Studies on Dissolution Enhancement of Prednisolone, a Poorly Water-Soluble Drug by Solid Dispersion Technique [PDF]
Advanced Pharmaceutical Bulletin, 2011 Introduction: Prednisolone is a class II substance according to the Biopharmaceutics Classification System. It is a poorly water soluble agent. The aim of the present study was to improve dissolution rate of a poorly water-soluble drug, prednisolone, by ...
Parvin Zakeri-Milani +5 more
doaj +4 more sources
Characterization and Pharmacokinetic Study of Aprepitant Solid Dispersions with Soluplus®
Molecules, 2015 Solid dispersions are a useful approach to improve the dissolution rate and bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs).
Jinwen Liu +7 more
doaj +3 more sources
Pharmaceutics, 2020 This review aims to provide an overview of studies that address the use, in therapeutic applications, of solid dispersions (SDs) with biological activities in vitro and/or in vivo mainly made up of polymeric matrices, as well as to evaluate the bioactive
Verônica da Silva Oliveira +6 more
doaj +3 more sources
Amorphous Solid Dispersions: Implication of Method of Preparation and Physicochemical Properties of API and Excipients [PDF]
PharmaceuticsThe present study investigated the effect of different polymers and manufacturing methods (hot melt extrusion, HME, and spray drying, SD) on the solid state, stability and pharmaceutical performance of amorphous solid dispersions.
Varun Kushwah +3 more
doaj +2 more sources
Investigation of Stabilized Amorphous Solid Dispersions to Improve Oral Olaparib Absorption [PDF]
PharmaceuticsIn this study, we investigated the formulation of stable solid dispersions to enhance the bioavailability of olaparib (OLA), a therapeutic agent for ovarian cancer and breast cancer characterized as a BCS class IV drug with low solubility and low ...
Taehan Yun +5 more
doaj +2 more sources
A Review on Solid Dispersion and Carriers Used Therein for Solubility Enhancement of Poorly Water Soluble Drugs [PDF]
Advanced Pharmaceutical Bulletin, 2020 A large number of hydrophilic and hydrophobic carriers in pharmaceutical excipients are available today which are used for formulation of solid dispersions. Depending on nature of carriers the immediate release solid dispersions and/or controlled release
Avinash Ramrao Tekade +1 more
doaj +1 more source
Carbohydrate Polymer Technologies and Applications, 2021 The purpose of this study was to enhance quercetin (Que) dissolution by preparing its ternary amorphous solid dispersions. The ternary amorphous solid dispersions were prepared by solvent evaporation method using hydroxypropylmethylcellulose acetate ...
Yiru Wang +5 more
doaj +1 more source
Development and Physicochemical Characterization of Sirolimus Solid Dispersions Prepared by Solvent Evaporation Method [PDF]
Advanced Pharmaceutical Bulletin, 2014 Purpose: The aim of the present investigation was preparation and characterization of sirolimus solid dispersions by solvent evaporation technique to improve its dissolution properties.
Shahram Emami +3 more
doaj +1 more source
Solubility improvement of progesterone from solid dispersions prepared by solvent evaporation and co-milling [PDF]
, 2020 The aim of this contribution was to evaluate the impact of processing methods and polymeric carriers on the physicochemical properties of solid dispersions of the poorly soluble drug progesterone (PG). Five polymers: hydroxypropyl methylcellulose (HPMC),
Al-Obaidi, Hisham +3 more
core +1 more source
Surface Solid Dispersion and Solid Dispersion of Meloxicam: Comparison and Product Development [PDF]
Advanced Pharmaceutical Bulletin, 2017 Purpose: A comparative study was carried out between surface solid dispersion (SSD) and solid dispersion (SD) of meloxicam (MLX) to assess the solubility and dissolution enhancement approach and thereafter develop as patient friendly orodispersible tablet.
Mayank Chaturvedi +4 more
openaire +3 more sources