Results 31 to 40 of about 1,687,750 (295)

Therapeutic Applications of Solid Dispersions for Drugs and New Molecules: In Vitro and In Vivo Activities

Pharmaceutics, 2020
This review aims to provide an overview of studies that address the use, in therapeutic applications, of solid dispersions (SDs) with biological activities in vitro and/or in vivo mainly made up of polymeric matrices, as well as to evaluate the bioactive
Verônica da Silva Oliveira, Amanda Silva de Almeida, Ingrid da Silva Albuquerque, Fernanda Ílary Costa Duarte, Bárbara Cristina Silva Holanda Queiroz, Attilio Converti, Ádley Antonini Neves de Lima   +6 more
doaj   +1 more source

Formation of Hydroxyl-Amide Solid Dispersion Involving Azithromycin and Chitosan-Alginate Biopolymer to Increase the Dissolution Rate of Azithromycin

Science and Technology Indonesia, 2023
Research to increase the solubility of active pharmaceutical ingredients is usually conducted by reducing the particle size. This research is one side that used the solid dispersion systems to increase solubility, especially on macrolide antibiotics for
Mardiyanto, Budi Untari, Ady Mara, Diko Fahri Ferdiansyah   +3 more
doaj   +3 more sources

Orally Disintegrating Tablets Containing Melt Extruded Amorphous Solid Dispersion of Tacrolimus for Dissolution Enhancement

Pharmaceutics, 2018
In order to improve the aqueous solubility and dissolution of Tacrolimus (TAC), amorphous solid dispersions of TAC were prepared by hot melt extrusion with three hydrophilic polymers, Polyvinylpyrrolidone vinyl acetate (PVP VA64), Soluplus® and ...
Poovizhi Ponnammal, Parijat Kanaujia, Yin Yani, Wai Kiong Ng, Reginald B. H. Tan   +4 more
doaj   +1 more source

The application of microwave formulation and isothermal titration calorimetry for pharmaceutical compounds [PDF]

Solid dispersions are commonly used to overcome bioavailability issues of poorly water soluble drugs. Various preparation methods along with carrier systems have been used to develop solid dispersions.
Hussain, Talib
core   +2 more sources

Improved Dissolution Rate and Intestinal Absorption of Fexofenadine Hydrochloride by the Preparation of Solid Dispersions: In Vitro and In Situ Evaluation

Pharmaceutics, 2021
The objective of this study was to enhance dissolution and permeation of a low soluble, absorbable fexofenadine hydrochloride (FFH) by preparing solid dispersions using polyethylene glycol 20,000 (PEG 20,000) and poloxamer 188 as carriers.
Basanth Babu Eedara, Dinesh Nyavanandi, Sagar Narala, Prabhakar Reddy Veerareddy, Suresh Bandari   +4 more
doaj   +1 more source

Stochiometrically governed molecular interactions in drug: Poloxamer solid dispersions [PDF]

, 2010
This study probes the molecular interactions between model drugs and poloxamers that facilitate dissolution rate improvements using solid dispersions. Ibuprofen and ketoprofen solid dispersions were prepared at different mole ratios using poloxamers 407 ...
Williams, Adrian Christopher, Rawlinson, Clare Frances, Ali, W., A.C. Williams, C.F. Rawlinson, W. Ali   +5 more
core   +1 more source

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

Stabilized amorphous solid dispersions with small molecule excipients

, 2014
Chapter 21.
Holger Grohganz, Korbinian Löbmann, Riikka Laitinen, Clare J. Strachan, Jensen, Katrine Birgitte Tarp, Strachan, Clare, Katrine Tarp Jensen, Löbmann, Korbinian, Laitinen, Riikka, Thomas Rades, Rades, Thomas, Grohganz, Holger   +11 more
core   +2 more sources

Amorphous Solid Dispersions: Implication of Method of Preparation and Physicochemical Properties of API and Excipients

Pharmaceutics
The present study investigated the effect of different polymers and manufacturing methods (hot melt extrusion, HME, and spray drying, SD) on the solid state, stability and pharmaceutical performance of amorphous solid dispersions.
Varun Kushwah, Cecilia Succhielli, Isha Saraf, Amrit Paudel   +3 more
doaj   +1 more source

PREPARATION AND EVALUATION OF PIROXICAM - PLURONIC SOLID DISPERSIONS [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 2003
With an objective of enhancing the dissolution rate of piroxicam (PXM), solid dispersions(SDs) of piroxicam were prepared using different grades of pluronic F-68 (Pl. F-68), pluronicF-98 (Pl. F-98), and pluronic F-127 (Pl.
M. El-Badry, M. Fathy
doaj   +1 more source