Results 41 to 50 of about 26,284 (265)
Research in Pharmaceutical Sciences, 2020 Background and purpose: This study aimed at preparation of solid dispersions in order to enhance dissolution of poorly water-soluble atorvastatin using supercritical CO2 technology.
Bashar Altaani +2 more
doaj +1 more source
Development and Characterization of Solid Dispersion for Dissolution Improvement of Furosemide by Cogrinding Method [PDF]
Advanced Pharmaceutical Bulletin, 2014 Purpose: The purpose of this study was to prepare and characterize solid dispersion formulation of furosemide to enhance dissolution rate. Methods: Solid dispersions with different drug: carrier ratios were prepared by cogrinding method using ...
Mohammad Reza Siahi-Shadbad +7 more
doaj +1 more source
An investigation on the solid dispersions of chlordiazepoxide
International Journal of Biomedical Science, 2007 The aim of this study was to prepare solid dispersions of chlordiazepoxide techniques to improve its dissolution rate. To this end, three techniques namely, two solvent methods and co-grinding technique were used. Solid dispersions of chlordiazepoxide in polyvinylpyrrolidone (PVP), Eudragit E100, Mannitol and Sorbitol with two different ratios of drug ...
Ali, Nokhodchi +3 more
openaire +2 more sources
Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review
Pediatric Blood &Cancer, EarlyView.ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean +7 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Timely cancer diagnosis in children and adolescents is important to improving outcomes. We aimed to quantify time to diagnosis and assess variations by patient, demographic and system‐level factors. Procedure We conducted a population‐based study of individuals aged 0–19 years diagnosed with one of 12 cancers from 2010 to 2022 in ...
Callum Mullen +5 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Journal of Applied Pharmaceutical ResearchBackground: Conversion of poorly soluble drugs into amorphous solid dispersions using different carriers is a formulation approach to improve solubility.
Lakshmi Swapna Sai +3 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
APPLICATION OF SOLID DISPERSIONS WITH NON STEROIDAL ANTI INFLAMMATORY DRUGS IN PHARMACY
Разработка и регистрация лекарственных средств, 2019 The article provides a brief overview of the use of solid dispersions of NSAIDs with polymeric carriers. Solid dispersions are entered in various dosage forms for different purposes.
I. I. Krasnuk (Junior) +8 more
doaj
Solubility enhancement of benfotiamine, a lipid derivative of thiamine by solid dispersion technique
Journal of Pharmacy and Bioallied Sciences, 2012 The present study was aimed to increase the solubility of the poorly water soluble drug benfotiamine using hydrophilic polymers (PVP K-30 and HPMC E4). Solid dispersions were prepared by kneading method.
S M Patel, R P Patel, B G Prajapati
doaj +1 more source