer and breast cancer characterized as a BCS class IV drug with low solubility and low ...
Taehan Yun +5 more
doaj +2 more sources
Carbohydrate Polymer Technologies and Applications, 2021 The purpose of this study was to enhance quercetin (Que) dissolution by preparing its ternary amorphous solid dispersions. The ternary amorphous solid dispersions were prepared by solvent evaporation method using hydroxypropylmethylcellulose acetate ...
Yiru Wang +5 more
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Pharmaceutics, 2023 Loratadine (LRD), a non-sedating and slow-acting antihistamine, is often given in combination with short-onset chlorpheniramine maleate (CPM) to increase efficacy. However, LRD has poor water solubility resulting in low bioavailability.
Krit Suknuntha +3 more
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