Results 11 to 20 of about 2,406 (250)

The Characterization of Cannabidiol Amorphous Solid Dispersions [PDF]

, 2019
: Generating amorphous solid dispersions (ASDs) containing active pharmaceutical ingredients has become a favorable technique of emerging prominence to improve drug solubility and overall bioavailability. Cannabidiol (CBD) has now become a major focus in

core   +2 more sources

Sweeteners Show a Plasticizing Effect on PVP K30—A Solution for the Hot-Melt Extrusion of Fixed-Dose Amorphous Curcumin-Hesperetin Solid Dispersions

Pharmaceutics
The co-administration of curcumin and hesperetin might be beneficial in terms of neuroprotective activity; therefore, in this study, we attempted to develop a fixed-dose formulation comprising these two compounds in an amorphous state.
Kamil Wdowiak, Lidia Tajber, Andrzej Miklaszewski, Judyta Cielecka-Piontek   +3 more
doaj   +3 more sources

Molecular Disorder of Bicalutamide—Amorphous Solid Dispersions Obtained by Solvent Methods [PDF]

Pharmaceutics, 2018
The effect of solvent removal techniques on phase transition, physical stability and dissolution of bicalutamide from solid dispersions containing polyvinylpyrrolidone (PVP) as a carrier was investigated.
Joanna Szafraniec, Agata Antosik, Justyna Knapik-Kowalczuk, Karolina Gawlak, Mateusz Kurek, Jakub Szlęk, Witold Jamróz, Marian Paluch, Renata Jachowicz   +8 more
doaj   +2 more sources

The combination of hydroxypropylmethylcellulose acetate succinate and L-lysine into ternary amorphous solid dispersions of quercetin to enhance its dissolution

Carbohydrate Polymer Technologies and Applications, 2021
The purpose of this study was to enhance quercetin (Que) dissolution by preparing its ternary amorphous solid dispersions. The ternary amorphous solid dispersions were prepared by solvent evaporation method using hydroxypropylmethylcellulose acetate ...
Yiru Wang, Wenrong Qin, Qi Liang, Feng Zhou, Chengyun Yan, Yueyi Deng   +5 more
doaj   +1 more source

Solubility and Physical Stability Enhancement of Loratadine by Preparation of Co-Amorphous Solid Dispersion with Chlorpheniramine and Polyvinylpyrrolidone

Pharmaceutics, 2023
Loratadine (LRD), a non-sedating and slow-acting antihistamine, is often given in combination with short-onset chlorpheniramine maleate (CPM) to increase efficacy. However, LRD has poor water solubility resulting in low bioavailability.
Krit Suknuntha, Nattakanwadee Khumpirapang, Vimon Tantishaiyakul, Siriporn Okonogi   +3 more
doaj   +1 more source

Optimizing Solvent Selection and Processing Conditions to Generate High Bulk-Density, Co-Precipitated Amorphous Dispersions of Posaconazole

Pharmaceutics, 2021
Co-precipitation is an emerging method to generate amorphous solid dispersions (ASDs), notable for its ability to enable the production of ASDs containing pharmaceuticals with thermal instability and limited solubility.
Derek Frank, Luke Schenck, Athanas Koynov, Yongchao Su, Yongjun Li, Narayan Variankaval   +5 more
doaj   +1 more source

The Stabilization of Amorphous Zopiclone in an Amorphous Solid Dispersion [PDF]

AAPS PharmSciTech, 2015
Zopiclone is a poorly soluble psychotherapeutic agent. The aim of this study was to prepare and characterize an amorphous form of zopiclone as well as the characterization and performance of a stable amorphous solid dispersion. The amorphous form was prepared by the well-known method of quench-cooling of the melt. The solid dispersion was prepared by a
Milne, Marnus, Liebenberg, Wilna, Aucamp, Marique   +2 more
openaire   +4 more sources

A Review on Solid Dispersion and Carriers Used Therein for Solubility Enhancement of Poorly Water Soluble Drugs [PDF]

Advanced Pharmaceutical Bulletin, 2020
A large number of hydrophilic and hydrophobic carriers in pharmaceutical excipients are available today which are used for formulation of solid dispersions. Depending on nature of carriers the immediate release solid dispersions and/or controlled release
Avinash Ramrao Tekade, Jyoti Narayan Yadav   +1 more
doaj   +1 more source

Solid Dispersions for Drug Delivery

, 2022
Since their first application in the improvement of solubility of orally delivered drugs, applications of solid dispersions have considerably expanded to include cancer, infections, and inflammatory conditions.

core   +2 more sources

Processing Impact on In Vitro and In Vivo Performance of Solid Dispersions—A Comparison between Hot-Melt Extrusion and Spray Drying

Pharmaceutics, 2021
Presently, a large number of drug molecules in development are BCS class II or IV compounds with poor aqueous solubility. Various novel solubilization techniques have been used to enhance drug solubility.
Yongjun Li, Amanda K. P. Mann, Dan Zhang, Zhen Yang   +3 more
doaj   +1 more source